In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily

Biological effects ofByrsocarpus coccineus in vitro

“…In African countries and developing countries of other continents of the world, self-medication and combination therapy using western medicines and traditional herbal medicines are frequent (Agbonon et al, 2010), based on personal conviction of synergistic or additive pharmacological effect (Pekthong et al, 2008). Patients often do not report herbal and alternative medicine use to physicians (Shakeel et al, 2010), but there are a number of examples where interactions between herbal medicines and drugs can be clinically significant.…”

Possible mechanisms of action of the aqueous extract ofArtocarpus altilis(breadfruit) leaves in producing hypotension in normotensive Sprague–Dawley rats

“…The aqueous extract of A. altilis inhibited CYPs3A4 and 2D6 enzyme activities in the sub mg/mL levels, which appear to be poor in potency. Other medicinal plant extracts have been noted to have IC 50 values ranging between 0.1 mg/mL (Shields et al, 2009) and more potent values of less than 0.01 mg/mL (Tam et al, 2009;Agbonon et al, 2010). Although conclusive determinations can only be drawn from clinical studies, the weak inhibition displayed by the A. altilis extract in this in vitro investigation is indicative of a fairly low likelihood of clinically observable adversities through CYPs3A4 and 2D6 mediated metabolism.…”

In Vivo Effect of Ruta Chalepensis Extract on Hepatic Cytochrome 3a1 in Rats

“…This is a possible explanation to the results found by Pan et al (2011), who concluded that the petroleum ether (PE) extract of Orthosiphon stamineus produces the greatest inhibitor effect on CYP2C19. At the time this experiment was published, there were no other studies on R. chalepensis extract in cytochromes available to compare our results; however, previous research reports on the study of other plants, such as Andrographis paniculata (Pekthong et al, 2009), Orthosiphon stamineus, Aframomum cuspidatum (Agbonon et al, 2010), and Centella asiatica (Pan et al, 2011) in cell culture. Centella asiatica was also studied in vivo by Kulthong et al, (2009).…”