In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide

Civitelli, Livia; Panella, Simona; Marcocci, Maria Elena; Petris, Alberto De; Garzoli, Stefania; Pepi, Federico; Vavala, Elisabetta; Ragno, Rino; Nencioni, Lucia; Palamara, Anna Teresa; Angiolella, Letizia

doi:10.1016/j.phymed.2014.01.013

Cited by 73 publications

(63 citation statements)

References 37 publications

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“…It is also known that the essential oil from Mentha suaveolens has antimicrobial and antioxidant properties. According to its phytochemical analyses, the plant is rich in piperitenone, piperitone oxides, terpenic alcohol and other derivate compounds (Civitelli et al 2014). …”

Section: Introductionmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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“…In this sense, Iqbal et al (2013) reported that the most abundant constituents in Mentha longifolia L. (Lamiaceae) EO were piperitenone oxide (28.3%) and piperitenone (24.9%), and they showed that the AA of its EO was similar to the piperitenone activity. Civitelli et al (2014) reported that piperitenone oxide exerted a strong inhibitory effect against herpes simplex virus type 1 (HSV-1). HSV-1 infection is known to induce a prooxidative state, and this redox change in the cell is important for viral replication.…”

Section: Antioxidant Activity Versus Phytochemical Compositionmentioning

confidence: 99%

Antioxidant activity and chemical composition of essential oils of three aromatic plants from La Rioja province

Barbieri

Costamagna

Gilabert

et al. 2015

Pharmaceutical Biology

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Context: The use of many traditional medicinal plants is often hampered by the absence of a proper biochemical characterization, which is essential to identify the bioactive compounds present in it. The essential oils (EOs) of three native species from the La Rioja province were analyzed: Lippia turbinata Griseb and Lippia integrifolia (Griseb.) Hieron (Verbenaceae), and Clinopodium gilliesii (Benth.) Kuntze (Lamiaceae). Objective: The aim of this study was to evaluate their EOs antioxidant activity (AA) and their chemical composition. Materials and methods: EOs were analyzed by gas chromatography-mass spectrometry (GC-MS).To enhance the aqueous solubilization of the EOs, EO-water emulsions were prepared (concentration range of 0.1-6 mg mL À1 ). AA was determined using ABTS, DPPH, and peroxyl radical scavenging assays, as well as by the b-carotene bleaching test. Results: Piperitenone oxide was a major constituent in L. turbinata, pulegone and piperitenone oxide in C. gilliesii, and b-caryophyllene in L. integrifolia. Lippia turbinata EO was the most active ABTS and DPPH radical scavenger (SC 50 values of 0.40 ± 0.14 and 0.74 ± 0.08 mg mL À1 , respectively). Clinopodium gilliesii EO exhibited the highest hydrogen peroxide scavenging activity (SC 25 value ¼ 1.52 ± 0.27 mg mL À1). In the b-carotene assay, L. turbinata EO was more effective at inhibiting lipid peroxidation than the other two oils (IC 25 value ¼ 0.15 ± 0.04 mg mL À1 ). Conclusion: Our results suggest that the AA observed can be justified by the presence of oxygenated monoterpenes, mainly piperitenone oxide. Finally, L. turbinata EO might be used as a safe natural antioxidant and food preservative in the food and cosmetic industries.

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“…It is known that different acute and chronic viral infections, including that of Herpes virus, induce a drop of GSH levels in infected cells which favors viral propagation [5,17,18]. The administration of GSH or GSH derivative strongly inhibits virus replication by affecting specific steps of virus lifecycle and restores the GSH content in infected cells.…”

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confidence: 99%

A Polyphenol Rich Extract from <em>Solanum melongena</em> L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex virus Type 1 Activity <em>In Vitro</em>

Sotto

Giacomo

Amatore

et al. 2018

Preprint

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DR2B and DR2C extracts, from peel of commercially and physiologically ripe eggplants, were studied for the antioxidative cytoprotective properties and anti-HSV-1 activity, in line with the evidence that several antioxidants can impair viral replication by maintaining reducing conditions into the host cells. The antioxidative cytoprotective effects against tBOOH-induced damage was assessed in Caco2 cells, while the antiviral activity was studied in Vero cells; phenolic and anthocyanin fingerprint was characterized by integrated phytochemical methods. Results highlighted different compositions of the extracts, with chlorogenic acid and delphinidin-3-rutinoside as the major constituents; other peculiar phytochemicals were also identified. DR2C resulted able to partly counteract the tBOOH-induced cytotoxicity, with a remarkable lowering of lactate metabolism under both normoxia and hypoxia. DR2B and DR2C reduced ROS production, possessed scavenging and chelating properties. Interestingly, DR2C increased intracellular GSH levels. Furthermore, DR2Cinhibited the HSV-1 replication when added for 24 h after viral adsorption, as also confirmed by the reduction of many viral proteins expression. Since DR2C was able to reduce NOX4 expression during HSV-1 infection, its antiviral activity may be correlated to its antioxidant properties. Although further studies are needed to better characterize DR2C activity, the results suggest this extract as a promising new anti-HSV-1 agent.

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In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide

Cited by 73 publications

References 37 publications

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Antioxidant activity and chemical composition of essential oils of three aromatic plants from La Rioja province

A Polyphenol Rich Extract from <em>Solanum melongena</em> L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex virus Type 1 Activity <em>In Vitro</em>

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