Background: An in vitro study was performed to assess the effect of three implant abutment angulations and three core thicknesses on the fracture resistance of overlaying computer-aided manufacturing (CAM) milled zirconia (Cercon Ò system) single crowns. Methods: Three groups, coded A to C, with different implant abutment angulations (group A ⁄ 0°, group B ⁄ 15°and group C ⁄ 30°angulation) were used to construct 15 crowns for each angulation. Forty-five overlay restorations were milled using the Cercon Ò system with zirconium core thicknesses of 0.4, 0.6 and 0.8 mm using five crowns for each angulation. The final restorations were prepared and stored in distilled water at mouth temperature (37°C) for 24 hours prior to testing. The restorations were cemented using Temp Bond