In vitro evaluation of antileukemic activity of 17 commonly used fruits and vegetables in Taiwan

Chiang, Lien-Chai; Cheng, Hua-Yew; Liu, Mei-Chi; Chiang, Wen Chin; Lin, Chun‐Ching

doi:10.1016/j.lwt.2003.12.003

Cited by 26 publications

(16 citation statements)

References 21 publications

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“…The main treatment for the afflicted individuals is chemotherapy, but different kinds of treatments such as antibiotics, blood transfusion, radiation therapy and bone marrow transplantation, are also used for treating the disease. Although such treatments have prolonged the survival rate for the leukaemia patients, their adverse effects are difficult to cope with 16 , making the search for to safe and efficient drugs a necessity. For many years, a great deal of attention has been paid to natural compounds for treatment and prevention of human diseases 17 .…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Karami¹,

Majd²,

Mehrabian³

et al. 2012

ScienceAsia

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The present study evaluated the antimutagenic and anticancer activities of A. marina leaf extract. The antimutagenic activity of ethanol and water extracts of A. marina leaf (concentration 10 mg/plate for 48 h) was evaluated using the Salmonella typhimurium TA100 strain in the Ames test with (+S9) and without (−S9) metabolic activation, and its anticancer effect with concentrations of 200, 400, 450, 500, 600, and 800 µg/ml of ethanol extract for 24, 48, and 72 h on human leukaemic cell line HL-60 was assessed by MTT assay. The ethanol and water extracts of A. marina were revealed to have antimutagenic activity in the Salmonella mutation assay. The number of mutant colonies decreased in the presence of ethanol and water extract with (+S9) and without (−S9) metabolic activation. The ethanol extract showed a higher antimutagenic effect than the water extract, with an inhibition rate of 71% on the mutated bacterium. The MTT cell viability test showed an induction of cytotoxicity in HL-60 cells treated with the extract with IC50 values of 600, 400, and 280 µg/ml after 24, 48, and 72 h, respectively, in a concentration and time-dependent manner. Flow cytometric analysis confirmed the induction of apoptosis in the cells. Collectively, these results suggest that the Avicennia marina leaf extract contains bioactive compounds with antimutagenic and antileukaemic effects.

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Section: Introductionmentioning

confidence: 99%

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Karami¹,

Majd²,

Mehrabian³

et al. 2012

ScienceAsia

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“…Em seu país de origem, a casca do mangostão é utilizada como corante caseiro (Almeyda & Martin, 1976;Müller et al, 1995). Ji et al (2007) citam que a casca do fruto contém elevados teores de xantonas, uma classe de combinações de polifenóis; sendo o pericarpo, segundo Naczk & Shahidi (2006), uma das maiores fontes de xantonas encontradas até então, sendo verificada atividade antioxidante (Leong & Shui, 2002;Moongkarndi et al, 2004;Okonogi, et al, 2007;Leontowicz et al, 2007), ação antibacteriana (Chanarat et al, 1997), antifúngica, anti-inflamatória, antitumoral (Ho et al, 2002), e atividade antileucêmica (Matsumoto et al, 2003;Chiang et al, 2004). Possui também atividade vasorrelaxante e previne danos oxidativos causados pelo LDL, diminuindo os riscos da aterosclerose.…”

Section: Introductionunclassified

Características físicas e físico-química da casca de mangostão em três períodos da safra

Chisté¹,

Faria²,

Mattietto

2009

Rev. Bras. Frutic.

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RESUMO -Avaliaram-se as características físicas do fruto e físico-químicas da casca do mangostão colhido em diferentes períodos da safra (início, meio e fim). As características físicas dos frutos variam significativamente (p≤0,05) do início ao fim da safra, e observou-se que a média de peso dos frutos variou de 91,33 a 50,82 gramas, e a casca representa, em média, de 61,39 a 76,86% do peso total do fruto. A caracterização físico-química mostrou que a casca possui elevado teor de umidade (64,5 a 66%), fibras totais (24,9 a 29,1%), alta atividade de água (0,96 -0,98), baixo valor energético (24,8 a 34,7 Kcal/100 g) e expressivo teor de antocianinas totais (25,9 a 63,9 mg/100 g), principalmente no período intermediário da safra. Termos para indexação: Clusiaceae, composição, antocianinas, Garcinia mangostana L. PHYSICAL AND PHYSIOCHEMICAL CHARACTERISTICS OF MANGOSTEEN PEEL IN THREE HARVEST PERIODSABSTRACT -In this work, it was evaluated the physical characteristics of fruit and physiochemical of the mangosteen peel, harvested in different periods (beginning, middle and end). The physical characteristics of fruits range significantly (p≤0.05) from the beginning to the end, and it was observed that the fruits average weight, ranged from 91.33 to 50.82 g and the peel consists of an average from 72.12 to 76.86% of the total fruit weight. The physiochemical characterization shows that the peel possesses high moisture content (64.5 to 66%), total fibers (24.9 to 29.1%), high water activity (0.96 -0.98), low energy value (24.8 to 34.7 Kcal/ 100g) and expressive content of total anthocyanins (25.9 to 63.9 mg/100g), mainly in the intermediate harvest period.

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“…On the anti-proliferative level, the lychee seed has a weak antileukemic effect on both K562 and U937 cells with IC50 s close to 500 mg/mL and a selectivity index of 6 and 5, respectively when compared with the normal lung cell line HEL99. In the same study, mangosteen (G. mangostana) rind showed a stronger anti-proliferative effect and a much higher selectivity index [160]. The stimulatory effects of a proanthocyanidin-containing litchi pericarp (cf.…”

Section: Litchi Chinensismentioning

confidence: 77%

Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

Pierson

Dietzgen

Shaw

et al. 2011

Molecular Nutrition Food Res

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The plant kingdom harbours many diverse bioactive molecules of pharmacological relevance. Temperate fruits and vegetables have been highly studied in this regard, but there have been fewer studies of fruits and vegetables from the tropics. As global consumers demand and are prepared to pay for new appealing and exotic foods, tropical fruits are now being more intensively investigated. Polyphenols and major classes of compounds like flavonoids or carotenoids are ubiquitously present in these fruits, as they are in the temperate ones, but particular classes of compounds are unique to tropical fruits and other plant parts. Bioactivity studies of compounds specific to tropical fruit plants may lead to new drug discoveries, while the synergistic action of the wide range of diverse compounds contained in plant extracts underlies nutritional and health properties of tropical fruits and vegetables. The evidence for in vitro and animal bioactivities is a strong indicator of the pharmacological promise shown in tropical fruit plant biodiversity. In this review, we will discuss both the occurrence of potential bioactive compounds isolated and identified from a selection of tropical fruit plants of importance in Australia, as well as recent studies of bioactivity associated with such fruits and other fruit plant parts.

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In vitro evaluation of antileukemic activity of 17 commonly used fruits and vegetables in Taiwan

Cited by 26 publications

References 21 publications

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Características físicas e físico-química da casca de mangostão em três períodos da safra

Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

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