In Vitro Hydrogen Ion Binding by Cereals

Jalan, K. N.; Maitra, T K; Mahalanabis, Dilip; Agarwal, Saurabh; Chakraborty, Moumita; Chattoraj, D. K.; Moulik, Satya P.

doi:10.1111/j.1365-2621.1977.tb08457.x

Cited by 4 publications

(1 citation statement)

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“…Our studies on in-vitro hydrogen ion binding by different cereals have shown that cooked wholewheat flour and cooked bran have a higher hydrogen ion binding capacity than cooked rice (Jalan et al, 1977). In view of these findings, the present study was designed to investigate the gastric acid secretory response and the buffer capacity of the stomach two hours after a meal in five normal and seven duodenal ulcer subjects, to a rice-and a wheat-based meal similar to the ones consumed by the Eastern and Northern Indian people.…”

mentioning

confidence: 89%

Gastric acid secretion rate and buffer content of the stomach after a rice- and a wheat-based meal in normal subjects and patients with duodenal ulcer.

Jalan¹,

Mahalanabis²,

Maitra³

et al. 1979

Gut

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SUMMARY The study describes gastric acid secretory response to a rice-based and a wheat-based meal over a prolonged period of five hours and buffer content of the stomach in five normal and seven duodenal ulcer subjects from the rice-eating eastern Indian population. The results suggest that (1) the meal-mediated gastric acid secretory response in duodenal ulcer subjects is much higher than in the controls, even though the histamine stimulated response is similar, (2) the type of meal, whether rice and fish based or wheat and meat based, does not influence the acid secretory response, and (3) the duodenal ulcer subjects in this area, two hours after a meal, have a buffer capacity similar to the controls.Duodenal ulcer disease in the Indian subcontinent is more common in the rice-eating belt and uncommon in the wheat-eating areas (Malhotra, 1964). Our studies on in-vitro hydrogen ion binding by different cereals have shown that cooked wholewheat flour and cooked bran have a higher hydrogen ion binding capacity than cooked rice (Jalan et al., 1977). In view of these findings, the present study was designed to investigate the gastric acid secretory response and the buffer capacity of the stomach two hours after a meal in five normal and seven duodenal ulcer subjects, to a rice-and a wheat-based meal similar to the ones consumed by the Eastern and Northern Indian people. Methods SUBJECTSThe study group consisted of 12 male subjects of whom five acted as controls (mean age 26-4 years, range 21-33 years; mean body weight 53 kg, range 41 3-68-5 kg) and the rest were suffering from duodenal ulcer confirmed by radiology, with no outlet obstruction (mean age 36-8 years, range 30-42 years; mean weight 60-8 kg, range 504-74 kg). None of the patients received any treatment before the study.

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mentioning

confidence: 89%

Gastric acid secretion rate and buffer content of the stomach after a rice- and a wheat-based meal in normal subjects and patients with duodenal ulcer.

Jalan¹,

Mahalanabis²,

Maitra³

et al. 1979

Gut

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Miscellaneous Systems

Chattoraj¹,

Birdi²

1984

Adsorption and the Gibbs Surface Excess

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The effect of dietary fibre isolates on gastric secretion, acidity and emptying

Tadesse

1986

Br J Nutr

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1. In six volunteers, the effect of intragastric administration of different water-soluble chemical isolates of dietary fibre on gastric secretion, acidity and emptying was studied.2. At 30 min after administration of the test meals, the stomach contents were completely aspirated and the volume, pH, phenol red concentration, totai titratable acidity and different electrolytes were measured.3. Compared with the control meal, the pH and unionized (combined) hydrogen concentrations were significantly higher (P < 0.05) following most of the fibre-containing meals, while the total titratable acid concentration was not significantly different. None of the fibre-containing meals appreciably altered the volume or type of gastric secretion but had a low-grade variable effect on gastric emptying. 4. It is concluded that most dietary fibre isolates, although having a definite and notable buffering effect on the acid in the stomach, have a minimal effect on gastric secretion and a variable and small effect on gastric emptying.There have been several reports of studies investigating the effects of dietary fibre on different aspects of gastric function (Royal College of Physicians of London, 1980). One of the well-documented observations is the effect of fibre on gastric emptying, but most of the evidence on which it is based is indirect. The few direct studies to date are conflicting and difficult to interpret (McCance et al. 1953;Grimes & Goddard, 1977;Carryer et al. 1982;Holt et al. 1979). Although the reason for the apparent difference in findings is partly due to differences in methodology, of much more importance may be the heterogeneity of the fibre type used and the unavoidable variation in the levels of the different chemical components. Another aspect of gastric function which has attracted attention recently is the effect of fibre on acid secretion. In vitro studies show that fibre, because of its ion-binding properties, binds different acids (McConnell et al. 1974; Jalan et al. 1977). There is also some suggestion from human studies that dietary fibre may have some acid-buffering effect (Lennard-Jones et al. 1968;Jalan et al. 1979). This is further supported by epidemiological observations and by two clinical trials which show that the frequency of duodenal ulcer recurrence was much reduced while on a diet with a high-fibre content (Malhotra, 1978;Rydning et al. 1982). As in gastric emptying, the evidence for the possible action on gastric acidity is mainly indirect and there is a need for standardization of the fibre source. There is also lack of identification of the chemical(s) responsible for this action from the heterogenous mixture that constitutes the entity recognized as dietary fibre.It is desirable to investigate the effect of fibre as eaten, but the chemical complexity of the substance makes interpretation of the results very difficult. Moreover, using fibre in its natural form may introduce other nutrient variables which may have an effect on gastric function. Alternatively, studies using defined chemi...

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In Vitro Hydrogen Ion Binding by Cereals

Cited by 4 publications

References 1 publication

Gastric acid secretion rate and buffer content of the stomach after a rice- and a wheat-based meal in normal subjects and patients with duodenal ulcer.

Gastric acid secretion rate and buffer content of the stomach after a rice- and a wheat-based meal in normal subjects and patients with duodenal ulcer.

Miscellaneous Systems

The effect of dietary fibre isolates on gastric secretion, acidity and emptying

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