2005
DOI: 10.1007/s10156-004-0370-y
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In vitro induction of resistance to metronidazole, and analysis of mutations in rdxA and frxA genes from Helicobacter pylori isolates

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Cited by 16 publications
(3 citation statements)
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“…In contrast to other studies that concluded that mutations in frxA without mutations in rdxA might cause metronidazole resistance (22,24,40), we suggested that this may be due to other additional but uncharacterized mechanisms of metronidazole resistance that coexist with the mutations in the frxA gene (24).…”
Section: Discussioncontrasting
confidence: 99%
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“…In contrast to other studies that concluded that mutations in frxA without mutations in rdxA might cause metronidazole resistance (22,24,40), we suggested that this may be due to other additional but uncharacterized mechanisms of metronidazole resistance that coexist with the mutations in the frxA gene (24).…”
Section: Discussioncontrasting
confidence: 99%
“…The wild-type H. pylori strain 26695 (denoted 26695-1 in our previous study [32] and susceptible to metronidazole) was obtained from a subculture of the original 26695 strain purchased from the American Type Culture Collection (ATCC). A metronidazole-resistant strain was cultured from strain 26695-1 after exposure to low concentrations of metronidazole, as described previously (24,32,33). Briefly, a single colony of 26695-1 was inoculated onto Mueller-Hinton II agar (Becton Dickinson, Sparks, MD, USA) supplemented with 10% defibrinated horse blood (Nippon Biotest Lab, Tokyo, Japan) without antibiotics.…”
Section: Methodsmentioning
confidence: 99%
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