In vitro Fluoride Uptake in Human Dental Enamel from Various Fluoride Solutions

In enamel fluoride uptake studies, the most frequently sampled site is the middle third of the buccal surface. Because different parts of the enamel surface vary in fluoride concentration, the present study investigated fluoride uptake at contrasting sites using two different topical agents. One was a neutral aqueous solution of sodium fluoride containing 2% w/w of fluoride, and the second was an aqueous solution of two amine fluorides containing 1% w/w of fluoride. The enamel of 10 pairs of clinically sound extracted human premolars was etched initially and after treatment with one of these agents on the cervical and middle thirds of the buccal surface and on the proximal surface, yielding the pre- and post-treatment fluoride concentrations of these sites at depths of 5 and 10 μm from the surface. Enamel treated with the amine F solution had significantly higher fluoride uptakes at all sites compared to the NaF-treated specimens. The differences in uptake from the two agents varied with site, being smallest for the buccal middle third enamel and greatest for the proximal enamel. It is suggested that these results relate to possibje differences in enamel maturation or to the presence of initial proximal caries, and the greater affinity of amine fluoride for porous enamel. The findings emphasise the importance of obtaining site-specific data in the study of fluoride in enamel.

Section: Pre-treatment Fluoride Concentrationssupporting

confidence: 88%

Section: Pre-treatment Fluoride Concentrationsmentioning

confidence: 99%

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Enamel Fluoride Uptake Affected by Site of Application: Comparing Sodium and Amine Fluorides

Mok¹,

Hill²,

Newman

1990

“…It may well be that concentrations lower than 0.4% may be equally effective. In vitro studies on sound human enamel have recently shown that there was no statistically signif icant difference between the amount of fluoride ingested after the application of APF gels that varied in fluoride concentra tion between 0.1 and 1.23% [Dijkman et al, 1982], Kirkegaard[ 1977] compared the fluoride uptake in sound human enamel after the application of NaF, APF, MFP, SnF2, Na2SnF6 and amine fluoride, BaijotStroobants and Vreven [1979] compared APF, MFP and amine fluoride. Both groups of workers found that the highest enamel fluoride levels were found after the application of amine fluoride solutions.…”

mentioning

confidence: 99%

Lower Fluoride Concentrations for Topical Application

Sluiter¹,

Purdell-Lewis²

1984

The potential toxicity of fluoride application can be reduced by using lower fluoride concentrations. A previous study has shown that 0.4% F^–– and 1.2% F^–– organic fluoride gels were equally effective in preventing demineralization in both sound and primed human enamel. In this study 0.4, 0.1 and 0.01 % F^–– amine fluoride and acidulated phosphate fluoride (APF) solutions were tested to see whether a further reduction in concentration was possible. All amine fluoride groups and 0.4% F^–– APF showed significantly shallower lesions than controls. Lesion depth in both amine fluoride and APF groups increased with decreasing F^–– concentration. APF groups showed a tendency for deeper lesions than amine fluoride groups. All fluoride groups showed significantly higher minimum vol% mineral in the subsurface lesion than the controls; these values decreased with decreasing F^–– concentration. It can be concluded that under these experimental conditions adequate protection against further acid attack was provided by 0.4% F^–– amine fluoride followed by 0.4% F^–– APF.

“…Comparative studies of fluoride uptake at the enamel surface from various fluoridecontaining gels and solutions have been pre viously reported [Muhlemann et al, 1967;Arends and Schuthof, 1975;Kirkegaard, 1977],…”

mentioning

confidence: 99%

Determination by Charged Particles Activation of Fluoride Uptake in Human Dental Enamel

Baijotstroobants¹,

Vreven²

1979

Fluoride concentrations in the surface enamel of extracted incisors of adults were determined by prompt activation by proton bombardment. The teeth were then submitted to 4 min of topical fluoride treatments (commercial gels and solutions), and fluoride enrichments were measured after a short rinsing. The non-destructivity of the technique allowed to use the same area of the tooth before and after treatment. The highest amounts of fluoride were deposited in enamel treated with an amine fluoride solution (10,545 ppm). Good results were obtained with APF gels (2,200 ppm), whereas MFP gel gave a very low enrichment (243 ppm). Kinetic studies allowed to follow the rate of fluoride fixation which appears to vary according to a logarithmic scale.