In vitro fertilization outcome in women with unoperated bilateral endometriomas

Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis

“…Pooling of results from three studies Benaglia et al, 2013;Yanushpolsky et al, 1998) that reported the duration of stimulation ( Figure 2B) did not show a difference between the two groups (WMD 0.22 days; 95% CI: −0.14 to 0.57). The I 2 value was 0%, indicating that heterogeneity was unlikely between the studies.…”

“…Total gonadotrophin consumption Pooling of results from three studies Benaglia et al, 2013;Bongioanni et al, 2011) that reported total dose of gonadotrophin (Figure 2A) did not show a difference between ovarian endometrioma group and control group (weighted mean difference [WMD 108.56 IU; 95% CI −207.06 to 424.17). Significant heterogeneity existed among the studies, as indicated by an I 2 value of 83% (P = 0.003).…”

“…Pooling of results from six studies Ashrafi et al, 2014;Benaglia et al, 2013;Bongioanni et al, 2011;Reinblatt et al, 2011;Yanushpolsky et al, 1998) that reported total number of oocytes retrieved ( Figure 3A) found 1.50 fewer oocytes retrieved in those with ovarian endometrioma than in those without ovarian endometrioma (WMD −1.50; 95% CI −2.84 to −0.15, P = 0.03). Significant variation existed across studies as indicated by an I 2 value of 91% (P < 0.00001).…”

“…Some studies have shown that ovarian endometrioma could adversely affect the number of oocytes retrieved (Suzuki et al, 2005;Yanushpolsky et al, 1998), oocyte quality, embryo quality and implantation rate (Azem et al, 1999;Yanushpolsky et al, 1998). Studies, however, found no adverse effect of ovarian endometrioma on oocyte quality, embryo quality, implantation rate and pregnancy rate (Ashrafi et al, 2014;Benaglia et al, 2013). Previous meta-analyses have shown inconsistent results and were focused on different stages of endometriosis or pregnancy outcome (Barnhart et al, 2002;Harb et al, 2013).…”

Endometrioma and Infertility: Principles and Techniques of Management

“…A systematic review from 2009 comparing surgical with no treatment of endometrioma in women undergoing IVF did not reveal a signifi cant effect on pregnancy rates [ 32 ]. However, a more recent study showed that the presence of endometrioma affected the numbers of oocytes retrieved, although oocyte quality and clinical pregnancy rate were not found to differ from women without endometrioma [ 33 ]. The long protocol with GnRH down-regulation has been shown to be favourable in women with moderate to severe endometriosis by increasing clinical pregnancy rate [ 34 ].…”