In-vitro fertilization: influence of women's age on pregnancy rates

Piette, C; Mouzon, J. de; Bachelot, A; Spira, Alfred

doi:10.1093/oxfordjournals.humrep.a137041

Cited by 165 publications

(55 citation statements)

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“…Using multivariable regression approaches, we explored associations between trace elements and IVF outcomes, adjusted for confounders selected a priori based on the literature, including age (years), BMI (kg/m 2 ), race (Bother^/ BAsian^), and current or past cigarette smoking (Bnever^/ Bever^) [25][26][27][28]. Trace element data were natural logtransformed after adding a constant to accommodate negative values and zeros, as were continuous study outcomes to satisfy distributional assumptions and to stabilize variances.…”

Section: Discussionmentioning

confidence: 99%

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

Ingle

Bloom

Parsons

et al. 2016

J Assist Reprod Genet

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Purpose A hypothesis-generating pilot study exploring associations between essential trace elements measured in follicular fluid (FF) and urine and in vitro fertilization (IVF) endpoints. Methods We recruited 58 women undergoing IVF between 2007 and 2008, and measured cobalt, chromium, copper, manganese, molybdenum, and zinc in FF (n = 46) and urine (n = 45) by inductively coupled plasma mass spectrometry (ICP-MS). We used multivariable regression models to assess the impact of FF and urine trace elements on IVF outcomes, adjusted for age, body mass index, race, and cigarette smoking.Results Trace elements were mostly present at lower concentrations in FF than in urine. The average number of oocytes retrieved was positively associated with higher urine cobalt, chromium, copper, and molybdenum concentrations. FF chromium and manganese were negatively associated with the proportion of mature oocytes, yet urine manganese had a positive association. FF zinc was inversely associated with average oocyte fertilization. Urine trace elements were significant positive predictors for the total number of embryos generated. FF copper predicted lower embryo fragmentation while urine copper was associated with higher embryo cell number and urine manganese with higher embryo fragmentation. No associations were detected for implantation, pregnancy, or live birth. Conclusions Our results suggest the importance of trace elements in both FF and urine for intermediate, although not necessarily clinical, IVF endpoints. The results differed using FF or urine biomarkers of exposure, which may have implications for the design of clinical and epidemiologic investigations. These initial findings will form the basis of a more definitive future study.

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Section: Discussionmentioning

confidence: 99%

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

Ingle

Bloom

Parsons

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…This can not be compared directly with our age effect results, because of the difference in treatment, especially the ovarian hyperstimulation. For example, it is possible that controlled ovarian hyperstimulation delays the appearance of this age effect, Two studies on stan dard IVF found a gradual decrease in positive preg nancy test results or ultrasound evidence of a gesta tional sac and live birth rates after the age of 34 years (9) and a steeper decline in the pregnancy rate after the age of 37 years than before the age of 37 years (7).…”

Section: Discussionmentioning

confidence: 99%

The impact of the woman's age on the success of standard and donor in vitro fertilization

Stolwijk¹,

Zielhuis²,

Sauer³

et al. 1997

Fertility and Sterility

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Objective:To study the effect of the age of the woman who provides the oocytes 01 who receives the embryos on results of IVF-ET.Design: Historical cohort study. Multi vai'iate regression analysis was used to study the ago effect continuously and after adjustment for confounding. Result(s):The number of oocytes decreased with aging of the oocyte provider. More women who received oocytes from donors aged 20 to 23 years had at least one good embryo transferred than women who received oocytes from older donors. The age of the woman who received the embryos had no effect on IVF outcomes. In women > 40 years who underwent standard IVF, the probability of pregnancy decreased. No such relationships were observed for donor IVF, but all the oocyte donors were younger.Conclusion(s): An age effect for ongoing pregnancy was only found in women > 40 years who underwent standard IVF independent of the lower number of oocytes and suggests decreas ing oocyte quality. (Fertil Steril® 1997; 67:702" 10

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“…Therefore, the success rates of intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) are not associated with male age. [33][34][35][36] On the other hand, the success rate of intrauterine insemination (IUI), which is a method requiring much higher sperm quality and capability, is without question related to male age. 26,37 GENETIC RISKS OF AGING MALES Women should no longer be viewed as solely responsible for age-related fertility and genetic problems.…”

Section: Fertility Of Aging Menmentioning

confidence: 99%

The male biological clock is ticking: a review of the literature

2008

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The term biological clock is usually used by physicians and psychologists to refer to the declining fertility, increasing risk of fetal birth defects and alterations to hormone levels experienced by women as they age. Female fecundity declines slowly after the age of 30 years and more rapidly after 40 and is considered the main limiting factor in treating infertility. However, there are several scientific reports, chapters in books and review articles suggesting that men may also have a biological clock. The aim of our study was to conduct a review of the literature, based on the Medical Literature Analysis and Retrieval System Online (Medline), to evaluate the male biological clock. After adjustments for other factors, the data demonstrate that the likelihood that a fertile couple will take more than 12 months to conceive nearly doubles from 8% when the man is < 25 years old to 15% when he is > 35 years old. Thus, paternal age is a further factor to be taken into account when deciding on the prognosis for infertile couples. Also, increasing male age is associated with a significant decline in fertility (five times longer to achieve pregnancy at the age of 45 years). Patients and their physicians therefore need to understand the effects of the male biological clock on sexual and reproductive health, in that it leads to erectile dysfunction and male infertility, as well as its potential implications for important medical conditions such as diabetes and cardiovascular diseases.

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In-vitro fertilization: influence of women's age on pregnancy rates

Cited by 165 publications

References 0 publications

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

The impact of the woman's age on the success of standard and donor in vitro fertilization

The male biological clock is ticking: a review of the literature

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