In vitro evaluation of selected medicinal plants for antimicrobial activities against antibiotic resistant clinical bacterial and fungal pathogens

Kadhim, Qasim Turqi; Abbas, Hussein Hameed

doi:10.22376/ijpbs.2017.8.3.p350-355

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies, such as that by TA et al, have assessed the antimicrobial potential of BM against clinical isolates of pathogenic strains, with the methanolic extract displaying a more potent inhibitory effect against K. pneumoniae and S. aureus. 36 Haque et al have described the inhibitory potential of BM against multidrug-resistant urinary tract infections (UTI) and respiratory tract infections (RTI). The diverse array of phytochemicals found in these extracts underscores their pharmaceutical significance.…”

Section: Antibacterial Potential Of Extractsmentioning

confidence: 99%

Antimicrobial Activity against Antibiotic-resistant Pathogens and Antioxidant Activity and LCMS/MS Phytochemical Content Analysis of Selected Medicinal Plants

Thakur,

Khushboo,

Yadav

et al. 2024

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

Medicinal plants are a major source of numerous therapeutic agents, and the emergence of pathogenic bacteria has rekindled interest in traditional medicine systems as an alternative approach to overcoming resistance. The dried plant material of four medicinal plants, namely Terminalia arjuna (bark), Terminalia bellirica (fruit), Aegle marmelos (leaves), and Bacopa monnieri (leaves), was powdered, and aqueous extracts were prepared. The antimicrobial activity of the extracts was evaluated against three clinically important strains: Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli 385. As E. coli 385 was resistant to the broadest spectrum of antibiotics tested, it was classified as (MDR multi-drug resistant). E. coli, Bacillus subtilis, Mycobacterium smegmatis (MTTC), and Vibrio alginolyticus (ATCC) were also assessed using the agar well diffusion method for zones of inhibition and minimum inhibitory/bactericidal concentration (MIC/MBC). Clinically important strains were found to be sensitive to the aqueous extract of T. bellerica (19.51 ± 0.61 mm) with MICs ranging from 0.31 to 0.62 mg/ml. The MDR strain was also sensitive to Bellirica monnieri (16.10 ± 0.31 mm) aqueous extract. To determine the potential for a wide range of applications, the antioxidant activities of the extracts were evaluated using DPPH, ABTS, and FRAP assays. The T. arjuna plant extract exhibited the highest radical scavenging activity with the lowest EC50 values for DPPH (1.15 ± 0.061 mg/ml) and ABTS (1.02 ± 0.07 mg/ml). The plant extracts were characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy, and LC-MS/MS.

show abstract

Section: Antibacterial Potential Of Extractsmentioning

confidence: 99%