In vitro evaluation of the cytotoxicity and modulation of mechanisms associated with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid in human colon myofibroblasts CCD-18Co

Giménez‐Bastida, Juan Antonio; Surma, Magdalena; Zieliński, Henryk

doi:10.1016/j.tiv.2015.07.001

Cited by 22 publications

(8 citation statements)

References 76 publications

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“…Although PFAS have also been recently shown to have cytotoxic potential and to induce inflammation, processes that could adversely affect kidney function, 29 the association of PFAS with chronic disease may vary in diseases characterized by chronic hypoxia, such as diabetes and kidney disease. 4 , 30 This is particularly important given the relatively high prevalence of anemia among persons with both diabetes and CKD.…”

Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes

Conway¹,

Badders²,

Costacou³

et al. 2018

DMSO

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BackgroundAnemia often complicates chronic kidney disease (CKD), leading to insufficient tissue oxygenation and hypoxic injury, the factor thought to underlie progression from CKD to renal failure. Perfluorocarbons are potent oxygen transporters used in organ preservation and synthetic blood development. Data are scarce on their relationship with kidney function, especially in diabetes where anemia and hypoxia are more prevalent. We investigated the relationship of perfluoroalkyl acids (PFAS) with kidney function and variation by diabetes and anemia status.MethodsData on 53,650 adults (5,210 with diabetes) were obtained from the C8 Health Project. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid, perfluorooctane sulfonate, and perfluorononanoic acid.FindingsEach PFAS was positively associated with eGFR among those with CKD or anemia; this was the strongest among those with both CKD and anemia, followed by those with CKD uncomplicated by anemia. These relationships were more pronounced among those with diabetes (all P<0.01). In the absence of both CKD and anemia, PFAS was inversely associated with eGFR. Among persons with both anemia and diabetes, when further stratified by CKD stage, compared to an eGFR <30, ORs (95% CI) for being in the eGFR ≥ 90, 60–89, 45–59, and 30–45 range, respectively, were 3.20 (2.00–5.13), 2.64 (1.83–3.80), 3.18 (2.17–4.67), and 1.99 (1.38–2.86) for each ng/dL increase in PFHxS. Results were similar for each PFAS.InterpretationPFAS are inversely associated with kidney function in CKD and diabetes, with a stronger relation observed when anemia is present.

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Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes

Conway¹,

Badders²,

Costacou³

et al. 2018

DMSO

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“…Myofibroblasts are key players in inflammatory response in intestine due to their capacity to coexpress and generate prostaglandin, which plays an important role in intestinal epithelial proliferation, differentiation, and inflammation by secreting growth factors and cytokines . This cell line has been used to investigate anti‐inflammatory properties of polyphenols .…”

Section: Methodsmentioning

confidence: 99%

Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS‐induced inflammation in colonic myofibroblasts

Agah

Kim

Mertens‐Talcott

et al. 2017

Molecular Nutrition Food Res

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“…Long-chain PFAS exposure (PFOA, PFDA, and PFUnA) in mice cause an allergic inflammatory response [114,115]. PFOA can also alter T cell profiles and expression of proinflammatory cytokines in the spleen of mice [116], and PFOS, PFOA and PFDA induced the release of inflammatory cytokines in cells [117,118]. In human bronchial epithelial cells, proinflammatory cytokine release resulted following exposure to PFOA and PFOS but not PFBS, PFHxS and the fluorotelomer 8:2 FTOH [119].…”

Section: Induces Chronic Inflammationmentioning

confidence: 99%

“…PFOA Association: [105]; [106]; [107]; [108]; [110]; [112] No association: [109] Association: [115]; [116] Association: [90]; [117] Long-chain PFAS a PFOS Association: [110] No association: [107]; [113] Association: [114] Association: [117]; [119] PFHxS…”

Section: Epidemiological Animal Bioassay In Vitromentioning

confidence: 99%

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

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In vitro evaluation of the cytotoxicity and modulation of mechanisms associated with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid in human colon myofibroblasts CCD-18Co

Cited by 22 publications

References 76 publications

Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes

Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes

Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS‐induced inflammation in colonic myofibroblasts

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

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