In Vitro genotoxic activities of the aqueous extract from Thai Noni's Leaves (ANL) in human lymphocytes

Ratanavalachai, Treetip; Thitiorul, S; Nandhasri, P.; Tanuchit, Sermkiat; Jansom, Chalerm

doi:10.1055/s-0029-1234685

Cited by 2 publications

(2 citation statements)

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“…Ten studies 24,[63][64][65][66][67][68][69][70][71] reported on the safety and toxicological assessment of M. citrifolia. Table 9 describes the safety implications of Noni investigated on animal toxicity, chronic, and subchronic toxicities as well as cell toxicity studies.…”

Section: Safety and Toxicity Assessmentmentioning

confidence: 99%

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

et al. 2022

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Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.

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Section: Safety and Toxicity Assessmentmentioning

confidence: 99%

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

et al. 2022

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“…Stock solution was diluted with distilled water to 12.5, 25 and 50 mg/ml concentrations. Similar concentrations were used by Ratanavalachai et al (2010). Magnetic stirrer was used to mix the extract homogenously with water.…”

Section: Preparation Of the Aqueous Extractsmentioning

confidence: 99%

Analysis of the mitotic effect of Annona muricata leaf extracts on Allium cepa root tip cells

Bibi¹,

Christi²,

Ferreira³

et al. 2019

Afr. J. Biotechnol.

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There has been a growing interest in medicinal plants by the locals of the Pacific Islands since it is readily available. Annona muricata, commonly called soursop is one of such plants which is popular because it is being used to treat initial stages of cancer due to its antioxidant properties. This study investigated various extraction methods which could be used to compare and see the effectiveness of each on the chromosomes. The cytotoxicity and genotoxicity effect were studied using Allium cepa root tip cells. Eight onion bulbs were subjected to the treatment groups which were made using methanol, water and hexane extracts of A. muricata. Three different concentrations from each extraction solvent were used. The A. cepa root tip cells were subjected for 24 h to three different leaf extractions after left to grow in water. Concentrations of 12.5, 25 and 50 g/L were used. After the treatment, onion bulbs were put back in water to recover. Hence, 5 root tips from each bulb were removed (before treatment, treatment and recovery) with cells undergoing mitosis counted under 400x of a compound microscope. All studied concentrations of A. muricata methanol extract showed significant (p≤0.05) drop in the mean mitotic index when compared with control (mean MI reduced by 9.9, 44.4 and 54.2% for 12.5, 25 and 50 g/L respectively). A. muricata water extract also showed significant differences at 12.5 g/L where mitotic index (MI) was reduced by 8.6%. At 25 g/L, the reduction was by 35.3% and by 42.8% at 50 g/L. Drastic effect (p≤0.05) was observed with the soursop-hexane extract that reduced the MI significantly in 12.5 g/L by 5.0% and by 29.7% at 25 g/L. A huge reduction in MI was observed at 50 g/L where MI declined by 72.8%. Chromosomal aberrations were also observed which indicates the genotoxicity of the extracts. All the extraction methods contributed significantly towards the drop in total MI. Compounds in the extracts is mitodepressive.

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In Vitro genotoxic activities of the aqueous extract from Thai Noni's Leaves (ANL) in human lymphocytes

Cited by 2 publications

References 0 publications

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

Analysis of the mitotic effect of Annona muricata leaf extracts on Allium cepa root tip cells

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