In vitro/in vivo evaluation of HPMC/alginate based extended-release matrix tablets of cefpodoxime proxetil

Mujtaba, Ali; Kohli, Kanchan

doi:10.1016/j.ijbiomac.2016.05.010

Cited by 30 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To examine the release kinetics of the optimized formulation, the release data obtained from in vitro drug release studies were plotted in various kinetic models: zero-order, first-order, and Higuchi’s model [39]. From the data analysis in Table 4, the Higuchi models achieved the highest correlations ( R 2 = 0.9546) with obtained data, which were plotted as cumulative percentage drug release versus square root of time.…”

Section: Resultsmentioning

confidence: 99%

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

2017

View full text Add to dashboard Cite

Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of polymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer, adsorbent (colloidal silicon dioxide), and additional polymers—sodium carboxymethyl cellulose (SCMC), hydroxypropyl methylcellulose (HPMC)—was varied systematically to adjust the drug loading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS. The optimum composite sponge was fabricated from a 4% alginate and 2% HPMC mixed solution. It immediately floated on simulated gastric fluid (SGF, pH 1.2) and remained buoyant over an 8 h period. The formulation exhibited an emulsion droplet size of approximately 30 nm and provided sustained release of Cur-SMEDDS in SGF, reaching 71% within 8 h compared with only 10% release from curcumin powder. This study demonstrates the potential of alginate-based composite sponges combined with self-microemulsifying formulations for gastroretention applications involving poorly soluble compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

2017

View full text Add to dashboard Cite

show abstract

“…This initial release from BNPs could be most probably because of the presence of the drug on the surface of NPs or due to the diffusion of the drug from the pores, which are nearer to the surface of NPs [28]. Since NPs have a larger surface-area-to-volume ratio, such geometry is also favored for fast release [29]. To determine the release order, the in vitro release profile of the BNPs was kinetically analyzed.…”

Section: In Vitro Drug-release Kineticsmentioning

confidence: 99%

Development of Natural Polysaccharide–Based Nanoparticles of Berberine to Enhance Oral Bioavailability: Formulation, Optimization, Ex Vivo, and In Vivo Assessment

et al. 2021

Self Cite

View full text Add to dashboard Cite

The phytogenous alkaloid berberine (BBR) has become a potential drug for the treatment of diabetes, hyperlipidemia, and cancer. However, its therapeutic potential is limited because ofpoor intestinal absorption due to its efflux by the P-gp expressed in the intestinal lumen. Therefore, we aimed to design and fabricate a nanoparticulate system for delivery of BBR employing naturally derived biodegradable and biocompatible polymers, mainly chitosan and alginate, to enhance the oral bioavailability of BBR. A chitosan-alginate nanoparticle system loaded with BBR (BNPs) was formulated by ionic gelation method and was optimized by employing a three-factor, three-level Box-Behnken statistical design. BNPs were characterized for various physicochemical properties, ex vivo, and in vivo evaluations. The optimized BNPs were found to be 202.2 ± 4.9 nm in size, with 0.236 ± 0.02 of polydispersity index, zeta potential −14.8 ± 1.1 mV, and entrapment efficiency of 85.69 ± 2.6%. BNPs showed amorphous nature with no prominent peak in differential scanning calorimetry (DSC) investigation. Similarly, fourier-transform infrared spectroscopy (FTIR) studies did not reveal any interaction between BBR and excipients used. The drug release followed Higuchi kinetics, since these plots demonstrated the highest linearity (R2 = 0.9636), and the mechanism of release was determined to be anomalous or non-Fickian in nature. An ex-vivo gut permeation study showed that BNPs were better internalized into the cells and more highly permeated through the intestine. Furthermore, in vivo pharmacokinetic analysis in female Wistar rats showed a 4.10−fold increase in the oral bioavailability of BBR from BNPs as compared to BBR suspension. With these findings, we have gained new insight into the effective delivery of poorly soluble and permeable drugs via a chitosan-alginate nanoparticle system to improve the therapeutic performance of an oral nanomedicine.

show abstract

“…All methods should be properly validated and/or verified before the routine application. [18][19][20][21] The aim of the study…”

Section: Evolution Of Methodologymentioning

confidence: 99%

“…Peaks of standard additions method in concentrations (4.6, 6.85, and 9.1) and peaks height(20,27, and 34 mm), respectively…”

mentioning

confidence: 99%

Untitled

Al-Salman¹

2018

AJP

View full text Add to dashboard Cite

Context: Cephradine is the most important type of antibiotics used vary widely. Analysis of these antibiotics is the challenge because of their sensitivity and instability to different conditions. Objective: The present article is extended to find out HPLC method. Materials and Methods: The Standard Solution 100 µg/ml Cephradine was prepared by dissolving accurately weight 100 mg of Cephradine in 1000 ml methanol and the range 2.5-12.5 µg/ml was prepared by serial dilution of the sample with methanol. HPLC-UV system with Ion Pac column Zorbax 300-SCX Agilent Column; 5µm, 4.6×250 mm used for analysis for Cephradine in formulations capsules. The chromatographic conditions used for the analysis as well as analytical parameters study carried out with experimental conditions. HPLC method is the most common method for the analysis of Cephradine in formulation and in biological fluids, the several analytical procedures have been described for analysis of Cephradine in different pharmaceutical the formulations. Result and Discussion: During the study analytical parameters studied such as range, linearity, precision, accuracy, LLOD, LLOQ. Cephradine as formulation capsules was almost stable at room temperature up to 2-3 days in the aqueous medium at pH between 4 and 5. The focus of the study of analysis of Cephradine in formulation capsules is used for the determination of various Cephradine for supported by budding researchers. Conclusion: This study suggested a simple, easy and highly sensitive method using standardized samples obtained from the best international companies. Comparisons were made with different commercial samples of cephradine antibiotics. The actual ratios of cephradine were determined in commercial pharmaceuticals.

show abstract

In vitro/in vivo evaluation of HPMC/alginate based extended-release matrix tablets of cefpodoxime proxetil

Cited by 30 publications

References 19 publications

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

Development of Natural Polysaccharide–Based Nanoparticles of Berberine to Enhance Oral Bioavailability: Formulation, Optimization, Ex Vivo, and In Vivo Assessment

Untitled

Contact Info

Product

Resources

About