In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents

Korinth, Gintautas; Geh, Stefan; Schaller, K. H.; Drexler, Hans

doi:10.1007/s00420-002-0429-y

Cited by 47 publications

(17 citation statements)

References 26 publications

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“…This phenomenon of skin barrier creams, known as ''penetration enhancement'', is well established by experimental data in diffusion cell studies using various industrial chemicals. [33][34][35] In the rubber industry, AA in the workplace air are primarily bound on particles. 36 The use of skin barrier creams with this type of exposure of hazardous substances at workplaces could promote the adherence of particles to the treated skin.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams

Korinth

Weiß²,

Penkert

et al. 2006

Occup Environ Med

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Background: Several aromatic amines (AA) could cause bladder cancer and are an occupational hygiene problem in the workplace. However, little is known about the percutaneous absorption of chemicals via impaired skin and about the efficacy of skin protection measures to reduce internal exposure. Aims: To determine the impact of skin status and of skin protection measures on the internal exposure to AA in workers manufacturing rubber products. Methods: 51 workers occupationally exposed to aniline and o-toluidine were examined. The workplace conditions, risk factors for skin and the use of personal protective equipment were assessed by means of a self-administered questionnaire. The skin of hands and forearms was clinically examined. Exposure to aniline and o-toluidine was assessed by ambient air and biological monitoring (analyses of urine samples and of haemoglobin adducts). Results: Haemoglobin-AA-adduct levels in workers with erythema (73%) were significantly higher (p,0.04) than in workers with healthy skin (mean values: aniline 1150.4 ng/l vs 951.7 ng/l, o-toluidine 417.9 ng/l vs 118.3 ng/l). The multiple linear regression analysis showed that wearing gloves significantly reduced the internal exposure. A frequent use of skin barrier creams leads to a higher internal exposure of AA (p,0.03). However, the use of skincare creams at the workplace was associated with a reduced internal exposure (p,0.03). From these findings we assume that internal exposure of the workers resulted primarily from the percutaneous uptake. Conclusions: The study demonstrates a significantly higher internal exposure to AA in workers with impaired skin compared with workers with healthy skin. Daily wearing of gloves efficiently reduced internal exposure. However, an increased use of skin barrier creams enhances the percutaneous uptake of AA. Skincare creams seem to support skin regeneration and lead to reduced percutaneous uptake.

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Section: Discussionmentioning

confidence: 99%

Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams

Korinth

Weiß²,

Penkert

et al. 2006

Occup Environ Med

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“…16 Their use should not be over promoted as this may confer on workers a false sense of security and encourage them to be complacent in implementing the appropriate preventative measures. Despite experimental data showing the efficacy of barrier creams, 17 their potential value is still viewed with scepticism. 18 After-work creams A well conducted trial has shown that moisturisers may increase the susceptibility to irritants, yet in practice 19 afterwork creams appear to confer some degree of protection against developing ICD.…”

Section: Barrier Creamsmentioning

confidence: 99%

Current concepts of irritant contact dermatitis

English

2004

Occup Environ Med

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“…Skin barrier creams and protective gloves were developed for topical skin protection from exposure to chemical agents [100] and for the reduction of percutaneous absorption of industrial solvents [101] .…”

Section: Penetration Reducersmentioning

confidence: 99%

Overcoming the Stratum Corneum: The Modulation of Skin Penetration

Trommer

Neubert

2006

Skin Pharmacol Physiol

465

279

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It is preferred that topically administered drugs act either dermally or transdermally. For that reason they have to penetrate into the deeper skin layers or permeate the skin. The outermost layer of the human skin, the stratum corneum, is responsible for its barrier function. Most topically administered drugs do not have the ability to penetrate the stratum corneum. In these cases modulations of the skin penetration profiles of these drugs and skin barrier manipulations are necessary. A skin penetration enhancement can be achieved either chemically, physically or by use of appropriate formulations. Numerous chemical compounds have been evaluated for penetration-enhancing activity, and different modes of action have been identified for skin penetration enhancement. In addition to chemical methods, skin penetration of drugs can be improved by physical options such as iontophoresis and phonophoresis, as well as by combinations of both chemical and physical methods or by combinations of several physical methods. There are cases where skin penetration of the drug used in the formulation is not the aim of the topical administration. Penetration reducers can be used to prevent chemicals entering the systemic circulation. This article concentrates on the progress made mainly over the last decade by use of chemical penetration enhancers. The different action modes of these substances are explained, including the basic principles of the physical skin penetration enhancement techniques and examples for their application.

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In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents

Cited by 47 publications

References 26 publications

Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams

Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams

Current concepts of irritant contact dermatitis

Overcoming the Stratum Corneum: The Modulation of Skin Penetration

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