In vitro induction of anti-type 2 T cells by glycyrrhizin

Nakajima, Natsuki; Utsunomiya, T.; Kobayashi, Makiko; Herndon, David N.; Pollard, Richard B.; Suzuki, Fujio

doi:10.1016/s0305-4179(96)00053-8

Cited by 17 publications

(32 citation statements)

References 28 publications

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“…It has various biological activities including: induction of IFN-Á production [10], augmentation of NK cell activity [11], inhibition of inflammation [12] and suppression of herpesvirus replication [13]. In addition, GR is capable of inducing anti-type-2 T cells [14] and improving the resistance of hosts exposed to certain opportunistic pathogens [15]. Recently, GR was shown to be an inducer of ß-chemokines.…”

Section: Introductionmentioning

confidence: 99%

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

et al. 2002

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The effect of glycyrrhizin (GR) on HIV replication in cultures of peripheral blood mononuclear cells (PBMC) from HIV-infected patients was investigated. After the depletion of CD8+ T cells, PBMC from HIV+ patients (patient PBMC) and PBMC from healthy donors (healthy PBMC) were cocultured in the presence or absence of GR (100 µg/ml) for 21 days. In cultures of 13 of 42 samples of patient PBMC (13/42, 31%), GR inhibited more than 90% of HIV replication. Among 42 samples of patient PBMC, 20 were identified to be infected with a non-syncytium-inducing variant of HIV (NSI-HIV), 15 with a syncytium-inducing variant of HIV (SI-HIV), and the remaining 7 were classified as cells infected with SI-HIV and/or NSI-HIV. GR inhibited more than 90% of HIV replication in cultures of 12 patient PBMC samples infected with NSI-HIV (12/20, 60%). In patient PBMC infected with SI-HIV, GR inhibited HIV replication in only 1 patient (1/15, 7%). In cultures of patient PBMC, GR induced the production of CC chemokine ligand (CCL)4 and CCL5 in a dose-dependent manner. When the assay was performed in PBMC cultures supplemented with a mixture of monoclonal antibodies for CCL4 and CCL5, no evidence of anti-HIV activity of GR was found. These results indicate that GR has the potential to inhibit NSI-HIV replication in patient PBMC cultures by inducing the production of β-chemokines.

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Section: Introductionmentioning

confidence: 99%

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

et al. 2002

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“…Also, burn-associated impairment of interleukin-12 (IL-12) responsiveness was recovered in thermally injured mice treated with GR (10). GR has been shown to be an inducer of type 2 antagonistic CD4 ϩ T cells (9,11,12), which have the ability to inhibit the production of IL-4 and IL-10 by burn-associated CD8 ϩ type 2 T cells (11,13). Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12).…”

Section: Introductionmentioning

confidence: 99%

“…GR has been shown to be an inducer of type 2 antagonistic CD4 ϩ T cells (9,11,12), which have the ability to inhibit the production of IL-4 and IL-10 by burn-associated CD8 ϩ type 2 T cells (11,13). Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12). They were different from the other CD4 ϩ T cell subsets, such as Th1 cells and Th2 cells, by their cytokine-producing profiles and adherence to V. villosa lectin (9,11,13).…”

Section: Introductionmentioning

confidence: 99%

“…Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12). They were different from the other CD4 ϩ T cell subsets, such as Th1 cells and Th2 cells, by their cytokine-producing profiles and adherence to V. villosa lectin (9,11,13). In addition, they showed no helper cell activity when they were subjected to the hemolysin production assay (13).…”

Section: Introductionmentioning

confidence: 99%

“…These cells peaked 2 days after the last GR treatment (9). They were also generated in vitro when splenic mononuclear cells (SMNC) of normal mice were cultured with 0.1-10 g/ml of GR under regulation of the presence of macrophages (11).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Utsunomiya

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Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Nassiri‐Asl

Hosseinzadeh

2008

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The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components.

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In vitro induction of anti-type 2 T cells by glycyrrhizin

Cited by 17 publications

References 28 publications

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

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