In Vitro Insulin Release from Thermosensitive Chitosan Hydrogel

Khodaverdi, Elham; Tafaghodi, Mohsen; Ganji, Fariba; Abnoos, Khalil; Naghizadeh, Hanie

doi:10.1208/s12249-012-9764-9

Cited by 69 publications

(43 citation statements)

References 22 publications

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“…Cs-GP system has a great potential as scaffold material in tissue engineering and regenerative medicine due to its good biocompatibility, minimal immune reaction, high antibacterial nature, good adhesion to cells and the possibility to be moulded in various geometries [18][19][20][21][22][23][24][25][26]. For similar reasons, the other key pharmaceutical application of this material is a smart-controlled release system [4,18,20,[27][28][29][30][31][32][33][34][35][36][37][38], because the hydrogel is able to keep the drug level within the therapeutic window during extended periods of time, thus avoiding frequent low doses and undesirable secondary effects in patients. Important and interesting patents of biomedical applications of this system have been revised recently [39].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

View full text Add to dashboard Cite

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“…The gelation process was found to be dependent on factors such as concentration of the gel constituents and degree of deacetylation of the chitosan [46]. For instance, increase in deacetylation of chitosan has shown to significantly decrease the gelation time [50]. Scanning electron microscopy (SEM) analysis showed that the hydrogel had a pore size of 40-80 µm.…”

Section: Thermogelling Hydrogelsmentioning

confidence: 99%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

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Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

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“…Chitosan is known to have good biocompatibility, antibacterial, antimicrobial, antiviral and anticancer properties, as well as being biodegradable (27)(28)(29). Furthermore, chitosan has been approved by the Food and Drug Administration (FDA) for application as a wound dressing.…”

Section: A B Cmentioning

confidence: 99%

Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines

Ning

Zhao

Pang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the feasibility of the non-adhesive temperature-sensitive liquid embolic material, chitosan/β-glycerophosphate (C/GP), in embolizing the basicranial rete mirabile (REM) in a swine model of cerebral arteriovenous malformation (cAVM). A total of 24 domestic swines were used as the experimental animals, among which 12 pigs underwent direct embolization of one side of the REM, while the other 12 pigs underwent embolization of the bilateral REM following anastomosis of the carotid artery and jugular vein. A super-selective microcatheter was introduced into the REM during the embolization procedure, and the C/GP hydrogel was injected until an image of the REM disappeared in the angiography examination. Further angiography examinations were performed after 2 and 6 weeks, and histological examination of the REM was performed after 6 weeks. Of the 24 domestic swines, 23 cases underwent successful thrombosis. Convulsions occurred in one case and that pig died during the embolization procedure. Following embolization, the angiography observations revealed that the embolized REM was no longer able to be developed, and adhesion of the microcatheter tip with the embolic agent did not occur. In addition, no apparent revascularization was observed in the angiography examinations performed at weeks 2 and 6. Therefore, the current preliminary study indicated that use of the non-adhesive temperature-sensitive embolic material was feasible for the embolization of cAVM; thus, C/GP may be used as an ideal embolic material for the treatment of cAVM. IntroductionCerebral arteriovenous malformation (cAVM) is the major cause of intracranial hemorrhage and seizures in young and middle-aged adults, and can seriously threaten their quality of life and life expectancy (1,2). Due to the minimal harm inflicted on patients, endovascular embolization therapy has become an important method for the treatment of cAVM, and the selection of an embolic material is a major determinant towards the treatment efficacy.The ideal cAVM embolic material should have a number of characteristics. Firstly, the material should be liquid, since this enables easy control, good dispersibility and ensures a sufficient injection time. Secondly, the material should exhibit a permanent embolism effect. Finally, the material should be non-toxic. Therefore, a non-adhesive liquid embolic material is ideal. In recent years, this particular material had received considerable attention in the field of endovascular treatment (3).Therefore, the present study investigated chitosan/β-glycerophosphate (C/GP) as the base material. The C/GP solution is liquid at room temperature, but forms a hydrogel at 37.0˚C (body temperature). In addition, the pH of the C/GP solution is compatible with the physiological requests. These two materials have been previously demonstrated to be safe and non-toxic (4); however, the combination of C/GP has not been utilized in previous studies as a non-adhesive temperature-sensitive liquid embolic mat...

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In Vitro Insulin Release from Thermosensitive Chitosan Hydrogel

Cited by 69 publications

References 22 publications

Chitosan-Based Thermosensitive Materials

Chitosan-Based Thermosensitive Materials

Chitosan Hydrogels for Regenerative Engineering

Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines

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