In vitro evaluation of combined hyperthermia and photodynamic effects using magnetoliposomes loaded with cucurbituril zinc phthalocyanine complex on melanoma

Bolfarini, Gisele C.; Siqueira-Moura, Marigilson P.; Demets, Grégoire Jean-François; Morais, P.C.; Tedesco, Antônio Cláudio

doi:10.1016/j.jphotobiol.2012.05.009

Cited by 92 publications

(42 citation statements)

References 20 publications

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“…This result shows that the application of light and AC magnetic field together can be much more effective than the each of the two treatments applied separately (Bolfarini et al, 2012).…”

Section: Hyperthermia Treatmentmentioning

confidence: 78%

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak¹,

Yavuztürk²,

Sezer³

2012

Recent Advances in Novel Drug Carrier Systems

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“…This result shows that the application of light and AC magnetic field together can be much more effective than the each of the two treatments applied separately (Bolfarini et al, 2012).…”

Section: Hyperthermia Treatmentmentioning

confidence: 78%

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak¹,

Yavuztürk²,

Sezer³

2012

Recent Advances in Novel Drug Carrier Systems

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“…Such systems can be used as biomimetic models for studies of interaction with various hydrophobic drugs and membrane proteins, with potential applications in the field of immunology (vaccines and drugs targeting specific cell membranes). Liposomes associated with proteins can be used to study the activity of photosensitive dyes applied during photodynamic therapy (Bolfarini et al 2012;Longo et al 2012;Rocha et al 2012;Bicalho et al 2013;Faria et al 2015), as well for studies related to the ability of proteins to prevent, treat and/or act as nanosensors for various diseases (Daghastanli et al 2004;Santos et al 2006;Zucolotto et al 2007;Migliaccio et al 2008;Colhone et al 2009Colhone et al , 2015Calderon et al 2009a, b;Perinoto et al 2010;Paulovich et al 2011;Barbosa et al 2011;Salay et al 2011;Barros et al 2013;Fotoran et al 2015).…”

Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

Liposomal systems as carriers for bioactive compounds

et al. 2015

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Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a very interesting area of research. The versatility and amazing biocompatibility of liposomes has resulted in their wide-spread use in many scientific fields, and many of their applications, especially in medicine, have yielded breakthroughs in recent decades. Specifically, their easy preparation and various structural aspects have given rise to broadly usable methodologies to internalize different compounds, with either lipophilic or hydrophilic properties. The study of compounds with potential biotechnological application(s) is generally related to evaluation and risk assessment of the possible cytotoxic or therapeutic effects of the compound under study. In most cases, undesirable sideeffects are associated with an interaction of the liposome with the cell membrane and/or its absorption and subsequent interaction with a cellular biomolecule. Liposomal carrier systems have an unprecedented potential for delivering bioactive substances to specific molecular targets due to their biocompatibility, biodegradability and low toxicity. Liposomes are therefore considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds.

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“…In addition to encapsulation of nanosized particles into biocompatible hosting templates therapeutic molecules can be included for further delivery as well, either within the template [99][100][101][102][103][104][105][106][107][108] or decorating the outer surface of the template or, alternatively, decorating the encapsulated nanoparticles [109][110][111][112][113][114]. Indeed, vectorization of these material systems to target specific cells and tissues can be realized extrinsically using gradients of magnetic fields [10] or intrinsically by dressing the materials' surface with cell receptor-responsive moieties [84,115].…”

Section: Thermoresponsive Drug Delivery Systemsmentioning

confidence: 99%

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

Qi¹,

Morais

2014

J Nanomed Nanotechno

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The huge demand for biocompatible, robust, accurate and noninvasive technology to assess the temperature of a biological targeted site for monitoring the hyperthermia effect brings the topic of remote thermometry to a very high level of interest. There are already promising research directions to fulfil such demand in the short term and a review of the achievements in this issue is certainly worth. This report offers an overview of the research regarding the most promising nanothermometers nowadays, with emphasis on those addressed to remote operation while using optical or magnetic responses of nanosized materials as the thermometric property. More specifically the optical emission intensity, optical emission peak shift and optical emission lifetime will be covered as far as the optical-based nanothermometers are concerned. Additionally, for the magnetic-based nanothermometers the magnetization or the magnetic susceptibility are the thermometric properties covered in this review. Furthermore, the review includes the hyperthermia effect based on nanosized metallic or magnetic particles plus a couple of thermally-responsive polymeric drug delivery systems, aiming to provide an integrated view of the multipurpose platform offered by actuating-sensing nanoparticles. As far as the regulatory system is concerned the availability of noninvasive thermometry incorporating biocompatibility, robustness and accuracy will establish the grounds needed for the approval of the hyperthermia technology for therapeutic purposes, thus allowing the market of this technological option on a global scale.hyperthermia and thermoresponsive drug delivery systems for clinical use.Although nanothermometry is at its infancy considerable progress has been made recently in regard to its use for remote assessing the temperature at the site the nanomaterials are incorporated to. Nanoprobes allowing remote temperature-sensing using optical or magnetic properties are among the most promising directions nowadays. Most of the optical-based nanothermometers use the light-emitting intensity [15][16][17][18][19][20][21][22][23], light-emitting peak shift [24][25][26], or lifetime decay of a suitable optical band as the thermometric property [27][28][29][30]. As far as the clinical use is concerned the drawbacks of the actual optical-based nanothermometers rely on biocompatibility (usual semiconductor-based core nanoprobes or dye-based shell moieties are toxic), robustness (typical bleaching of organic-based shell moieties) or temperature accuracy (no better than 0.3°C nowadays), or even combination of these factors. Moreover, due to limitations imposed by living tissues on the optical penetration of light (optical therapeutic window in the 700-1100 nm wavelength range), noninvasive clinical use of optical excitation and signal pickup is a huge challenge, not yet solved, except for very special therapeutic applications, as for instance the photodynamic therapy for treatment (heating monitoring) of skin cancer and follow up [31]. Alternatively, ...

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In vitro evaluation of combined hyperthermia and photodynamic effects using magnetoliposomes loaded with cucurbituril zinc phthalocyanine complex on melanoma

Cited by 92 publications

References 20 publications

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Liposomal systems as carriers for bioactive compounds

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

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