Purpose: To compare surgical parameters among eyes undergoing laser-assisted cataract surgery (LACS) using different lens fragmentation patterns (LFP).Methods: Prospective, randomized, unmasked clinical trial. One-hundred eyes underwent LACS and were randomly assigned to 1 of 3 LFP treatment groups: 1) laser capsulotomy only; no lens fragmentation (NLF) (n = 34); 2) three-plane chop (TPC) (n = 33); and, 3) pie-cut pattern (PCP) fragmentation (n = 33). Prechop phacoemulsification (PHACO) was performed on all eyes using the same femtosecond (FS) laser and active fluidics PHACO machine. Main outcome measures: FS laser dock time (seconds), PHACO time (seconds), PHACO power (%), cumulative dissipated energy (CDE) (%-seconds), irrigating fluid volume and operative time.Results: The 3 treatment groups were comparable in terms of patient age (P = 0.164) and nuclear density (P = 0.669). FS dock time was higher in the PCP group ( 184.18 ± 25.86) compared to the TPC (145.09 ± 14.15) group (P< 0.001). PHACO time was significantly shorter in the PCP (23.19 ± 17.20 seconds) compared to TPC (35.27 ± 17.70) and NLF (46.15 ± 23.72) groups (P< 0.001). PHACO power was lower in the PCP (11.81 ± 3.71) compared to the NLF (14.41 ± 1.88) and TPC (14.04 ± 2.46) groups (P< 0.001). CDE was lower in the PCP (2.85 ± 2.32) compared to NLF (6.55 ± 3.32) and TPC (6.55 ± 5.45) groups (P<0.001). Fluid volumes and operative times were similar. Conclusion: LFP can influence PHACO surgical parameters. Extensive fragmentation patterns such as PCP appear to lower PHACO time, power and CDE and may potentially reduce the risk of PHACO related complications.