In vitro fertilization is a successful treatment in endometriosis-associated infertility

Opøien, Hans Kristian; Fedorcsák, Péter; Omland, Anne Katerine; Åbyholm, Thomas; Bjercke, Sverre; Ertzeid, Gudvor; Oldereid, Nan Birgitte; Mellembakken, Jan Roar; Tanbo, Tom

doi:10.1016/j.fertnstert.2012.01.112

Cited by 142 publications

(114 citation statements)

References 54 publications

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“…Our results are in concordance with the 2011 registry data from the SART; both live birth rates per cycle commenced and implantation rates are comparable to tubal factor controls. Similar to our results, in 2,245 women with various stages of endometriosis or tubal factor infertility undergoing IVF, comparable pregnancy rates were recently reported among early-stage, late-stage disease and control groups [10]. In contrast to our results, the 2002 meta-analysis, after adjusting for stimulation regimen, publication date and female age, reported significantly less implantation and pregnancy rates in the endometriosis group compared to the controls; furthermore, the late-stage disease was associated with significantly lower pregnancy rates [7].…”

Section: Discussionsupporting

confidence: 92%

“…The results of these meta-analyses, however, are in contrast to the 2011 registry data from Society for Assisted Reproductive Technology (SART); both live birth rates per cycle commenced and implantation rates are comparable to tubal factor controls [9]. A recent study enrolling 1,074 patients with different stages of endometriosis and 1,171 patients with tubal factor controls also concluded that endometriosis per se was not associated with inferior pregnancy rates [10]. …”

Section: Introductionmentioning

confidence: 99%

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Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Polat¹,

Boynukalın²,

Yaralı³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To analyze whether the presence of endometriosis per se is associated with inferior pregnancy rates in women undergoing in vitro fertilization (IVF). Methods: Between July 2005 and November 2012, a total of 485 patients with endometriosis under the age of 38 years undergoing their first IVF attempt at our center were included; 72 patients had minimal-mild disease and the remaining 413 patients had moderate-severe disease. 131 patients with laparoscopically confirmed tubal factor infertility not harboring endometriosis and hydrosalpinx under the age of 38 years undergoing their first IVF attempt at our center served as the control group. Results: The bilateral antral follicle count and controlled ovarian hyperstimulation response were diminished in the moderate-severe group. However, the implantation, clinical pregnancy, miscarriage and live birth rates were comparable among the three groups. The recurrence of endometrioma following pre-IVF cystectomy was not associated with inferior pregnancy rates. Female age, bilateral antral follicle count and number of embryos transferred were noted to be significant independent predictors of live birth. Conclusion: We conclude that neither the presence nor the extent of endometriosis have any detrimental effect on IVF pregnancy rates.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Polat¹,

Boynukalın²,

Yaralı³

et al. 2014

Gynecol Obstet Invest

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“…In a preliminary study [36] Mathieu d'Argent et al, found a PR after one IVF-ICSI cycle of 41%. Moreover, in accordance with a previous study [35], no difference in PR was noted between women with colorectal endometriosis and those with tubal or male infertility. Subsequently, in a multicenter study including the women from Mathieu d'Argent et al's series, Ballester et al [37] showed that the cumulative PRs after one and two IVF-ICSI cycles were 29.3 and 52.9%, respectively.…”

Section: Fertility After Mar In Women With In Situ Colorectal Endometsupporting

confidence: 92%

“…This first-intention MAR option would appear to be suitable as a previous study [35] demonstrated that, with the exception of women with endometrioma, infertile women with various stages of endometriosis have the same PR rates in IVF-ICSI than those with tubal factor. In a preliminary study [36] Mathieu d'Argent et al, found a PR after one IVF-ICSI cycle of 41%.…”

Section: Fertility After Mar In Women With In Situ Colorectal Endometmentioning

confidence: 95%

Colorectal endometriosis and fertility

Daraı̈

Cohen

Ballester

2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: The goal of this review was to assess the impact of colorectal endometriosis on spontaneous fertility and the potential benefit of Medically Assisted Reproduction (MAR) (in vitro fertilization and intrauterine insemination) and surgery on fertility outcomes.Study design: MEDLINE search for articles on fertility in women with DIE published between 1990 and December 2015 using the following terms: "deep endometriosis", "deep infiltrating endometriosis", "bowel endometriosis", "colorectal endometriosis", "fertility", "infertility", "IVF-ICSI", "Assisted Reproductive Techniques (ART)", and "MAR".Results: Spontaneous pregnancy rate (PR) in patients undergoing resection of DIE but leaving in situ colorectal endometriosis was 26.5% (95% CI = 14-39). PR after MAR was 27.4% (95% CI = 19-35) and the overall PR was 37.9% (95% CI = 29-37). After colorectal surgery, among the 855 patients with and without proved infertility, the spontaneous PR was 31.4% (95% CI = 28-34) without difference between the groups. PR after MAR was 19.8% (95% CI = 17-22). PR after MAR in patients with and without proved infertility was 21.4% (95% CI = 18-25) and 15.5% (95% CI = 11-20), respectively. The overall PR after colorectal surgery was 51.1% (95% CI = 48-54). Conclusion:Our review supports a potential benefit of surgery on fertility outcomes for women with colorectal endometriosis. Further studies are required to determine whether surgical management should be first-intention or restricted to failure of MAR.

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“…Some authors suggest that IVF performance (oocytes quality, fertilization rates, embryo quality, and live birth rates) in the presence of endometriosis is impaired [18,34] while others show reserved outcomes [35,48]. Nevertheless, when good quality oocytes are fertilized, or when a large number of embryos is available, implantation rates seem to return to control values [49].…”

Section: Embryo/egg Freezingmentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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In vitro fertilization is a successful treatment in endometriosis-associated infertility

Cited by 142 publications

References 54 publications

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Colorectal endometriosis and fertility

The role of fertility preservation in patients with endometriosis

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