In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones

Aranda, Ana; Mayorga, Cristobalina; Ariza, Adriana; Doña, Inmaculada; Rosado, Ana; Blanca‐López, Natalia; Andreu, Inmaculada; Torres, Marı́a José

doi:10.1111/j.1398-9995.2010.02460.x

Cited by 146 publications

(179 citation statements)

References 25 publications

Supporting

Mentioning

165

Contrasting

Order By: Relevance

“…The basophil activation test is increasingly used with drugs such as ß-lactams [86], quinolones [57], protein pump inhibitors [87], corticosteroids [56], and ICM [16]. Data obtained in preliminary studies of patients who experienced immediate reactions to ICM have shown promising results.…”

Section: In Vitro Methodsmentioning

confidence: 90%

“…Some of these patients also react to other ICM to which they had not been previously exposed, probably because the core chemical structure common to ICM is part of the antigenic determinant and thus induces cross-reactivity. Specific IgE to ioxaglate and ioxithalamate has been determined in the sera of patients who experience immediate reactions to ICM using immunoassay techniques [14,51] and basophil activation tests, as reported for many other drugs [56][57][58].…”

Section: Immediate Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Rosado¹,

Díaz²,

Moreno³

et al. 2016

J Investig Allergol Clin Immunol

126

124

View full text Add to dashboard Cite

The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature. The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide). Hypersensitivity reactions can appear within the first hour after administration (immediate reactions) or from more than 1 hour to several days after administration (nonimmediate or delayed reactions). The risk factors for immediate reactions include poorly controlled bronchial asthma, concomitant medication (eg, angiotensin-converting enzyme inhibitors, ß-blockers, and proton-pump inhibitors), rapid administration of the ICM, mastocytosis, autoimmune diseases, and viral infections. The most common symptoms of immediate reactions are erythema and urticaria with or without angioedema, which appear in more than 70% of patients. Maculopapular rash is the most common skin feature of nonimmediate reactions (30%-90%). Skin and in vitro tests should be performed for diagnosis of both immediate and nonimmediate reactions. The ICM to be administered will therefore be chosen depending on the results of these tests, the ICM that induced the reaction (when known), the severity of the reaction, the availability of alternative ICM, and the information available on potential ICM cross-reactivity. Another type of contrast media, gadolinium derivatives, is used used for magnetic resonance imaging. Although rare, IgE-mediated reactions to gadolinium derivatives have been reported. Key words: Iodinated. Gadolinium. Contrast media. Allergy. Hypersensitivity. Anaphylaxis. Immediate reactions. Nonimmediate reactions. PrologueThe objective of these guidelines is to ensure efficient and effective clinical practice in the diagnosis and management of hypersensitivity reactions to radiologic contrast media. The guidelines were developed by a panel of allergy specialists from the Drug Allergy Committee of the Spanish Society of Allergy and Clinical Immunology (SEAIC) with extensive clinical expertise in the evaluation and management of hypersensitivity reactions and broad research experience.We performed a systematic and independent review of the literature up to November 2015 and established a consensus of expert opinion. We evaluated the applicability of the guidelines in our daily clinical practice. The guidelines were evaluated and criticized by external reviewers with expertise in the field. MethodThe panel of experts who produced this consensus document developed a research protocol outlining the background to the subject of study, the objectives of the study, and the questions and hypotheses from which search criteria were defined.The main sources used for the literature search included electronic databases and archives (MEDLINE-PubMed, Science Direct, OVID) and a database of systematic re...

show abstract

Section: In Vitro Methodsmentioning

confidence: 90%

Section: Immediate Reactionsmentioning

confidence: 99%

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Rosado¹,

Díaz²,

Moreno³

et al. 2016

J Investig Allergol Clin Immunol

126

124

View full text Add to dashboard Cite

show abstract

“…25) Similar results were also reported in some positive cases of IgE mediated quinolone allergies. 17) Therefore, it is not clear whether basophil responsiveness is maintained over a long period even in an IgE-mediated reaction, and CD203c expression-based basophil activation test should be performed at the early stages of carboplatin-related HR for more precise results. Further longitudinal follow-up study is needed to confirm the effect of sampling timing on basophil activation test.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17][18] Some researchers suggested that CD203c is more sensitive than CD63 for the diagnosis of drug allergy. 14,20) This may be due to the fact that CD63 is not only a marker of activated basophils but also of platelets and leukocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Flow cytometry-based tests for peripheral blood basophils can easily quantify these in vitro reactions, which presumably represent their in vivo activity for hymenoptera, latex, food and drug allergies. [9][10][11][12][13] The sensitivity of the basophil activation test for the diagnosis of drug allergy has been reported; the reported sensitivities for the diagnosis of allergy to β-lactams, [14][15][16] quinolones 17) and rocuronium 18) are 33-67%, 71.1% and 80%, respectively. In addition, increased CD63 expression on basophils has been reported in a patient with cisplatin allergy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Basophil CD203c as a Predictor of Carboplatin-Related Hypersensitivity Reaction in Patients with Gynecologic Cancer

Iwamoto

Abe

Tabata

et al. 2012

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The incidence of hypersensitivity reaction (HR) to carboplatin has been reported to increase after repeated use of the drug. However, a reliable ex vivo test to predict HR to carboplatin is not currently available. We evaluated the clinical usefulness of measuring basophil CD203c to predict carboplatin-related HR in this prospective case-control study conducted at Mie University Hospital between October 2009 and September 2010. Eleven patients had history of carboplatin-related HR within the past 3 years, and 19 had no history of HR after receiving more than 5 courses of carboplatin therapy. Six of these 19 patients developed carboplatin-related HR during the study period. The CD203c basophils (%) and the mean fluorescence intensity (MFI) were analyzed on a flow cytometer and compared between patients with and without HR. Changes in the CD203c expression on basophils before and after HR were also assessed in patients who developed HR during the study period. The median CD203c basophils (%) and ΔMFI after 30-min exposure to 50 µg/mL carboplatin were significantly higher in patients with HR (3.5% and ΔMFI 9.0) compared with those without (2.2% and ΔMFI 0.4) (p<0.05). In particular, these values were significantly higher in patients with grade 4 anaphylaxis (10.6% and ΔMFI 22.0). All five patients who developed grade 2-4 anaphylaxis during the study period had high CD203c basophils (%) and/or increased ΔMFI on the day before HR. The results suggest that basophil CD203c may be a promising biomarker for the prediction of severe carboplatinrelated anaphylaxis.

show abstract

Basophil activation after nonsteroidal anti‐inflammatory drugs stimulation in patients with immediate hypersensitivity reactions to these drugs

et al. 2014

View full text Add to dashboard Cite

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in allergic reactions of which two main types exist: IgE-mediated and crossintolerance. The diagnosis of crossintolerance reactions is often based on the drug provocation test. The potential value of the basophil activation test (BAT) was evaluated using different basophil markers in the diagnosis of patients with crossintolerance to NSAIDs and cutaneous symptoms. We studied 46 patients with crossintolerance to NSAIDs and 45 tolerant controls. BAT was performed with acetyl salicylic acid, paracetamol, diclofenac, dipyrone, naproxen, and ibuprofen at four different concentrations using CD193 and CD203c as basophil markers and CD63 as activation marker. We compared BAT results using CD193 1 or CD193 1 CD203c 1 for basophil selection and found a significant increase in the stimulation index when using CD193 1 CD203c 1 in both patients and controls (P 5 0.004 and P 5 0.017, respectively). Selection of living cells only produced an increase in basophil stimulation in patients for both CD193 1 and CD193 1 CD203c 1 (P < 0.001 for both), whereas in controls there was no change with CD193 1 and a decrease with CD193 1 CD203c 1 (P 5 0.001). We found that CD193 1 CD203c 1 increased the percentage of positive cases in patients and controls when compared with CD193 1 . When excluding dead cells, there was an increase of 21.7% in patients and 10% in controls. These results indicate that using CD193 1 CD203 1 , excluding dead cells, is the best approach for BAT although this test is not recommended for the diagnosis of patients with crossintolerance to NSAIDs owing to its low sensitivity and specificity. V C 2014 International Society for Advancement of Cytometry Key terms hypersensitivity; nonsteroidal anti-inflammatory drugs; idiosyncratic reactions; basophils; CD63; CD193; CD203c NONSTEROIDAL anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in immediate or acute hypersensitivity reactions, accounting for 20-25% of patients evaluated in allergy units, with two main mechanisms involved (1-3). One is mediated by drug-specific-IgE antibodies and reactions occur with one NSAID but there is tolerance to other nonchemically related drugs (4,5). These reactions are known as single NSAID induced hypersensitivity reactions and involve NSAIDs such as paracetamol (6), acetyl salicylic acid (ASA) (7), diclofenac (8), ketorolac (9), dipyrone (10,11), and cyclooxygenase-2 selective inhibitors (COX-2) (12). The other type of reaction is mediated by a pharmacological mechanism in which the inhibition of cyclooxygenase-1 enzyme (COX-1) leads to a decrease in the synthesis of prostaglandin E 2, which in turn hampers the production of sulphidoleukotrienes

show abstract

In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones

Abstract: Immediate hypersensitivity reactions to quinolones do occur, with moxifloxacin being the drug most frequently involved. The BAT is a useful method for diagnosing patients. Specific IgE was demonstrated by Sepharose-RIA and inhibition assay.

Cited by 146 publications

References 25 publications

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Evaluation of Basophil CD203c as a Predictor of Carboplatin-Related Hypersensitivity Reaction in Patients with Gynecologic Cancer

Basophil activation after nonsteroidal anti‐inflammatory drugs stimulation in patients with immediate hypersensitivity reactions to these drugs

Contact Info

Product

Resources

About