In vitro evaluation of Transdermal Patch of Palonosetron for Antiemetic Therapy

Tripathi, Atul; Tyagi, P. C.; Vyas, Amber; Gidwani, Beena; Chandekar, Amol; Sharma, Hemant

doi:10.5138/09750215.2186

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…Similarly, the porous delignified biofilm also exhibits slightly higher transparency than original wood slice (Figure b), due to the elimination of light absorption as the colored lignin was removed . Overall, the enhanced transparency makes our biofilms more cosmetically acceptable and also facilitates the observation of the skin condition such as the side effects (redness, dermatitis, etc) of feedback transdermal therapy of On‐skinE.…”

Section: Resultsmentioning

confidence: 86%

“…Besides, human skin is also the largest therapeutic interface, the transdermal therapy is now one of the most useful ways to deliver a drug systemically for treating many diseases (such as emesia, Parkinson's disease, cancer, and diabetes mellitus). As seen in Figure g, our biofilms guide the directional flow of artificial sweat to trigger the lighting of LEDs with higher brightness than the original wood slice.…”

Section: Resultsmentioning

confidence: 99%

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Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Zhou

Wang

Huang

et al. 2019

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thermoelectric [3,4] and moisture-inducedelectric [5] effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouse). However, several challenges are to be faced, "thin-film" On-skinE I) cannot install "bulky" heatsinks [6] or sweat transport channels, but the output power of the thermoelectric generator and moistureinduced-electric generator depends on the temperature difference (∆T) across generator [4] and the ambient humidity (AH), [5] respectively; II) also lack a routing and accumulation of sweat for biosensing technologies, [7,8] and lack a targeted delivery of drugs for precise feedback transdermal therapy technologies; [9,10] and III) need insulate between the heatgenerating unit and heat-sensitive unit.In these regards, a "routing and accumulation" of heat and sweat can "concurrently" enhance the ∆T/AH-dependent output power, enable a reliable sweatbased biosensing, and prove the ability of targeted delivery of saline-soluble drugs for precise feedback transdermal therapy. Therefore, it is in great demand for developing strong-guiding films, which can help insulate between units and guide the heat and sweat to another in-plane direction.Besides, breathability [3] and stretchability [11] are essential for the on-skin use of electronics with long-term comfort. Several strategies have been proposed to realize the "stretchability" and the strategy placing rigid electronic units on the Thin-film electronics are urged to be directly laminated onto human skin for reliable, sensitive biosensing together with feedback transdermal therapy, their self-power supply using the thermoelectric and moisture-induced-electric effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouses). However, "thin-film" On-skinE 1) cannot install "bulky" heatsinks or sweat transport channels, but the output power of thermoelectric generator and moisture-induced-electric generator relies on the temperature difference (∆T ) across generator and the ambient humidity (AH), respectively; 2) lack a routing and accumulation of sweat for biosensing, lack targeted delivery of drugs for precise transdermal therapy; and 3) need insulation between the heat-generating unit and heat-sensitive unit. Here, two breathable nanowood biofilms are demonstrated, which can help insulate between units and guide the heat and sweat to another in-plane direction. The transparent biofilms achieve record-high transport // /transport ⊥ (//: along cellulose nanofiber alignment direction, ⊥: perpendicular direction) of heat (925%) and sweat (338%), winning applications emphasizing on ∆T/AH-dependent output power and "reliable" biosensing. The porous biofilms are competent in applications where "sensitive" biosensing (transporting // sweat up to 11.25 mm s −1 at the 1st second), "insulating" between units, and "targeted" delivery of saline-soluble drugs are of uppermost priority.

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Zhou

Wang

Huang

et al. 2019

Small

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“…Moisture content:-The film was weighed and kept in a desiccators containing calcium chloride at 40° C in a drier for at least 24 hr or more until it showed a constant weight and was reported in terms of percentage (by weight) moisture content [9].…”

Section: Evaluation Of Transdermal Patches:-mentioning

confidence: 99%

“Formulation and Evaluation of Transdermal Patches of Prednisolone”

Chirayu.¹,

T.S²,

Vijapure³

2019

JBPR

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The purpose of this research work was to develop and evaluate transdermal patch of Prednisolone, using Xanthan gum, Guar gum and Polyacrylamide in different ratios prepared by the Glass Substrate Technique. The physicochemical compatibility of the polymers and the drug was evaluated by FTIR. The results suggested that no physicochemical incompatibility between the polymer and the drug. Drug free films were formulated and evaluated characteristics like flexibility and smoothness. Further drug loaded films were formulated and evaluated for thickness, weight uniformity, drug content, folding endurance and drug release. The XRD analysis confirmed the amorphous dispersion of the drug in the formulation. SEM analysis showed surface morphology of prepared formulations. Drug diffusion through cellophane membrane was carried out using Franz diffusion cell by in-vitro study. The film prepared with formulation PDS 9 showed maximum diffusion release at the end of 24 hours. It is shown that drug release follows order and non Fikinian mechanism of release diffusion. The PDS 9 formulation was found to be stable with respect to drug content as well as physical changes at 40 ºC and 75 % RH. Keywords: Transdermal drug delivery, Prednisolone, Xanthan gum, Guar gum, Polyacrylamide.

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In vitro evaluation of Transdermal Patch of Palonosetron for Antiemetic Therapy

Cited by 2 publications

References 12 publications

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

“Formulation and Evaluation of Transdermal Patches of Prednisolone”

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