In Vitro Inactivation of Herpes Virus by Ozone

Petry, Greici; Rossato, Luciana; Nespolo, Jaqueline; Kreutz, Luiz Carlos; Bertol, Charise Dallazem

doi:10.1080/01919512.2013.862165

Cited by 23 publications

(24 citation statements)

References 17 publications

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“…Three articles were found to support the antiviral activity of ozone: one is an in vitro study which showed that ozone can inactivate herpes simplex virus type 1 (HSV-1) ( Petry et al, 2014 ) and two articles describing clinical studies with the aim of evaluating antiviral activity against hepatitis C virus (HCV) ( Zaky et al, 2011 ; mn and tt, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

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Ozone therapy in COVID-19: A narrative review

et al. 2021

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Highlights Ozone therapy seems to have an immunological role within SARS-CoV-2 regimens, because of the modulation of cytokines and interferons, including the induction of gamma interferon. Ozone exerts antiviral activity through the inhibition of viral replication and direct inactivation of viruses. Ozone is an antiviral drug enhancer and is not an alternative to antiviral drugs. The routes of ozone administration are direct intravenous, major autohaemotherapy and extravascular blood oxygenation-ozonation. Combined treatment with involving ozone and antivirals demonstrated a reduction in inflammation and lung damage.

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Section: Resultsmentioning

confidence: 99%

“…The aim of the in vitro study ( Petry et al, 2014 ) was to evaluate the antiviral activity of ozone against the herpes virus and its possible cytotoxic effect on cultured Madin-Darby bovine kidney (MDBK) cells. Experiments were performed in a laminar flow chamber, and ozone was generated by a commercial air purifier.…”

Section: Resultsmentioning

confidence: 99%

Ozone therapy in COVID-19: A narrative review

et al. 2021

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“…As a side effect, corona discharges also generate ozone, which is known to inactive viruses 32,33 . A positive charge was used in the electrostatic precipitator because it produces less ozone than a negative charge 34,35 .…”

Section: (Figmentioning

confidence: 99%

Comparison of three air samplers for the collection of four nebulized respiratory viruses

Kutter

Meulder

Bestebroer

et al. 2020

Preprint

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Viral respiratory tract infections are a leading cause of morbidity and mortality worldwide. Unfortunately, the transmission routes and shedding kinetics of respiratory viruses remain poorly understood. Air sampling techniques to quantify infectious viruses in the air are indispensable to improve intervention strategies to control and prevent spreading of respiratory viruses. Here, the collection of infectious virus with the six-stage Andersen cascade impactor was optimized with semi-solid gelatin as collection surface. Subsequently, the collection efficiency of the cascade impactor, the SKC BioSampler, and an in-house developed electrostatic precipitator was compared. In an in-vitro setup, influenza A virus, human metapneumovirus, parainfluenza virus type 3 and respiratory syncytial virus were nebulized and the amount of collected infectious virus and viral RNA was quantified with each air sampler. Whereas only low amounts of virus were collected using the electrostatic precipitator, high amounts were collected with the BioSampler and cascade impactor. The BioSampler allowed straight-forward sampling in liquid medium, whereas the more laborious cascade impactor allowed size fractionation of virus-containing particles. Depending on the research question, either the BioSampler or the cascade impactor can be applied in laboratory and field settings, such as hospitals to gain more insight into the transmission routes of respiratory viruses.Practical ImplicationsRespiratory viruses pose a continuous health threat, especially to vulnerable groups such as young children, immunocompromised individuals and the elderly. It is important to understand via which routes these viruses can transmit to and between individuals that are at risk. If we can determine the amount of a certain respiratory virus in the air, then this will help to predict the importance of transmission through the air for this virus. Most currently available air sampling devices have not been designed to collect infectious viruses from the air. Therefore, we here optimized and compared the performance of three air samplers for four different respiratory viruses.

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“…Viability of HSV-1 and Bovine herpesvirus (BHV) was shown to be reduced by 2 logs and more than 3 logs, respectively, after application of ozone from a domestic device for a period of three hours (Petry et al, 2014). Schneider et al (1990) showed an average of 8 log reduction of Vibrio vulnificus using an initial ozone concentration of 5.3 mg/L.…”

Section: Ozonementioning

confidence: 99%