In Vitro Investigation of Bioactive Glass-Ceramic Composites Based on Biogenic Hydroxyapatite or Synthetic Calcium Phosphates

Pinchuk, N. D.; Parkhomey, Oleksandr; Sych, Olena

doi:10.1186/s11671-017-1895-1

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…We have demonstrated, for the first time, that a biogenic hydroxyapatite can be directly biomineralized onto the surface of ordinary Portland cement and described the biochemical mechanisms behind this deposition process. Both XRD and FT-IR analyses illustrate that the disorder, carbonation, crystal structure, and crystallite size of this deposited hydroxyapatite are similar to those of natural apatite materials with associated advantages over synthetic apatites, which have been described elsewhere. ,− The direct biomineralization of hydroxyapatite on OPC has never been reported before, and as such, the biochemical mechanisms underlying this process have not been investigated to date.…”

Section: Discussionmentioning

confidence: 97%

“…The crystal structure of naturally occurring HAP is too complex to be accurately mimicked by synthetic crystalline apatites, and the use of synthetic apatites has been observed to result in poor adhesion and low mechanical strength in the field of dental treatments and reduced radionuclide sorption capacity in the field of environmental decontamination . Hydroxyapatite produced through the direct actions of a living organism (termed biogenic hydroxyapatite) may offer a solution to these limitations via intrinsic properties such as reduced solubility and comparable particle size to natural hydroxyapatites. − …”

Section: Introductionmentioning

confidence: 99%

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Biogenic Hydroxyapatite: A New Material for the Preservation and Restoration of the Built Environment

Turner

Renshaw

Hamilton

2017

ACS Appl. Mater. Interfaces

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Ordinary Portland cement (OPC) is by weight the world's most produced man-made material and is used in a variety of applications in environments ranging from buildings, to nuclear wasteforms, and within the human body. In this paper, we present for the first time the direct deposition of biogenic hydroxyapatite onto the surface of OPC in a synergistic process which uses the composition of the cement substrate. This hydroxyapatite is very similar to that found in nature, having a similar crystallite size, iron and carbonate substitution, and a semi-crystalline structure. Hydroxyapatites with such a structure are known to be mechanically stronger and more biocompatible than synthetic or biomimetic hydroxyapatites. The formation of this biogenic hydroxyapatite coating therefore has significance in a range of contexts. In medicine, hydroxyapatite coatings are linked to improved biocompatibility of ceramic implant materials. In the built environment, hydroxyapatite coatings have been proposed for the consolidation and protection of sculptural materials such as marble and limestone, with biogenic hydroxyapatites having reduced solubility compared to synthetic apatites. Hydroxyapatites have also been established as effective for the adsorption and remediation of environmental contaminants such as radionuclides and heavy metals. We identify that in addition to providing a biofilm scaffold for nucleation, the metabolic activity of Pseudomonas fluorescens increases the pH of the growth medium to a suitable level for hydroxyapatite formation. The generated ammonia reacts with phosphate in the growth medium, producing ammonium phosphates which are a precursor to the formation of hydroxyapatite under conditions of ambient temperature and pressure. Subsequently, this biogenic deposition process takes place in a simple reaction system under mild chemical conditions and is cheap and easy to apply to fragile biological or architectural surfaces.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Biogenic Hydroxyapatite: A New Material for the Preservation and Restoration of the Built Environment

Turner

Renshaw

Hamilton

2017

ACS Appl. Mater. Interfaces

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“…Calcium hydroxyapatite, resulting from the direct action of a living organism, so-called "biogenic" hydroxyapatites, provides a possibility to overcome the limitations of synthetic apatites, including poor adhesion and low mechanical strength. In fact, calcium hydroxyapatite possesses very useful properties such as reduced solubility and convenient particle size (30).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Nano-Crystal Hydroxyapatites on the Regeneration of Bone Defects

Issabayev

Fazylov

Temirbayev

et al. 2021

Serbian Journal of Experimental and Clinical Research

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Calcium hydroxyapatite is a widely used material for replacing bone defects. However, the effectiveness of nano-crystalline calcium hydroxyapatite produced from eggshells in the replacement of bone defects has not been investigated yet. The study aimed to evaluate the effectiveness of using nano-crystalline calcium hydroxyapatite made from eggshell for the healing of bone defect of the femur in rats. Forty-eight (n=48) rats underwent a surgical procedure to simulate femoral defect. The animals were sub-divided into 4 groups (each with n=12) depending on the methods of bone defect replacement: I control group (CG) (without bone defect replacement); II intervention group (the bone defect was replaced by PRP (PRP); III intervention group (the bone defect was replaced by nano-crystalline hydroxyapatite obtained from eggshell) (HA) and IV interventional group (the bone defect was replaced by a combination of hydroxyapatite and PRP) (HA+PRP). The degree of effectiveness of studied methods was assessed using radiological (on the 14th day), histological (on the 61st day), and biomechanical analysis (on the 61st day). According to radiographic data, the CG group had the lowest level of bone regeneration after 14 days (4.2 ±1.7%). In the HA + PRP group, the level of bone regeneration was 22.1±7.1 %, which was higher in comparison with the rates of consolidation of bone defects in the HA group (20.7± 9.3) (p = 0.023). According to the histo-morphometry data, the rates of bone tissue regeneration in the PRP group (19.8 ±4.2%) were higher in comparison with the CG group (12.7 ± 7.3%), (p>0.05). In the HA+PRP group, bone regeneration rates (48.9±9.4 %) were significantly higher (p=0.001) than in the HA group (35.1±9.8%). According to the results of biomechanical assessment under the maximum stress (121.0722), the maximum bending deformation of the contralateral bone without defect was 0.028746, which was higher than the indicators of the HA+PRP group, where at the maximum stress (90.67979) the bending deformation was 0.024953 (p>0.05). Compared to CG, PRP, and HA, biomechanical bone strength was significantly higher in the HA + PRP group (p≤0.01). At the maximum stress (51.81391), the maximum bending strain in the CG group was 0.03869, which was lower than in the PRP group, where the maximum stress and bending strain were 59.45824 and 0.055171, respectively (p>0.05). However, the bone strength of the HA group was statistically significantly higher compared to the CG and PRP groups (p<0.01). The results demonstrated the effectiveness of the use of nanocrystalline calcium hydroxyapatite obtained from eggshell in the healing of a bone defect. The best results were observed in the group of the combined use of nano-crystalline calcium hydroxyapatite and PRP.

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“…The mass fraction of any phase is considered zero if its value is below the detection threshold [44].…”

Section: Methodsmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.

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In Vitro Investigation of Bioactive Glass-Ceramic Composites Based on Biogenic Hydroxyapatite or Synthetic Calcium Phosphates

Cited by 9 publications

References 21 publications

Biogenic Hydroxyapatite: A New Material for the Preservation and Restoration of the Built Environment

Biogenic Hydroxyapatite: A New Material for the Preservation and Restoration of the Built Environment

The Impact of Nano-Crystal Hydroxyapatites on the Regeneration of Bone Defects

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

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