In vitro evaluation of heparinized Cuprophan hemodialysis membranes

Hinrichs, Wouter L. J.; Hoopen, Hermina W.M. ten; Engbers, G.H.M.; Feijén, Jan

doi:10.1002/(sici)1097-4636(19970615)35:4<443::aid-jbm4>3.3.co;2-v

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Heparination can increase the permeability by about 10-40% higher than those of original PAN for small solutes. In hemodialysis applications, it is important to keep the permeability of uremic toxins stable for surface-modifying membranes [4,32].…”

Section: Blood Coagulationmentioning

confidence: 99%

Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate

2004

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Section: Blood Coagulationmentioning

confidence: 99%

Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate

2004

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“…The observed changes in membrane permeability therefore more likely result from conformational changes, as indicated by the changes in solution uptake which correspond to variations in the porosity of the membrane. The permeability of creatinine across the MISSM measured during this study is lower than that across a low-flux type hemodialysis membrane (Cuporophane ® ) [24] with a pore diameter of 2-3 nm [25]. Since no macropores were observed in the MISSM during scanning electron microscopy (as shown in Fig.…”

mentioning

confidence: 64%

Changes in the Porosity and Permeability of a Molecularly Imprinted Membrane Induced by the Adsorption of a Trace Quantity of Template

Yoshimi¹

2013

TOACJ

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It is known that the diffusive permeability of solutes within a thin layer of molecularly imprinted polymer (MIP) may be affected by specific binding of the MIP with its template molecule. This phenomenon, termed the gate effect, shows promise for the development of novel biomimetic sensors. However, the mechanism underlying this effect is still unclear; although the relationship between the specific adsorption of a template and the corresponding porosity and permeability of the polymeric film or membrane is very important, this association has not yet been examined in detail. We therefore studied this relationship using a molecularly imprinted self-supporting membrane (MISSM) possessing chiral specificity, specially developed as a tool for investigating the gate effect. Both the diffusive permeability and volume porosity of the MISSM were sensitive to the presence of the template compounds (D and L-phenylalanine) at concentrations as low as 5 µM, while, at the same time, insensitive to the enantiomer of the template. The relationship between the amount of adsorbed template and the equilibrium template concentration followed the expected Langmuir isotherm pattern, which indicates the thermodynamic homogeneity of binding sites in the MISSM. This study also demonstrated that the relative concentration of the adsorbed template in the membrane was only 3 ppm and relative site occupation was only 1% following exposure to a 5 µM concentration of the template. These results show that the gate effect may be advantageously exploited during application of MIPs in amplifiers or sensors offering high sensitivity.

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“…On the other hand, studies on membrane surface glycosylation can bring about many new features for the membrane surface, which is the central topic of this review. Early applications of surface glycosylation in membrane science mainly include the immobilization of natural polysaccharides such as heparin on the membrane surface to enhance its tissue and blood compatibility [17] . In recent years, some new trends occurred with the advantages of glycobiology and organic synthesis.…”

Section: Introductionmentioning

confidence: 99%

Surface glycosylation of polymeric membranes

Dai

Wan

2008

Sci. China Ser. B-Chem.

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Surface glycosylation of polymeric membranes has been inspired by the structure of natural biomembranes. It refers to that glycosyl groups are introduced onto the membrane surface by various strategies, which combine the separation function of the membrane with the biological function of the saccharides in one system. In this review, progress in the surface glycosylation of polymeric membranes is highlighted in two aspects, i.e. the glycosylation methods and the potential applications of the surface-glycosylated membranes.membrane, surface glycosylation, enzyme immobilization, protein recognition

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In vitro evaluation of heparinized Cuprophan hemodialysis membranes

Cited by 4 publications

References 2 publications

Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate

Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate

Changes in the Porosity and Permeability of a Molecularly Imprinted Membrane Induced by the Adsorption of a Trace Quantity of Template

Surface glycosylation of polymeric membranes

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