In Vitro Interaction Between Spiramycin and Polymorphonuclear Neutrophils Oxidative Metabolism

Moutard, I.; Gressier, Bernard; Brunet, C.; Dine, T.; Luyckx, M.; Templier, F.; Cazin, M.; Cazin, J. C.

doi:10.1006/phrs.1998.0292

Cited by 5 publications

(3 citation statements)

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“…At therapeutic levels, macrolides do not show clear effects on neutrophil function [57,74,75], yet some evidence suggests a slight induction of ROS production [54,74,76,77,78]. However, at higher doses or longer exposure times, an inhibitory effect on ROS production becomes prominent [30,54,74,76,77,78,79,80]. No consensus is reached on the underlying mechanism of the inhibitory effect.…”

Section: Resultsmentioning

confidence: 99%

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

et al. 2019

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Neutrophils are important assets in defense against invading bacteria like staphylococci. However, (dysfunctioning) neutrophils can also serve as reservoir for pathogens that are able to survive inside the cellular environment. Staphylococcus aureus is a notorious facultative intracellular pathogen. Most vulnerable for neutrophil dysfunction and intracellular infection are immune-deficient patients or, as has recently been described, severely injured patients. These dysfunctional neutrophils can become hide-out spots or “Trojan horses” for S. aureus. This location offers protection to bacteria from most antibiotics and allows transportation of bacteria throughout the body inside moving neutrophils. When neutrophils die, these bacteria are released at different locations. In this review, we therefore focus on the capacity of several groups of antibiotics to enter human neutrophils, kill intracellular S. aureus and affect neutrophil function. We provide an overview of intracellular capacity of available antibiotics to aid in clinical decision making. In conclusion, quinolones, rifamycins and sulfamethoxazole-trimethoprim seem very effective against intracellular S. aureus in human neutrophils. Oxazolidinones, macrolides and lincosamides also exert intracellular antibiotic activity. Despite that the reviewed data are predominantly of in vitro origin, these findings should be taken into account when intracellular infection is suspected, as can be the case in severely injured patients.

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Section: Resultsmentioning

confidence: 99%

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

et al. 2019

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“…Les ROS sont extrêmement réactifs et peuvent modifier et altérer des molécules, autant de propriétés utilisées dans la défense antimicrobiennes. Les données concernant l'effet des macrolides à ce niveau sont également encore divergentes et sujettes à caution : certaines études retrouvent une augmentation de la production de ROS en présence de macrolides [50], alors que d'autres retrouvent une diminution [51,52]. Les différences observées sont peutêtre secondaires à des variations des conditions expérimentales.…”

Section: Effets Sur Les Polynucléaires Neutrophilesunclassified

Effets immunomodulateurs des macrolides au cours des pathologies respiratoires chroniques

et al. 2013

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“…Macrolides having 14‐ and, to a lesser extent, 15‐member rings display substantial anti‐inflammatory activity [18]. However, the anti‐inflammatory effect of the macrolide antibiotics with 16‐member rings such as josamycin [14,19] and spiramycin [20–22] is highly variable and controversial.…”

Section: Introductionmentioning

confidence: 99%

Macrolide antibiotics and pulmonary inflammation

Hoyt

Robbins

2001

FEMS Microbiology Letters

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Many clinically effective therapeutic agents can exhibit localized and systemic effects that are manifestly different from their intended primary pharmacological mode of action. Macrolide antibiotics such as erythromycin and its derivatives are no exception. In addition to their antibacterial action, this class of antibiotics exhibits anti-inflammatory activity in a variety of airway diseases such as asthma and diffuse panbronchiolitis that is separate and distinct from a direct antibacterial action. A variety of erythromycin derivatives have been shown to be clinically beneficial in these airway diseases. The anti-inflammatory activities of these macrolide antibiotics are becoming a research topic of intense interest. Recent work in this field has led to the understanding of the various physiological, cellular and molecular processes of the inflammatory response that are inhibited or suppressed by these compounds. This review presents a brief summary of the fascinating recent work in this active research area.

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In Vitro Interaction Between Spiramycin and Polymorphonuclear Neutrophils Oxidative Metabolism

Cited by 5 publications

References 0 publications

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

Effets immunomodulateurs des macrolides au cours des pathologies respiratoires chroniques

Macrolide antibiotics and pulmonary inflammation

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