In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities

Huang, Chenchen; Hu, Keqi; Zeng, Yanhong; Jiang, Yiye; Tian, Yonghui; Luo, Xiao-Jun; Mai, Bi-Xian

doi:10.1016/j.scitotenv.2022.161043

Science of The Total Environment

2023

DOI: 10.1016/j.scitotenv.2022.161043

|View full text |Cite

In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities

Chenchen Huang

Keqi Hu

Yanhong Zeng

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Yang,

Meng,

Zhang

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

There is growing evidence of the frequent detection of tire rubber-derived contaminants p-phenylenediamine-derived quinones (PPD-Qs) (e.g., highly toxic N-(1,3-dimethylbutyl)-N′-phenyl-pphenylenediamine quinone (6PPD-Q)) in the environment and biota and the adverse impact on organisms. Hence, a better understanding of their biotransformation/metabolism in humans is essential. However, relevant data are lacking owing to recent discoveries. Herein, the biotransformation patterns of 6PPD-Q and other five commonly detected PPD-Qs were characterized via combined in vitro assay and maternal cord blood screening monitoring. Rapid metabolism was found for each PPD-Q incubated with human liver S9 fraction and microsomes, resulting in the formation of abundant phase I and phase II metabolites. The subsequent screening for potential PPD-Q metabolites in blood samples showed the presence of suspect metabolites. Three detected metabolites were confirmed by matching the mass spectra and retention times of in vitro metabolites. N-Dealkylated, carboxy, carbonyl, and reductive metabolites and glucose, cysteine, and methionine conjugates were observed for the first time. The semiquantitative concentrations of metabolites were higher than those of the parent PPD-Qs, and several metabolites such as carboxy products were proposed as candidate biomarkers of PPD-Q exposure to humans. 6PPD-Q and N,N′-diphenyl-p-phenylenediamine quinone were detected in maternal and/or cord whole blood samples for the first time. This study holds great importance in elucidating the potential risks and health effects of PPD-Qs.

show abstract

Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Yang,

Meng,

Zhang

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

Aerobic bacterial degradation of polychlorinated biphenyls and their hydroxy and methoxy derivatives

Gorbunova,

Egorova,

Saloutin

et al. 2024

RUSS CHEM REV

View full text Add to dashboard Cite

Polychlorinated biphenyls are persistent organic pollutants hazardous to humans and to the environment. The products of biotransformation of these compounds can exist in natural objects as hydroxy and methoxy derivatives. This review summarizes the biodegradation pathways of polychlorinated biphenyls under the action of aerobic bacterial strains. The possibility of complete biodegradation of polychlorinated biphenyls and their derivatives under laboratory conditions is demonstrated. This information is valuable for researchers specializing in the biotransformations and toxicity of polychloroarene derivatives and would be useful for the development of remediation processes of natural objects contaminated with polychlorinated biphenyls.<br> The bibliography includes 253 references.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities

Cited by 2 publications

References 58 publications

Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Aerobic bacterial degradation of polychlorinated biphenyls and their hydroxy and methoxy derivatives

Contact Info

Product

Resources

About