In Vitro Inhibition of Evaporation with Perfluorohexyloctane, an Eye Drop for Dry Eye Disease

A Review of the First Anti-Evaporative Prescription Treatment for Dry Eye Disease: Perfluorohexyloctane Ophthalmic Solution

“…16,17,[35][36][37][38][39][40] PFHO is a physiologically inert, semifluorinated alkane consisting of 6 perfluorinated and 8 hydrogenated carbons; it therefore has amphiphilic properties, allowing it to form a monolayer at the tear film air-liquid interface when applied topically (Figure 2 35,41 ). [16][17][18] PFHO is a liquid at temperatures above -7.1 °C, and it does not scatter or absorb visible light; with a refractive index similar to water, PFHO is associated with minimal blurred vision. 16,19,35,42 The anti-evaporative effect of PFHO was demonstrated in a series of in vitro gravimetric assays.…”

“…1,[10][11][12][13][14][15] Perfluorohexyloctane (PFHO) ophthalmic solution (MIEBO™; Bausch + Lomb) is the first and only FDA-approved treatment for DED that directly targets tear evaporation by supplementing the tear film lipid layer in patients whose tear evaporation exceeds tear production. 16,17 PFHO is a water-free, preservative-free, single-ingredient prescription eye drop approved to treat the signs and symptoms of DED. 18 Approval of PFHO was based on the results of 2 pivotal phase 3, multicenter, randomized clinical trials (RCTs), GOBI (NCT04139798) and MOJAVE (NCT04567329).…”

Seeing the Future: A Review of Ocular Therapy

“…A common delivery modality for ocular therapeutics to treat anterior segment diseases, such as dry eye and glaucoma, is through eye drops [173,174,177]. The major disadvantage with eye drops is the leakage through the lacrimal system, an issue that can be resolved through the use of nanoparticle formulations.…”

“…Most of the current treatments for ocular surface diseases are eye drop formulations, including Miebo, Restasis, a cyclosporin drug, and Eysuvis, an ophthalmic suspension with loteprednol etabonate, all of which are FDA-approved treatments for dry eye disease [173][174][175][176]. Approved eye drops for use in glaucoma include prostaglandins such as latanoprost, travoprost, tafluprost, and bimatoprost, as well as Rho kinase inhibitors such as Netarsudil [177,178].…”

Influence of perfluorohexyloctane (Evotears®) on higher order aberrations

“…This regularization of the corneal surface and stabilization of the tear film could explain the increase in measurement accuracy demonstrated in our current study. On the one hand, we noticed an increase of HOA after long-term application of F6H8, which could be related to the lower tear evaporation with F6H8 [ 33 ]. On the other hand, its regulating effects on the corneal surface leads to increased repeatability of the obtained refractive and aberrometric values.…”