In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome

Donnelly, Eilish; Lewis, Sheena; McNally, J. A.; Thompson, W.

doi:10.1016/s0015-0282(98)00146-0

Cited by 218 publications

(156 citation statements)

References 20 publications

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“…Percentage sperm motility has been recognized as an important spermatozoal trait for male fertility in rainbow trout (Moccia & Munkittrick 1987, Ciereszko & Dabrowski 1994, Lahnsteiner et al 1998, human (Donnelly et al 1998) and poultry (Donoghue 1999). The present study indicates that 91% of the variance in sperm competition of common carp with different percentages of sired larvae in competition can be explained by differences between the sperm of the competent males (different sperm motility, different hatching, different colour, etc).…”

Section: Discussionmentioning

confidence: 55%

Spermatozoal competition in common carp (Cyprinus carpio): what is the primary determinant of competition success?

Linhart¹,

Rodina²,

Gela³

et al. 2005

Reproduction

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The percentage of sperm motility (92-100%), spermatozoan velocity (112 -163 mm·s 21 ) and control hatching rates (83-96%) were evaluated for each of six gold and five green male common carp (Cyprinus carpio). In all 30 possible paired combinations of sperm-competition tests, hatching rates of 90 -97% were achieved. The mean percentage of offspring sired was strongly influenced by the male used (P < 0.001, R 2 5 0.91). The best male sired an average of 88% of the offspring in its competition tests, and the worst male sired only 5%. Spermatozoan-quality parameters could explain only part of the variation in male competitive ability. The male effects alone explained 91.4% of the observed variance, consisting of 17.1% explained by spermatozoan motility and 32.5% by control hatching rates in single fertilizations. Undetermined male effects explained 41.8%. The velocity of spermatozoa had no effect on the outcome of sperm competition. Neither was there any link between spermatozoan velocity and hatching rate in a control hatching test, whereas there was an effect of motility on hatching rate in this same test.Reproduction ( IntroductionSperm competition occurs when the spermatozoa of several males compete for fertilization. Competition is a major force for spermatozoan selection, but its implications for mating systems and on life-history evolution are only just beginning to be understood (Parker 1998, Gage et al. 2004. Trade-offs between gamete characteristics and relative gametic investment has been modelled by evolutionary stable strategy (ESS) approaches, when the optimal strategy for a male depends on the strategy adopted by other individuals in the population , Parker 1998, Petersen & Warner 1998. All of the models assume that males obtain more fertilization success by releasing more sperm, this being done at a cost to investment in other fitness-enhancing functions such as growth, finding additional males, investment in female function, mate defence, territoriality or releasing more sperm in other spawnings. As applied to fish, sperm-competition trials with paternity analysis have been conducted in several salmonid species (Gage et al. 1995, Gile & Ferguson 1995, Liley et al. 2002 and recently also in cyprinids (Kortet et al. 2004, Reichard et al. 2004a, 2004b or other species such as bluegill sunfish (Lepomis macrochirus; Burness et al. 2004). In rainbow trout (Oncorhynchus mykiss) male potency, defined as the ability of males to sire progeny when their sperm is pooled with that of other males, was not affected by the female gametes used, and decreased significantly when sperm concentrations were equalized (Gile & Ferguson 1995). Sperm vary in morphology, behaviour (speed, trajectory, percentage of sperm motility, etc.) and longevity in fishes. Currently, the mechanism of this variation is poorly explained (Cosson et al. 1999). There appear to be intraspecific differences that may correlate with male-mating type in Atlantic salmon (Salmo salar; Gage et al. 1995). Fishes show one of the widest ranges ...

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Section: Discussionmentioning

confidence: 55%

Spermatozoal competition in common carp (Cyprinus carpio): what is the primary determinant of competition success?

Linhart¹,

Rodina²,

Gela³

et al. 2005

Reproduction

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“…This assumption is based on the significant decline in sperm motility among rats similarly exposed to BaP for duration of 10 days (Inyang et al, 2003). Sperm progressive motility is positively correlated with fertilization of oocytes (Donnelly et al, 1998) and pregnancy rates (Jouannet et al, 1988), the decline of which is one of the markers of male reproductive toxicity and also an indicator for the onset of infertility (Perreault, 1997). Post exposures, PAHs undergo an AHH-mediated transformation into reactive metabolites (Ou and Ramos, 1992;Nebert et al, 2000) which subsequently induce ROS production.…”

Section: Discussionmentioning

confidence: 99%

Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene

Ramesh

Inyang

Lunstra

et al. 2008

Experimental and Toxicologic Pathology

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The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 rats to inhaled benzo(a)pyrene (BaP). Rats were assigned randomly to a treatment or control group. Treatment consisted of sub-chronic exposure of rats via inhalation to 75μg BaP/ m 3 , 4 hours daily for 60 days, while control animals were unexposed (UNC). Blood samples were collected immediately after the cessation of exposures (time 0) and subsequently at 24, 48, and 72 hrs, to assess the effect of bioavailable BaP on plasma testosterone and luteinizing hormone (LH) concentrations. Rats were sacrificed after the last blood collection. Testes were harvested, weighed and prepared for histology and morphometric analysis, and cauda epididymides were isolated for the determination of progressive motility and density of stored spermatozoa. BaP exposure reduced testis weight compared with UNC (Mean ± SE; 2.01 ± 0.11 vs. 3.04 ± 0.16 g; P< 0.025), and caused significant reductions in the components of the steroidogenic and spermatogenic compartments of the testis. Progressive motility and mean density of stored spermatozoa were reduced (P< 0.05). Plasma testosterone concentrations were decreased by two-thirds in BaPexposed rats throughout the time periods studied compared with those of their UNC counterparts (P< 0.05), concomitant with increased concentrations of LH in BaP-exposed rats (P< 0.05). These data suggest that sub-chronic exposure to inhaled BaP contribute to reduced testicular and epididymal function in exposed rats.

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“…On the other hand, the results of CS (56.1%) and PM (55.6%) here obtained indicated that the spermatzoa can be conserved during one day only, this is due to that citric acid and sugar compounds provide a source of energy enough for the sperm metabolism and to increase motility [37] but can decrease viability. Previous studies indicate that the use of Triladyl can provide substrates such as citric acid, which through a series of chemical reactions favor sperm motility due to an increase of ATP production [38].…”

Section: Discusionmentioning

confidence: 66%

Motility and Functional State of the Membrane of Caprine Capacitated Spermatozoa under Different Chemical Agents

Martı́nez¹,

Herrera-Camacho²,

Correa³

2012

OJVM

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The objective of this study was to test the use of a commercial extender (Triladyl) as a diluent in caprine semen refrigerated at 15˚C, using caffeine (CF), heparin (HP), synthetic oviductal fluid (SOF) andtriladyl (TRY) as capacitating chemical agents at different times. Twenty ejaculates of caprine semen were collected using an artificial vagina. The ejaculates were diluted and refrigerated by three days. Evaluated the progressive motility (PM) and the functional state of the sperm plasma membrane trough fluorescent CTC staining, counting 200 spermatic cells (non-capacitated spermatozoa NCS, capacitated CS and reacting spermatozoa REA) of caprine in two capacitating agents: CAF and HEP; one culture medium: SOF and a commercial extender: TRY at 60, 120, 180 and 240 min of incubation, during 24, 48 and 72 hs. PM was high under TRY, and CS was high under the HEP treatment. TRY could be an alternative to capacitate caprine spermatozoa, keeping PM for a longer time than HEP or CAF.

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In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome

Cited by 218 publications

References 20 publications

Spermatozoal competition in common carp (Cyprinus carpio): what is the primary determinant of competition success?

Spermatozoal competition in common carp (Cyprinus carpio): what is the primary determinant of competition success?

Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene

Motility and Functional State of the Membrane of Caprine Capacitated Spermatozoa under Different Chemical Agents

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