In Vitro Fertilization and Risk for Hypertensive Disorders of Pregnancy: Associations With Treatment Parameters

Luke, Barbara; Brown, Morton B.; Callan, Caitriona; Botting, Beverley; Pacey, Allan; Sutcliffe, Alastair; Baker, Valerie L.

doi:10.1097/ogx.0000000000000852

Cited by 13 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same paper, further analysis also demonstrated that programmed FET pregnancies were associated with higher incidences of preeclampsia than natural FET pregnancies, which had a comparable risk as fresh IVF pregnancies (50). This nding was again supported by Luke and colleagues (52). These studies proposed that performing FET during a natural cycle or with supplementation of missing hormones, such as relaxin, may potentially reduce the risk of preeclampsia and HDP.…”

Section: Comparison With Existing Literaturementioning

confidence: 77%

“…The observed difference between fresh ET and FET may be explained by the absence of a corpus luteum (CL), as suggested by ve recently published cohort studies (32,(49)(50)(51)(52). SC typically develop under the presence of one CL, while the number of CL for IVF pregnancies varies depending on the type of procedure.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

“…SC typically develop under the presence of one CL, while the number of CL for IVF pregnancies varies depending on the type of procedure. Fresh IVF cycles typically involve more than one CL, whereas frozen IVF cycles and OD are usually performed under programmed cycles with exogenous hormones in the absence of a CL (49,52).…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

See 2 more Smart Citations

Assisted Reproductive Technology and Hypertensive Disorders of Pregnancy: Systematic Review and Meta-Analyses

Chih

Elias

Gaudet

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundHypertensive disorders of pregnancy (HDP) is one of the most common pregnancy complications and causes of maternal morbidity and mortality. Many cohort studies were conducted to study adverse pregnancy outcomes associated with pregnancies from assisted reproductive technology. We aimed to comprehensively review all available evidence to date to compare the odds of HDP and preeclampsia between pregnancies achieved by in vitro fertilization (IVF) and spontaneous pregnancies.MethodsWe conducted a systematic review and meta-analysis based on cohort studies identified from EMBASE, MEDLINE, and Cochrane Library (up to 2020) and manually using a structured search strategy. Cohort studies that compared pregnancies after IVF with or without intracytoplasmic sperm fertilization (ICSI) and SC with HDP or preeclampsia as the outcome of interest were included. The control group was women who conceived spontaneously without ART or fertility medications. Studies published in English, French, Chinese, and Portuguese were reviewed. Eligibility and quality of studies were evaluated by two reviewers independently. Quality assessment was conducted using the Newcastle Ottawa Scale (NOS) for Cohort Studies. The pooled results were reported in odds ratios (OR) with 95% confidence intervals based on random effects models. I-squared (I2) test was used to evaluate heterogeneity and publication bias was assessed using funnel plots.ResultsSeventy-eight studies were included after a screening of 1,879 abstracts and 275 full text articles. Compared to SC, IVF/ICSI singleton pregnancies (OR 1.63; 95% CI 1.54-1.74; I2 = 79%) and multiple pregnancies (OR 1.31; 95% CI 1.18-1.47; I2 = 73%) were both associated with higher odds of HDP. Singleton pregnancies with oocyte donation had the highest odds of HDP out of all groups analyzed (OR 4.11; 95% CI 2.75-6.16; I2 = 85%). Frozen embryo transfer resulted in higher odds of HDP (OR 1.74; 95% CI 1.58-1.92; I2 = 55%) than fresh embryo transfer (OR 1.43; 95% CI 1.33-1.53; I2 = 72%). Similar findings for preeclampsia were also reported.ConclusionsOur meta-analysis confirmed that IVF/ICSI pregnancies are at high odds of HDP and preeclampsia than SC, irrespective of the plurality. The odds were especially high in frozen embryo transfer and oocyte donation pregnancies.

show abstract

Section: Comparison With Existing Literaturementioning

confidence: 77%

Section: Comparison With Existing Literaturementioning

confidence: 99%

Section: Comparison With Existing Literaturementioning

confidence: 99%

See 1 more Smart Citation

Assisted Reproductive Technology and Hypertensive Disorders of Pregnancy: Systematic Review and Meta-Analyses

Chih

Elias

Gaudet

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The mean fetal weights did not differ in this study, but the percentage of LGA infants was significantly higher in the programmed cycles compared with modified natural cycles (13.5% vs. 12.3%; P ¼ .008). These studies (75,76) taken together suggest the corpus luteum plays a role in aberrant fetal growth and hypertensive disorders of pregnancy.…”

Section: Possible Association Between Frozen Et Lga and Hypertensive Disorders Of Pregnancymentioning

confidence: 96%

Large for gestational age after frozen embryo transfer: an evaluation of the possible causes for this relationship

et al. 2021

View full text Add to dashboard Cite

Frozen embryo transfer is associated with increased fetal weight, increased rates of large for gestational age (LGA) infants, and increased macrosomia, when compared with fresh embryo transfer or natural conception. Although the incidence of LGA births after frozen embryo transfer has been stable for several years, the pathological causes for these findings are not understood. The purpose of this review is to understand the state of current literature suggesting causes for this relationship, and to highlight areas in need of future research to potentially address and correct this finding. Our review addresses finding in the area with respect to alterations in epigenetics, differing types of embryo culture media, differing days of cryopreservation, supraphysiologic estradiol levels, and with programmed versus natural cycle endometrial preparation. (Fertil Steril Rev Ò 2021;2:21-31. Ó2020 by American Society for Reproductive Medicine.

show abstract

“…Women at risk are those with prepregnancy overweight or obesity, pregestational diabetes, and hypertension [30,31]. In addition, advanced maternal age, use of assisted reproductive technology, especially after frozen embryo transfer [32], and multiple pregnancy are relevant further risk factors for the occurrence of eclampsia [31].…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy

et al. 2021

View full text Add to dashboard Cite

Neuroactive steroids such as dehydroepiandrosterone (DHEA), estradiol (E2), and progesterone (P4) are associated with structural and functional changes in the central nervous system (CNS). Measurement of steroid levels in the CNS compartments is restricted in accessibility. Consequently, there is only limited human data on the distributional equilibrium for steroid levels between peripheral and central compartments. While some neuroactive steroids including DHEA and E2 have been reported to convey excitatory and proconvulsant properties, the opposite was demonstrated for P4. We aimed to elucidate the correlation between peripheral and central DHEA, E2, and P4 levels in women at term pregnancy. CSF and serum samples of 27 healthy pregnant women (22–39 years) at term pregnancy were collected simultaneously under combined spinal and epidural anesthesia and used for DHEA ELISA and E2, and P4 ECLIA. All three neuroactive steroids were detected at markedly lower levels in CSF compared to their corresponding serum concentrations (decrease, mean ± SD, 97.66 ± 0.83%). We found a strong correlation for DHEA between its serum and the corresponding CSF levels (r = 0.65, p = 0.003). Serum and CSF levels of E2 (r = 0.31, p = 0.12) appeared not to correlate in the investigated cohort. DHEA serum concentration correlated significantly with E2 (r = 0.58, p = 0.0016) in CSF. In addition, a strong correlation was found between DHEA and E2, both measured in CSF (r = 0.65, p = 0.0002). Peripheral DHEA levels might serve as an indicator for central nervous levels of the neuroactive steroids DHEA and E2 in pregnant women.

show abstract

In Vitro Fertilization and Risk for Hypertensive Disorders of Pregnancy: Associations With Treatment Parameters

Cited by 13 publications

References 0 publications

Assisted Reproductive Technology and Hypertensive Disorders of Pregnancy: Systematic Review and Meta-Analyses

Assisted Reproductive Technology and Hypertensive Disorders of Pregnancy: Systematic Review and Meta-Analyses

Large for gestational age after frozen embryo transfer: an evaluation of the possible causes for this relationship

Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy

Contact Info

Product

Resources

About