In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

Abstract

Polymeric micelles are widely used as suitable nano-carriers for a variety of therapeutic applications.

Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging

“…4A demonstrates that the as-synthesized DOX@ZIF-8 displayed a positively-charged surface with a zeta potential of 27.1 mV, while PDA modification gives the hybrid nanoparticles a negatively-charged surface owing to the abundant phenolic groups of PDA. 29 After the attachment of acid mucopolysaccharide HA, 30 the obtained DOX@ZIF-HA still maintained a highly negative potential with a value of −30.2 mV. Logically, the higher negative potential could ensure good colloidal stability of the nanomaterials under physiological conditions, 31 resulting in good colloidal stability of DOX@ZIF-HA as illustrated above.…”

Preparation and property of starch nanoparticles reinforced aldehyde–hydrazide covalently crosslinked PNIPAM hydrogels

“…In vitro cytotoxicity test of precursors of hydrogels, fillers of SNPs and H 9.0 hydrogel were assayed using a CCK‐8 assay with L929 fibroblasts cells over 7 days . Results were shown in Figure .…”

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

“…The use of diverse polymers and possibility of their modification allows the encapsulation of almost any substance. Polymeric drug carriers containing cholesterol in their structure are mainly tested for the transport of anti-cancer [16,17,48,[70][71][72], anti-fungal [58,152], antibacterial [117], and anti-inflammatory drugs [44,99,117] as well as antioxidants [15,54,117]. By using cholesterol-containing systems, endocytosis or fusion of siRNA [100] or pDNA [134] is possible.…”

“…A plethora of polymers has been used to obtain carriers with an innumerable variety of physicochemical and biological properties. The most frequently used are biocompatible and biodegradable polymers of natural or synthetic origin such as chitosan (CS) [11][12][13] hyaluronic acid (HA) [13][14][15][16][17], peptides [18], N-(2-hydroxypropyl)methacrylamide (HPMA) [19][20][21][22][23][24][25][26][27], poly(ethylene glycol) (PEG) [25,26,, poly(glutamic acid) (PGA) [53,76,77], poly(lactic acid) (PLA) [28,78,79], and poly(d,l-lactide-co-glycolide) (PLGA) [29,53,80]. Their advantages are low toxicity, reduction of possible side effects, and ease of excretion [3,4,81].…”