In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

Täuber, Anja; Müller‐Goymann, Christel C.

doi:10.1016/j.ijpharm.2016.01.082

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The data on ciclopirox effectivity against dermatophytes agree with the results presented in our [ 36 ] and other scientists’ recent studies [ 37 , 38 ].…”

Section: Resultssupporting

confidence: 93%

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Assessment of Physical, Mechanical, Biopharmaceutical Properties of Emulgels and Bigel Containing Ciclopirox Olamine

et al. 2022

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Emulsions are thermodynamically unstable systems and it is difficult to produce biphasic formulations with large amounts of oil. The aim of our study was to prepare biphasic formulations containing 1% ciclopirox olamine and to determine the influence of the method of oil incorporation (without and with emulsifier and gelifier) on the physical (pH, particle size, rheological properties), mechanical, and biopharmaceutical properties of the formulations. It was found that the use of a poloxamer 407 gel as the hydrophase could result in a stable formulation when an oil with (EPG) or without an emulsifier (APG) or oleogel (OPG) was used as the oily phase. The results of the studies showed that the addition of an emulsifier (polysorbate 80) led to a decrease in the sol-gel temperature, a slower release of ciclopirox olamine, and a higher stability in the freeze–thaw test. However, regardless of the way the oil is incorporated, the particles are distributed in the same range and the antifungal activity against T. rubrum is the same. It is possible to create a biphasic formulation with a large amount of oil and poloxamer gel, but for greater stability, it is recommended to include an emulsifier in the composition.

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“…The data on ciclopirox effectivity against dermatophytes agree with the results presented in our [ 36 ] and other scientists’ recent studies [ 37 , 38 ].…”

Section: Resultssupporting

confidence: 93%

“…Formulations without the pharmaceutical substance showed no inhibition. The data on ciclopirox effectivity against dermatophytes agree with the results presented in our [36] and other scientists' recent studies [37,38].…”

Section: Antifungal Activity Studysupporting

confidence: 92%