In vitro-in vivo biotransformation and phase I metabolite profiling of benzo[a]pyrene in Gulf killifish (Fundulus grandis) populations with different exposure histories

Franco, Marco E.; Ramirez, Alejandro J.; Johanning, Karla; Matson, Cole W.; Lavado, Ramón

doi:10.1016/j.aquatox.2021.106057

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…After exposure of PAHs to aquatic organisms for a long time, the detoxification of pollutants is related to the AHR gene deletion site. The decreased inducibility of the AHR signaling pathway may lead to the down-regulation of bioinvertase, especially CYP1A subtype enzyme [ 42 ]. When PAHs are metabolized in the human body, sites of epoxidation are initially transformed into phenols.…”

Section: Methodsmentioning

confidence: 99%

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Zhao

Zhou

Zhao

et al. 2022

IJERPH

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In this study, 16 PAHs were selected as the priority control pollutants to summarize their environmental metabolism and transformation processes, including photolysis, plant degradation, bacterial degradation, fungal degradation, microalgae degradation, and human metabolic transformation. Meanwhile, a total of 473 PAHs by-products generated during their transformation and degradation in different environmental media were considered. Then, a comprehensive system was established for evaluating the PAHs by-products’ neurotoxicity, immunotoxicity, phytotoxicity, developmental toxicity, genotoxicity, carcinogenicity, and endocrine-disrupting effect through molecular docking, molecular dynamics simulation, 3D-QSAR model, TOPKAT method, and VEGA platform. Finally, the potential environmental risk (phytotoxicity) and human health risks (neurotoxicity, immunotoxicity, genotoxicity, carcinogenicity, developmental toxicity, and endocrine-disrupting toxicity) during PAHs metabolism and transformation were comprehensively evaluated. Among the 473 PAH’s metabolized and transformed products, all PAHs by-products excluding ACY, CHR, and DahA had higher neurotoxicity, 152 PAHs by-products had higher immunotoxicity, and 222 PAHs by-products had higher phytotoxicity than their precursors during biological metabolism and environmental transformation. Based on the TOPKAT model, 152 PAH by-products possessed potential developmental toxicity, and 138 PAH by-products had higher genotoxicity than their precursors. VEGA predicted that 247 kinds of PAH derivatives had carcinogenic activity, and only the natural transformation products of ACY did not have carcinogenicity. In addition to ACY, 15 PAHs produced 123 endocrine-disrupting substances during metabolism and transformation. Finally, the potential environmental and human health risks of PAHs metabolism and transformation products were evaluated using metabolic and transformation pathway probability and degree of toxic risk as indicators. Accordingly, the priority control strategy for PAHs was constructed based on the risk entropy method by screening the priority control pathways. This paper assesses the potential human health and environmental risks of PAHs in different environmental media with the help of models and toxicological modules for the toxicity prediction of PAHs by-products, and thus designs a risk priority control evaluation system for PAHs.

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Section: Methodsmentioning

confidence: 99%

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Zhao

Zhou

Zhao

et al. 2022

IJERPH

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“…Benzo[a]pyrene (B[a]P) is a harmful polycyclic aromatic hydrocarbon (PAH) that is highly toxic and is classi ed as a Group 1 carcinogen. B[a]P is of particular concern due to its persistence, bioaccumulation, and toxic effects on living organisms(Akcha et al, 2000;Franco et al, 2022;Gourlay et al, 2005). The speci c research content could be divided into three main parts as follows Akcha et al, 2000;Banerjee et al, 2023;Chen et al, 2016),.…”

mentioning

confidence: 99%

Bioremediation of common high-molecular-weight polycyclic aromatic hydrocarbons: a bibliometric analysis based on Web of Science via VOSviewer

Tang,

Wu,

Han

et al. 2023

Preprint

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High-molecular-weight polycyclic aromatic hydrocarbons (HMW-PAHs) are an important group of persistent organic pollutants. Bioremediation has emerged as a cost-effective and environmentally friendly technique to remediate HMW-PAH contamination. In this study, we conducted a comprehensive bibliometric analysis using VOSviewer software on a dataset comprising 3009 relevant publications retrieved from the Web of Science database. Our analysis specifically focused on exploring the research landscape of bioremediation strategies for common HMW-PAHs, denoted as BC-HMW-PAHs. By employing cocitation analysis, co-occurrence analysis, and clustering analysis, we unveiled the knowledge foundation of BC-HMW-PAH bioremediation research, with notable contributions from renowned academic journals such as Applied and Environmental Microbiology, Chemosphere, and Environmental Science & Technology. The research in this field is interdisciplinary and includes the fields of environmental science, biotechnology, applied microbiology, microbiology, engineering, and toxicology. The key research themes identified encompass PAHs, biodegradation, benzo[a]pyrene, bioaugmentation, and degradation. Based on insights from our bibliometric analysis, we presented five research recommendations: in-depth exploration of degradation mechanisms for specific HMW-PAHs, thorough comprehension of microbial metabolic pathways, investigation into the toxicity and degradation products of HMW-PAHs, implementation of field experiments and scale-up applications, and establishment of long-term monitoring and assessment protocols.

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Effects of perfluoroalkyl substances (PFASs) and benzo[a]pyrene (BaP) co-exposure on phase I biotransformation in rainbow trout (Oncorhynchus mykiss)

Solan

Franco

Lavado

2022

Fish Physiol Biochem

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In vitro-in vivo biotransformation and phase I metabolite profiling of benzo[a]pyrene in Gulf killifish (Fundulus grandis) populations with different exposure histories

Cited by 4 publications

References 47 publications

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Bioremediation of common high-molecular-weight polycyclic aromatic hydrocarbons: a bibliometric analysis based on Web of Science via VOSviewer

Effects of perfluoroalkyl substances (PFASs) and benzo[a]pyrene (BaP) co-exposure on phase I biotransformation in rainbow trout (Oncorhynchus mykiss)

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