In vitro Hemostatic Functions of Cold-Stored Platelets

Abstract

<b><i>Background:</i></b> Transfusion of platelets is a life-saving medical strategy used worldwide to treat patients with thrombocytopenia as well as platelet function disorders. <b><i>Summary:</i></b> Until the end of 1960s, platelets were stored in the cold because of their superior hemostatic functionality. Cold storage of platelets was then abandoned due to better posttransfusion recovery and survival of room temperature (RT)-stored platelets, demonstrated by radioactive labeling studies. Based on these findings, RT became the standard condition to store platelets for clinical applications. Evidence shows that RT storage increases the risk of septic transfusion reactions associated with bacterial contamination. Therefore, the storage time is currently limited to 4–7 days, according to the national guidelines, causing a constant challenge to cover the clinical request. Despite the enormous efforts made to optimize storage conditions of platelets, the quality and efficacy of platelets still decrease during the short storage time at RT. In this context, during the last years, cold storage has seen a renaissance due to the better hemostatic functionality, reduced risk of bacterial contamination, and potentially longer storage time. <b><i>Key Messages:</i></b> In this review, we will focus on the impact of cold storage on the in vitro platelet functions as promising alternative storage temperature for future medical applications.

A Call to Reinvent Platelet Products

“…One potential way to achieve prolonged platelet storage is to decrease the storage temperature. Irene Marini and colleagues [4] first review in vitro hemostatic functions of cold-stored platelets and show the diverse aspects and challenges associated with cold storage of PCs. Thereafter, Zeller-Hahn et al [5] pinpoint the obstacles of increased platelet responsiveness after shortterm refrigeration in an original work.…”