In Vitro Inhibitory Effect of Succinic Acid on T-Cell Acute Lymphoblastic Leukemia Cell Lines

Ertuğrul, Barış; İplik, Elif Sinem; Çakmakoğlu, Bedia

doi:10.1016/j.arcmed.2020.10.022

Cited by 7 publications

(6 citation statements)

References 39 publications

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“…Shikimic acid, an example of an organooxygen compound, was linked to therapeutic effects in osteoarthritis [135]. Metabolites of other classes, such as succinic and stearic acids, presented an apoptotic effect in T-cell acute lymphoblastic leukemia and antifibrotic activity, respectively [136,137]. Flavonoids and isoflavonoids, such as 7,4 -dihydroxyflavone and glycitin, presented activity against lung diseases [138,139].…”

Section: Branchesmentioning

confidence: 99%

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Bragagnolo

Funari

Ibáñez

2021

Foods

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The valorization of agri-food by-products is essential from both economic and sustainability perspectives. The large quantity of such materials causes problems for the environment; however, they can also generate new valuable ingredients and products which promote beneficial effects on human health. It is estimated that soybean production, the major oilseed crop worldwide, will leave about 597 million metric tons of branches, leaves, pods, and roots on the ground post-harvesting in 2020/21. An alternative for the use of soy-related by-products arises from the several bioactive compounds found in this plant. Metabolomics studies have already identified isoflavonoids, saponins, and organic and fatty acids, among other metabolites, in all soy organs. The present review aims to show the application of metabolomics for identifying high-added-value compounds in underused parts of the soy plant, listing the main bioactive metabolites identified up to now, as well as the factors affecting their production.

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Section: Branchesmentioning

confidence: 99%

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Bragagnolo

Funari

Ibáñez

2021

Foods

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“…Nine (9) of the latter metabolites (asparagine, glycine, valine, phenylalanine, isoleucine, succinic acid, fumaric acid, N-acetyl-aspartic acid and N-acetyl-glutamic acid) have been shown to promote tumor growth and/or metastasis in various types of cancer and leukemia [ 32 - 45 ]. While dual roles have been reported for isoleucine and succinic acid [ 46 - 48 ]. And five (5) of the thirteen (13) metabolites are glucogenic amino acids (asparagine, b-alanine, glycine, valine and phenylalanine) [ 49 ] an observation consistent with gluconeogenesis being one the three main enriched processes ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, nine (9) of the latter metabolites (asparagine, glycine, valine, phenylalanine, isoleucine, succinic acid, fumaric acid, N-acetylaspartic acid and N-acety l -glutamic acid) have been shown to promote tumor growth and/or metastasis in various types of cancer (non-small cell lung cancer, breast cancer, multiple myeloma, melanoma, pancreatic cancer, colorectal cancer, lymphoma, ovarian and brain tumors) and leukemia [ 32 - 45 ]. While dual roles have been reported for isoleucine and succinic acid [ 46 - 48 ]. In the case of asparagine, it promotes tumor progression and growth in non-small-cell lung cancer, ALL [ 32 ] and metastasis in breast cancer [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Rodríguez-Vázquez,

Diaz-Quiñones,

Chorna

et al. 2023

Biomedicine & Pharmacotherapy

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“…This antiproliferative effect of the WSR extract is related to its content of anticancer components (Table 1). Based on the previous finding, succinic acid (68.52%) revealed an apoptotic effect on acute lymphoblastic leukemia (T-ALL cell line) and increased caspase-3 activity in human leukemic lymphoblasts (CCRF-CEM cell line) in vitro (30). Additionally, anthranilic acid (16.87%) has been widely used with its derivatives to fight cancer and it has an antiproliferative effect (31).…”

Section: Discussionmentioning

confidence: 97%

Combination of Ashwagandha Water Extract and Intermittent Fasting as a Therapy to Overcome Cisplatin Resistance in Breast Cancer: An in vitro and in vivo Study

Jawarneh

Talib

2022

Front. Nutr.

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Breast cancer is considered a universal public health dilemma in women. Due to the high toxicity and low selectivity of conventional anticancer therapies, there is a growing trend of using plant-derived natural products in cancer prevention and therapy. Ashwagandha (Withania somnifera, WS) has been used in the Mediterranean region and Ayurvedic medicine for millennia as a functional food and a medicinal plant with anticancer activity. Besides, intermittent fasting (IF) has been engaged recently in cancer treatment. Hence, the combination of WS and IF provides possible solutions to treat cancer and reduce chemoresistance when combined with chemotherapy. In this study, WS root (WSR), IF, and cisplatin were tested on cisplatin-sensitive (EMT6/P) and cisplatin-resistant (EMT6/CPR) mouse mammary cell lines. The phytochemical content of the WSR extract was analyzed using liquid chromatography–mass spectrometry (LC-MS) analysis. Antiproliferative and apoptotic effects were assessed for WSR extract, cisplatin, and their combination in vitro using [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide] (MTT) and caspase-3 assays. An in vivo study was used to assess the effect of WSR extract, IF, cisplatin, and their combinations in mice inculcated with EMT6/P and EMT6/CPR cells. The safety profile was also investigated using liver enzymes and creatinine assays. In vitro, WSR extract and cisplatin had a synergistic effect in both cell lines. The same combination induced an apoptotic effect higher than the single treatment in both cell lines. In vivo, several combinations of WSR extract, IF, or cisplatin caused significant tumor size reduction and improved the cure rate in mice implanted with EMT6/P and EMT6/CPR cell lines. IF-treated groups showed a significant reduction in serum glucose and an elevation in β-hydroxybutyrate (BHB) levels. In the safety profile, WSR extract, IF, and their combinations were safe. Overall, the combination of WSR extract and IF provides a promising solution for breast cancer treatment besides cisplatin by reducing the proliferation of cancer cells through induction of apoptosis. Moreover, they minimize cisplatin toxicity to the liver and kidney.

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In Vitro Inhibitory Effect of Succinic Acid on T-Cell Acute Lymphoblastic Leukemia Cell Lines

Cited by 7 publications

References 39 publications

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Combination of Ashwagandha Water Extract and Intermittent Fasting as a Therapy to Overcome Cisplatin Resistance in Breast Cancer: An in vitro and in vivo Study

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