In vitro evaluation of confinement, bioactivity, and degradation of a putty type bone substitute

Lopera, Aura María; Medrano-David, Daniela; Lema-Perez, Angela M.; Araque-Marín, Pedronel; Londoño, Martha Elena

doi:10.1016/j.mtcomm.2021.102105

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Injectable dental putties in syringes are a Beta Tri-calcium-phosphosilicate bone graft material with improved handling properties. It is made of bioactive glass and contains additives such as HPMC and glycerin, and it is absorbed upon implantation for tissue penetration [10]. Putty, T Egyptian Journal of Veterinary Sciences https://ejvs.journals.ekb.eg/ which was approved for dental applications in 2007, is a bioactive regenerative material that uses calcium phosphosilicate putty as an osteoconductive scaffold and interacts with adjacent tissues to reduce graft waste and chair-side time [10] The purpose of this study is to compare the effect of -tri-calcium phosphate Putty and granules on the healing of bone deformities in sheep.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Putty and Granule Beta-tricalcium Phosphate on Bone Cell Histomorphometry and Ki67 Expression in Sheep Tibia

Salih,

Al-Jewari

2024

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

HE TIME period for healing bone fractures in humans and animals is extremely important. This study aimed to compare the effect of tricalcium phosphate putty and granules on bone defect healing in sheep. The study included 4 male sheep. Each animal underwent tibia surgery by creating three defects in the same tibia, the first to apply the granule material, the second to control, and the third to apply the putty material, with an observation period of 2-8 weeks. Significant differences were observed in the number of osteocytes between the granule groups and the putty group compared to the control in the different period. Both forms showed an increase in the number of osteocytes. A significant decrease was recorded in the number of osteoblast cells in the putty group after 8 weeks of treatment. It was found that the speed of resorption of the putty material was faster in the putty form than in the granules, and the speed of the bone's response to healing was faster during the same period. The granule group displayed consistently moderate Ki67 expression at 2, 4, 6, and 8 weeks, and conversely, the putty group showed intense Ki67 expression at 4 weeks and 8 weeks. Both forms showed a good response to the healing of the bone defect, although. The putty form of β-TCP was better, had faster resorption after 8 weeks of treatment compared to the granular form.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effects of Putty and Granule Beta-tricalcium Phosphate on Bone Cell Histomorphometry and Ki67 Expression in Sheep Tibia

Salih,

Al-Jewari

2024

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…The development of injectables, putties, cements, pastes, gels, etc. is attractive in the field of bone regeneration because of its formability and stability, and products with improved operability using various materials are on the market [ 28 ]. However, there are few studies evaluating the clinical application of hydrogel-added xenograft materials among various materials.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Animal Study on Bone Formation Ability of Commercialized Particle-Type Bone Graft with Increased Operability by Hydrogel

et al. 2021

View full text Add to dashboard Cite

The purpose of this study was to evaluate the bone-generating ability of a new bovine-derived xenograft (S1-XB) containing hydrogel. For control purposes, we used Bio-Oss and Bone-XB bovine-derived xenografts. S1-XB was produced by mixing Bone-XB and hydrogel. Cell proliferation and differentiation studies were performed to assess cytotoxicities and cell responses. For in vivo study, 8 mm-sized cranial defects were formed in 16 rabbits, and then the bone substitutes were transplanted into defect sites in the four study groups, that is, a Bio-Oss group, a Bone-XB group, an S1-XB group, and a control (all n = 4); in the control group defects were left empty. Eight weeks after surgery, new bone formation areas were measured histomorphometrically. In the cell study, extracts of Bio-Oss, Bone-XB, and S1-XB showed good results in terms of the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and no cytotoxic reaction was evident. No significant difference was observed between mean new bone areas in the Bio-Oss (36.93 ± 4.27%), Bone-XB (35.07 ± 3.23%), and S1-XB (30.80 ± 6.41%) groups, but new bone area was significantly smaller in the control group (18.73 ± 5.59%) (p < 0.05). Bovine-derived bone graft material containing hydrogel (S1-XB) had a better cellular response and an osteogenic effect similar to Bio-Oss.

show abstract

Exploring the Zein/58S Bioactive Glass Nanocomposite for Enhanced Bone Tissue Engineering: A Comprehensive Investigation of Structural, Chemical, Biological, and Osteogenic Properties through in Vitro and in Vivo Studies

Esmaeili Ranjbar,

Mohandesnezhad,

Mirzaei-Parsa

et al. 2024

J Polym Environ

View full text Add to dashboard Cite

In vitro evaluation of confinement, bioactivity, and degradation of a putty type bone substitute

Cited by 4 publications

References 32 publications

The Effects of Putty and Granule Beta-tricalcium Phosphate on Bone Cell Histomorphometry and Ki67 Expression in Sheep Tibia

The Effects of Putty and Granule Beta-tricalcium Phosphate on Bone Cell Histomorphometry and Ki67 Expression in Sheep Tibia

Preliminary Animal Study on Bone Formation Ability of Commercialized Particle-Type Bone Graft with Increased Operability by Hydrogel

Exploring the Zein/58S Bioactive Glass Nanocomposite for Enhanced Bone Tissue Engineering: A Comprehensive Investigation of Structural, Chemical, Biological, and Osteogenic Properties through in Vitro and in Vivo Studies

Contact Info

Product

Resources

About