In vitro Evaluation of Aqueous Solution of Ephedra major on Protoscloces of Hydatid Cysts

Roshan, A.; Nayebzadeh, Hamed; Zibaei, M.; Shokrani, Hamidreza; Tarahi, M J

doi:10.18869/acadpub.aums.5.4.236

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“…[25][26][27][28][29] A survey which focused solely on the protoscolicidal activity of E. major leaves aquatic extracts demonstrated that the scolicidal effect against protoscoleces was not suggested and more research is also necessary to investigate by other extracts. 30 Finally, the present study demonstrated that the methanolic extracts of E. major might be a natural source and be used as new scolicidal agents during hydatid cysts surgery (PAIR) to reduce the risk of protoscoleces spillage. However, more researches will be needed to evaluate the in vivo effects of these extracts in a clinical setting on animals and humans.…”

Section: Discussionmentioning

confidence: 65%

In Vitro Assessment of the Protoscolicidal Activities of the Ephedra major Methanol Extracts

Zibaei¹,

Sepideh²,

Zohreh³

et al. 2017

Int J Enteric Pathog

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Background: The basic approaches for the treatment of human hydatidosis are surgery and chemotherapy. The risk of spillage of protoscoleces cannot be underestimated during surgery. Objectives: This study aimed to evaluate the scolicidal activity of Ephedra major methanol extracts against protoscoleces of hydatid cysts. Materials and Methods: Various concentrations of the methanolic extracts (0.01%-0.001%, mg/mL) of different parts of E. major were used for exposure times of 10, 20, 30, and 60 minutes. Results: Different extracts of E. major were tested, 0.1% concentration had strong scolicidal activity in 60 minutes. The stem extracts of 0.1% had very strong scolicidal effects in 60 minutes of exposure time and the mortality rate decreased with the lower concentration. Conclusion: Findings showed that scolicidal effects of E. major root extracts against cystic echinococcosis protoscoleces were less effective, while the stem and leaf extracts demonstrated more activities, respectively.

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