In-vitro evaluation of copper/copper oxide nanoparticles cytotoxicity and genotoxicity in normal and cancer lung cell lines

Fahmy, Heba M.; Ebrahim, Nashwa Moatez; Gaber, Mohamed H.

doi:10.1016/j.jtemb.2020.126481

Cited by 74 publications

(27 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Copper oxide (CuO) NPs have special characteristics like spin dynamics, high-temperature superconductivity, and electron correlation effects ( El-Trass et al, 2012 ). Copper can be found in two ionic conditions Cu 1+ and Cu 2+ hence it can be interacting with biochemical reactions both as a reducing or oxidizing agent, nevertheless, it is not favorable from the toxicity aspect since copper ions are capable to induce oxidative stress ( Valko et al, 2005 ), genotoxicity ( Adeyemi et al, 2020 ), and free radical production ( Fahmy et al, 2020 ).…”

Section: Toxicity Of Common Metallic and Metal Oxide Npsmentioning

confidence: 99%

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Attarilar

Yang

Ebrahimi

et al. 2020

Front. Bioeng. Biotechnol.

170

View full text Add to dashboard Cite

Thousands of different nanoparticles (NPs) involve in our daily life with various origins from food, cosmetics, drugs, etc. It is believed that decreasing the size of materials up to nanometer levels can facilitate their unfavorable absorption since they can pass the natural barriers of live tissues and organs even, they can go across the relatively impermeable membranes. The interaction of these NPs with the biological environment disturbs the natural functions of cells and its components and cause health issues. In the lack of the detailed and comprehensive standard protocols about the toxicity of NPs materials, their control, and effects, this review study focuses on the current research literature about the related factors in toxicity of NPs such as size, concentration, etc. with an emphasis on metal and metal oxide nanoparticles. The goal of the study is to highlight their potential hazard and the advancement of green non-cytotoxic nanomaterials with safe threshold dose levels to resolve the toxicity issues. This study supports the NPs design along with minimizing the adverse effects of nanoparticles especially those used in biological treatments.

show abstract

Section: Toxicity Of Common Metallic and Metal Oxide Npsmentioning

confidence: 99%

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Attarilar

Yang

Ebrahimi

et al. 2020

Front. Bioeng. Biotechnol.

170

View full text Add to dashboard Cite

show abstract

“…CuNPs have been associated with cytotoxicity mediated through oxidative stress-dependent pathways. Recently, Fahmy et al (2020) have reported that Cu/CuO NPs suppressed proliferation and viability of normal and carcinoma lung cells. Treatment of both cell types with Cu/CuO NPs resulted in the generation of a state of oxidative stress ( Fahmy et al, 2020 ).…”

Section: Antimicrobial Nanopackagingmentioning

confidence: 99%

“…Recently, Fahmy et al (2020) have reported that Cu/CuO NPs suppressed proliferation and viability of normal and carcinoma lung cells. Treatment of both cell types with Cu/CuO NPs resulted in the generation of a state of oxidative stress ( Fahmy et al, 2020 ). In another study, the toxic potentials of CuONPs were evaluated in the two types of human cell lines (HepG2 hepatocarcinoma and Caco-2 colorectal adenocarcinoma).…”

Section: Antimicrobial Nanopackagingmentioning

confidence: 99%

Antimicrobial Properties of Food Nanopackaging: A New Focus on Foodborne Pathogens

2021

View full text Add to dashboard Cite

Food products contaminated by foodborne pathogens (bacteria, parasites, and viruses) cause foodborne diseases. Today, great efforts are being allocated to the development of novel and effective agents against food pathogenic microorganisms. These efforts even might have a possible future effect in coronavirus disease 2019 (COVID-19) pandemic. Nanotechnology introduces a novel food packaging technology that creates and uses nanomaterials with novel physiochemical and antimicrobial properties. It could utilize preservatives and antimicrobials to extend the food shelf life within the package. Utilizing the antimicrobial nanomaterials into food packaging compounds typically involves incorporation of antimicrobial inorganic nanoparticles such as metals [Silver (Ag), Copper (Cu), Gold (Au)], and metal oxides [Titanium dioxide (TiO2), Silicon oxide (SiO2), Zinc oxide (ZnO)]. Alternatively, intelligent food packaging has been explored for recognition of spoilage and pathogenic microorganisms. This review paper focused on antimicrobial aspects of nanopackaging and presented an overview of antibacterial properties of inorganic nanoparticles. This article also provides information on food safety during COVID-19 pandemic.

show abstract

“…Thus, 20 mg 0.50WTi was used to study the influence of pH on RB5 photodegradation. pH Zeta potential test helped to determine the surface charge of 0.50WTi photocatalyst dispersed in solutions with different pH readings (Fahmy et al 2020). As shown in Fig.…”

Section: Photocatalyst Loadingmentioning

confidence: 99%

Photodegradation assessment of RB5 dye by utilizing WO3/TiO2 nanocomposite: a cytotoxicity study

Chau

Lee

Pang

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Textile dyeing wastewater becomes one of the root causes of environmental pollution. Titanium dioxide (TiO 2 ) is one of the photocatalysts that shows prominent organic dye photodegradation ability. In this study, a porous tungsten oxide (WO 3 )/ TiO 2 composite was prepared through ultrasonic-assisted solvothermal technique with varying amounts of WO 3 ranging from 0.25 to 5 weight % (wt.%). The prepared 0.50 wt.% WO 3 /TiO 2 (0.50WTi) composite exhibited the highest photodegradation activity (4.39 × 10 −2 min −1 ) and complete mineralization in chemical oxygen demand (COD) reading towards 30 mg.L −1 of Reactive Black 5 (RB5) dye under 60 min of light irradiation. Effects of large surface area, small crystallite size, high pore volume and size, and low electron-hole pair recombination rate attributed to the superiority of 0.50WTi. Besides, 0.50WTi could be reused, showing 86.50% of RB5 photodegradation at the fifth cycle. Scavenger study demonstrated that photogenerated hole (h + ) was the main active species of 0.50WTi to initiate the RB5 photodegradation. Cytotoxicity assessment determined the readings of half-maximal inhibitory concentration (IC 50 ) were 1 mg.mL −1 and 0.61 mg.mL −1 (24 and 72 h of incubations) for the 0.50WTi composite.

show abstract

In-vitro evaluation of copper/copper oxide nanoparticles cytotoxicity and genotoxicity in normal and cancer lung cell lines

Cited by 74 publications

References 49 publications

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Antimicrobial Properties of Food Nanopackaging: A New Focus on Foodborne Pathogens

Photodegradation assessment of RB5 dye by utilizing WO3/TiO2 nanocomposite: a cytotoxicity study

Contact Info

Product

Resources

About