In vitro fertilization and oocyte donation in women 45 years of age and older

Yaron, Yuval; Amit, Ami; Brenner, S.; Peyser, M. Reuben; David, Menachem P.; Lessing, Joseph B.

doi:10.1016/s0015-0282(16)57299-9

Cited by 18 publications

(5 citation statements)

References 22 publications

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“…Our extensive experience suggests that this relatively low PR is unlikely to be due to incompetence. It is rather, we believe, the result of certain factors regarding patient selection: (i) the heterogeneity of the population which includes patients who may have decreased endometrial receptivity including those of advanced age (Levran et al, 1991;Meldrum, 1993;Yaron et al, 1993Yaron et al, , 1995, and patients with an abnormal karyotype (Yaron et al, 1996); (ii) the inclusion of a greater proportion of patients who have repeatedly failed previous embryo transfer cycles; and (iii) the use of anonymous donors only, undergoing IVF themselves, in accordance with the regulations of the Israeli Ministry of Health. Such donors are, in fact, 'subfertile'.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, clinical studies comparing oocyte donation in younger and older women have also indicated that there is an age-related decline in PR (Levran et al, 1991;Yaron et al, 1993Yaron et al, ,1995Meldrum, 1993;Cano et al, 1996). Since donated oocytes are obtained from young patients, the age-related decline in PR with oocyte donation cannot be attributed to oocyte quality.…”

Section: Discussionmentioning

confidence: 99%

“…Group B (functional ovaries) comprised 251 patients with retained ovarian function as manifested by menstrual periods of varying regularity, and FSH concentrations within the normal range for the reproductive period. These included 114 patients with poor response to menotrophins, 87 patients with repeated failures in standard IVF, 39 women ഛ44 years of age whose chance of pregnancy in standard IVF was considered extremely low (Yaron et al, 1995), and 11 patients with a genetic trait precluding use of their own oocytes. Patients' age ranged from 21 to 54 years.…”

Section: Ovum Recipientsmentioning

confidence: 99%

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Oocyte donation in Israel: a study of 1001 initiated treatment cycles

Yaron

Ochshorn²,

Amit³

et al. 1998

Human Reproduction

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There are numerous studies concerning pregnancy rates in oocyte donation, yet only a handful report the obstetric outcome in such pregnancies. The purpose of this study was to assess factors that influence pregnancy rates, to determine the incidence of complications, and to evaluate obstetric outcome in pregnancies resulting from oocyte donation. This study included 423 oocyte recipients who underwent 1001 oocyte donation cycles at the Oocyte Donation Programme, In-Vitro Fertilization (IVF)-Embryo Transfer Unit, Herzlia Medical Center, Israel. Donors were all healthy women < 34 years old who underwent IVF themselves. In 873 cycles, fertilization occurred and embryo transfer was performed, resulting in 194 clinical pregnancies. Pregnancy rates (PR) significantly declined with the increase in number of previous attempts, and with increasing age of recipient (36.8%/embryo transfer in patients < or = 30 compared to 17.8% in patients > 40 years old). A significant increment in PR was noted with the increasing number of embryos transferred. The overall PR was 22.2%/embryo transfer. However, in young amenorrhoeic patients with normal karyotypes undergoing their first cycle, PR was 52.2%; the 'take home baby' rate was 38.3% per patient undergoing embryo transfer and 17.8% per embryo transfer cycle. A significant increase in the incidence of pregnancy-induced hypertension and a higher proportion of abortions were noted in older patients. A significantly higher incidence of prematurity and low birthweight was observed in multiple pregnancies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ovum Recipientsmentioning

confidence: 99%

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Oocyte donation in Israel: a study of 1001 initiated treatment cycles

Yaron

Ochshorn²,

Amit³

et al. 1998

Human Reproduction

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“…On the other hand, it was reported that advanced maternal age of surrogate mothers cannot be the reason for the lower frequency of positive results in IVF when using donated eggs from third‐party donors (Check et al ., 1993; Sauer et al ., 1993; Borini et al ., 1995; Yaron et al ., 1995). The results of pregnancies in surrogate mothers of different ages were similar.…”

Section: Effect Of Parental Age On Aberration Developmentmentioning

confidence: 99%

Chromosomal anomalies in human gametes and pre-implantation embryos, and their potential effect on reproduction

Szczygiet

Kurpisz

2001

Andrologia

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This paper reviews the latest data on chromosomal abnormalities in human gametes and embryos. A close relationship between such anomalies and reproduction failure in humans has been postulated, thereby underscoring the importance of ongoing studies into the mechanisms leading to anomalies. Until recently, knowledge of chromosomal anomalies in human gametes and embryos has been limited. Newly developed strategies (in vitro fertilization combined with micromanipulation techniques followed by multicolour fluorescence in situ hybridization, and PCR analyses) allow precise investigation of this problem. This review of the available information on the etiology of chromosomal anomalies indicates that some of the genetic anomalies in human gametes and early embryos result in reproductive failure.

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“…20 Practitioners also recommend that women over age 40 trying IVF should consider using eggs from younger women to increase their chances of pregnancy, inasmuch as birth rates for women over 40 in IVF programs approximate those of younger participants when donated eggs are used. 21 ' 22 By using hormonal therapy and donated eggs, even postmenopausal women can give birth.…”

Section: Degree Of Needmentioning

confidence: 99%

Fetal Motherhood: Toward a Compulsion to Generate Lives?

Bonnicksen

1997

Camb Q Healthc Ethics

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A scientist at Edinburgh University announced in 1994 that he had removed ovaries from, mouse fetuses and transplanted them, to adult mice. The ovaries released eggs, and conceptions occurred. Although this was not the first such attempt with mice, the study attracted attention because the researcher suggested, that fetal to adult ovarian transplants were a theoretical possibility for humans. If aborted, fetuses were used, as egg sources in assisted conception, a new entity would arise: the never-born genetic mother. Using eggs from aborted fetuses for conception would lead to quixotic and novel family ties. Its use would echo surrogate gestational motherhood, in which a child has both a genetic mother who contributed her egg and a gestational mother who contributed her uterus for gestation and childbirth. With fetal egg use, however, the child's genetic mother would be a never-born fetus without sentience or known, physiology.

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In vitro fertilization and oocyte donation in women 45 years of age and older

Cited by 18 publications

References 22 publications

Oocyte donation in Israel: a study of 1001 initiated treatment cycles

Oocyte donation in Israel: a study of 1001 initiated treatment cycles

Chromosomal anomalies in human gametes and pre-implantation embryos, and their potential effect on reproduction

Fetal Motherhood: Toward a Compulsion to Generate Lives?

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