In-vitro Evaluation of Talaromyces islandicus Mediated Zinc Oxide Nanoparticles for Antibacterial, Anti-inflammatory, Bio-pesticidal and Seed Growth Promoting Activities

Sangeeta, M. K.; Tejashree,; Gunagambhire, Vidyasagar M.; Bhat, Meghashyama Prabhakara; Nagaraja, Shashiraj Kariyellappa; Gunagambhire, Pooja V.; Kumar, Raju Suresh; Mahalingam, Sakkarapalayam M.

doi:10.1007/s12649-023-02386-z

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…The biosynthesis of ZnO NPs was performed according to previous studies with some modifications 50 , 57 . In this procedure, 50 mL of an aqueous solution of 0.1 M zinc acetate dihydrate (Zn (C 2 H 3 O 2 ) 2 .2H 2 O) was prepared under moderate-speed stirring at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells

Mongy,

Shalaby

2024

Sci Rep

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The growing interest in using plant extracts for the biogenic synthesis of zinc oxide nanoparticles (ZnO NPs) stems from their facile, eco-friendly, and biologically safe approach instead of chemical routes. For the first time, ZnO NPs were successfully biosynthesized using Rhus coriaria fruit aqueous extract as a reducing and capping agent. Characterization revealed that the biosynthesized ZnO NPs possessed a maximum absorbance of approximately 359 nm and closely resembled the hexagonal ZnO wurtzite crystalline structure, with an average crystalline size of 16.69 nm. The transmission electron microscope (TEM) showed the presence of spherical and hexagonal morphologies, with an average grain size of 20.51 ± 3.90 nm. Moreover, the elemental composition of the synthesized ZnO NPs was assessed via energy-dispersive X-ray spectrometry (EDX), and the presence of phytocompounds on their surface was subsequently verified through FT-IR analysis. The ζ-potential of ZnO NPs was recorded at − 19.9 ± 0.1663 mV. Regarding anti-cancer properties, ZnO NPs were found to possess potent anti-tumor effects on MCF-7 and MDA-MB-231 breast cancer cells. Their efficacy was dose-dependent, with IC50 values ranging from 35.04–44.86 μg/mL for MCF-7 and 55.54–63.71 µg/mL for MDA-MB-231 cells. Mechanistic studies in MDA-MB-231 cells revealed apoptosis induction, validated by DAPI staining, confocal microscopy, and Annexin V/PI staining, showing apoptosis by 12.59% and 81.57% at ½ IC50 and IC50 values, respectively. Additionally, ZnO NPs were observed to provoke S-phase arrest and inhibit colony-forming and metastatic potential by modulating apoptosis and metastasis-related genes. This study unravels new insights into how ZnO NPs provoke cancer cell death and inhibit metastasis, revealing new prospects in cancer nanotechnology.

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Section: Methodsmentioning

confidence: 99%

Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells

Mongy,

Shalaby

2024

Sci Rep

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“…Preliminary investigations for all probable binding affinity with the targeted enzyme and their interactions with the bioactive compounds of C. odorata predicted their theoretical biological data of ten bioactive compounds. The molecular docking study was performed against the bacterial protein dihydrofolate synthetase, PDB ID: 1AD1, 1AJ0, and fungal protein Lanosterol C14 α-Demethylase protein, PDB ID: 5V5Z with bioactive compounds of C. odorata (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The molecular docking scores and binding interactions of bioactive compounds with protein were shown (Table 2).…”

Section: Molecular Dockingmentioning

confidence: 99%

Unveiling the antibacterial and antifungal potential of biosynthesized silver nanoparticles from Chromolaena odorata leaves

Bishoyi,

Sahoo,

Samal

et al. 2024

Sci Rep

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This research investigates the biogenic synthesis of silver nanoparticles (AgNPs) using the leaf extract of Chromolaena odorata (Asteraceae) and their potential as antibacterial and antifungal agents. Characterization techniques like ultraviolet–visible, Fourier transform infrared (FTIR), Dynamic light scattering and zeta potential (DLS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy (FESEM-EDX) confirmed the formation of spherical (AgNPs). UV–vis spectroscopy reaffirms AgNP formation with a peak at 429 nm. DLS and zeta potential measurements revealed an average size of 30.77 nm and a negative surface charge (− 0.532 mV). Further, XRD analysis established the crystalline structure of the AgNPs. Moreover, the TEM descriptions indicate that the AgNPs are spherical shapes, and their sizes ranged from 9 to 22 nm with an average length of 15.27 nm. The X-ray photoelectron spectroscopy (XPS) analysis validated the formation of metallic silver and elucidated the surface state composition of AgNPs. Biologically, CO-AgNPs showed moderate antibacterial activity but excellent antifungal activity against Candida tropicalis (MCC 1559) and Trichophyton rubrum (MCC 1598). Low MIC values (0.195 and 0.390 mg/mL) respectively, suggest their potential as effective antifungal agents. This suggests potential applications in controlling fungal infections, which are often more challenging to treat than bacterial infections. Molecular docking results validated that bioactive compounds in C. odorata contribute to antifungal activity by interacting with its specific domain. Further research could pave the way for the development of novel and safe antifungal therapies based on biogenic nanoparticles.

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Biogenic Production of Silver Nanoparticles Using Neocosmospora Solani Endophytic Fungal Extract: Their In Vitro Antibacterial and Anticancer Properties

Nongthombam,

Kannaiah,

Raju

et al. 2024

J Inorg Organomet Polym

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In-vitro Evaluation of Talaromyces islandicus Mediated Zinc Oxide Nanoparticles for Antibacterial, Anti-inflammatory, Bio-pesticidal and Seed Growth Promoting Activities

Cited by 7 publications

References 43 publications

Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells

Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells

Unveiling the antibacterial and antifungal potential of biosynthesized silver nanoparticles from Chromolaena odorata leaves

Biogenic Production of Silver Nanoparticles Using Neocosmospora Solani Endophytic Fungal Extract: Their In Vitro Antibacterial and Anticancer Properties

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