In vitro evaluation of the antibacterial activity of modified multi-walled carbon nanotubes with phenolic extracts

Abstract

Conventional Antibiotics such as ciprofloxacin, ofloxacin and levofloxacin are an important group of antimicrobials which are widely used in the treatment of various infectious diseases. Long-term treatment with antibiotics can cause side effects in consumers. Bactericidal antibiotics may persuade the establishment of toxic reactive oxygen types (ROS) in bacteria. In the present study, we tried to eliminate the side effects of antibiotics by modification of multi wall carboxylated nanotubes with phenolic extractives that are extracted of pigmented vegetables. Very low concentrations of functionalized nanotubes were tested against both Gram-positive and Gram-negative bacteria. Antibacterial activity of the products was compared with MIC values of conventional antibiotics. In vitro studies represented that killed bacteria in the presence of low concentrations of modified nanotubes. so, the extremely abilities of functionalized carboxylated multiwall nanotubes have the potential to be described as innocuous antibiotic candidates.