In vitro evaluation of chitosan‐coated liposome containing both coenzyme Q10 and alpha‐lipoic acid: Cytotoxicity, antioxidant activity, and antimicrobial activity

Zhao, Guodong; Hu, Caibiao; Xue, Ying

doi:10.1111/jocd.12369

Cited by 36 publications

(17 citation statements)

References 25 publications

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“…Coenzyme Q 10 has been identified as having potent antioxidant activity [61,62,63]. As evaluated by 2,2-diphenyl-1-picrylhydrazyl, coenzyme Q 10 exerted strong free radical scavenging activity [64].…”

Section: Mechanistic Studiesmentioning

confidence: 99%

Effect of Coenzyme Q10 Supplementation on Testosterone

Banihani

2018

Biomolecules

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Enhancing testosterone production in males is a continuous research direction for many scientists in the field, due to its role as a principal sex hormone and as a crucial modulator of well-being and general health in humans. Since 1978, there have been more than 30 studies that have connected coenzyme Q10 and testosterone. Such a link is attributable to the vigorous biological role of coenzyme Q10 as a crucial member in the energy production route in humans and animals, which is thought to have a positive influence on testosterone production, and hence on infertility, particularly male infertility. However, this connection has not yet been deliberated. The present work systematically reviews and summarizes the influence of coenzyme Q10 supplementation on testosterone. To accomplish this purpose, the Scopus, PubMed, and Web of Science databases were searched using the keywords “coenzyme Q10” versus “testosterone” for English language papers from November 1978 through October 2018. Relevant articles were also discussed and included to address an integral discussion. In summary, to date the studies conducted on human males reveal insignificant effects of coenzyme Q10 supplementation on testosterone. Similarly, rather than the reproductive toxicity studies, the studies conducted on animals did not show any positive influence of coenzyme Q10 on testosterone. However, coenzyme Q10 supplementation was found to ameliorate the reduction in testosterone induced by chemical reproductive toxicants, mainly by neutralizing the damaging effect of the generated free radicals. However, collectively these findings require further confirmation by additional research studies.

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Section: Mechanistic Studiesmentioning

confidence: 99%

Effect of Coenzyme Q10 Supplementation on Testosterone

Banihani

2018

Biomolecules

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“…In a recent work, a chitosan-coated liposome was proposed for the controlled release of coenzyme Q10 and alpha-lipoic acid, using the Cell Counting Kit-8 (CCK8) colorimetric assay to evaluate the antioxidant activity and cytotoxicity of the formulations. The results revealed that chitosan-liposome system has low cytotoxicity with an excellent antioxidant activity (clearing reactive oxygen species (ROS) from H 2 O 2 ) [55].…”

Section: Chitin and Chitosans: Structure Properties And Applicatmentioning

confidence: 99%

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

et al. 2019

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Huge amounts of chitin and chitosans can be found in the biosphere as important constituents of the exoskeleton of many organisms and as waste by worldwide seafood companies. Presently, politicians, environmentalists, and industrialists encourage the use of these marine polysaccharides as a renewable source developed by alternative eco-friendly processes, especially in the production of regular cosmetics. The aim of this review is to outline the physicochemical and biological properties and the different bioextraction methods of chitin and chitosan sources, focusing on enzymatic deproteinization, bacteria fermentation, and enzymatic deacetylation methods. Thanks to their biodegradability, non-toxicity, biocompatibility, and bioactivity, the applications of these marine polymers are widely used in the contemporary manufacturing of biomedical and pharmaceutical products. In the end, advanced cosmetics based on chitin and chitosans are presented, analyzing different therapeutic aspects regarding skin, hair, nail, and oral care. The innovative formulations described can be considered excellent candidates for the prevention and treatment of several diseases associated with different body anatomical sectors.

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“…For example, conventional sunscreens (lotions, creams) cannot penetrate into the deeper layers of the skin and remain on them for a very short time after topical application. Sunscreens in liposomal carriers can prevent skin irritation and enhance photoprotection by increasing the photostability of the active ingredient [239]. In [240], chitosomes based on the commercial lipid Phosal ® 53 MCT, nonionic surfactant Tween 80, and low-molecular weight CS, containing the UV sunscreen octyl methox-ycinnamate (EE% of over 94%), were obtained.…”

Section: Chitosomesmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

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In vitro evaluation of chitosan‐coated liposome containing both coenzyme Q10 and alpha‐lipoic acid: Cytotoxicity, antioxidant activity, and antimicrobial activity

Abstract: CCAL could be a potential antioxidant delivery system for cosmetics or pharmaceuticals without cytotoxicity and artificial preservatives free.

Cited by 36 publications

References 25 publications

Effect of Coenzyme Q10 Supplementation on Testosterone

Effect of Coenzyme Q10 Supplementation on Testosterone

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

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