In vitro Investigation of Cytotoxic and Apoptotic Effects of Cynara L. Species in Colorectal Cancer Cells

Şimşek, E.; Uysal, Tuna

doi:10.7314/apjcp.2013.14.11.6791

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…Here we investigated whether, a phytocomplex derived from Artichoke leaves extracts, affects malignancy of pleural mesothelioma. It has been previously reported that artichoke phenol extracts can promote apoptosis and impair invasiveness of different cancer cell lines [ 34 – 36 ]. We found that the artichoke extract exerts in vitro and in vivo a broad anti-tumoral effect by strongly affecting MPM growth, migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Several in vitro and in vivo experiments have shown that Cynara scolymus exhibits choleretic, hepatoprotective, antibacterial, antinflammatory, antithrombotic and hypocolesterolemic properties [ 30 ] [ 31 ] [ 32 ] [ 33 ]. Artichoke extracts are reported to induce apoptosis and cytotoxic effects in cancer cells [ 34 ] [ 35 ] [ 36 ]. In the present report we aimed to demonstrate the anti-cancer activity of the artichoke leaf extract through direct experimental tests, through the normalizing effect of the extract on the cancer metabolic alterations and through the evidence of extract antitumoral activity due to its impact on signalling pathways of oncogenic significance.…”

Section: Introductionmentioning

confidence: 99%

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Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Pulito¹,

Mori²,

Sacconi³

et al. 2015

Oncotarget

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Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Pulito¹,

Mori²,

Sacconi³

et al. 2015

Oncotarget

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“…Furthermore, the pro-apoptotic (BAX) gene expression and a cell cycle inhibitor (p21) were induced, while the anti-apoptotic BCL-2 gene expression was reduced in the extract's presence. However, a BAX/BCL-2 ratio increment was detected, which implied that the Cynarae flos extract had the ability to induce the intrinsic apoptotic pathway (68). Additionally, the phytochemical composition, which includes polyphenolic compounds, inhibits angiogenesis related to cancer (69).…”

Section: Cytotoxic Activity Of the Selected Herbal Extractsmentioning

confidence: 99%

Evaluation Of Potential Cytotoxic Effects Of Herbal Extracts

Radovanović¹

2015

Serbian Journal of Experimental and Clinical Research

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Herbal medicines have played an important role in treating different diseases since ancient times. Bioactive components of medicinal plants are a good starting point for discovering new drugs such as chemotherapeutics. Currently, there are four classes of plant-derived chemotherapeutic drugs used in clinical practice. However, to discover new potential cytotoxic molecules, the research effort on herbal extracts has not diminished. The aim of this review was to evaluate the chemical constituents of plants that possess cytotoxicity, the signalling pathways responsible for this effect, and the influence of solvent polarity on potential cytotoxic effect and to present the cytotoxic activity of selected herbal extracts. The polyphenolic, anthraquinon, diterpneoid, triterpenoid, flavonoid, betulinic acid and berberine content contributes to cytotoxicity of herbal extracts. The inhibitory effect on cancer cells viability could be a consequence of the non-apoptotic processes, such as cell cycle arrestment, and the apoptotic process in tumour cells through different signalling pathways. The influence of solvent polarity on potential cytotoxic effect of herbal extracts should not be ignored. In general, the best cytotoxic activity was found in nonpolar and moderately polar herbal extracts. The herbal extract with IC50 below 30 μg/ml could be considered a very strong cytotoxic agent. Considering that many antitumor drugs have been discovered from natural products, further research on plants and plant-derived chemicals may result in the discovery of potent anticancer agents.

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“…Artichoke polyphenolic extracts had cytotoxic and apoptotic effects on colorectal cancer cells. It has been found that the proapoptotic BAX gene expression and a cell cycle inhibitor p21 CIP/WAF1 were induced in the presence of artichoke polyphenols [ 117 ]. Polyphenolic extracts from the edible part of artichoke (AEs) exhibited cancer cytotoxic activity on a human hepatoma cell line [ 118 ] as well as on other cell lines derived from various human tissues.…”

Section: Advances and Novelty In Cancer Chemoprevention And Treatmmentioning

confidence: 99%

Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

Mileo¹,

Miccadei²

2015

Oxidative Medicine and Cellular Longevity

219

130

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Cancer onset and progression have been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation and therefore antioxidant agents could interfere with carcinogenesis. It is well known that conventional radio-/chemotherapies influence tumour outcome through ROS modulation. Since these antitumour treatments have important side effects, the challenge is to develop new anticancer therapeutic strategies more effective and less toxic for patients. To this purpose, many natural polyphenols have emerged as very promising anticancer bioactive compounds. Beside their well-known antioxidant activities, several polyphenols target epigenetic processes involved in cancer development through the modulation of oxidative stress. An alternative strategy to the cytotoxic treatment is an approach leading to cytostasis through the induction of therapy-induced senescence. Many anticancer polyphenols cause cellular growth arrest through the induction of a ROS-dependent premature senescence and are considered promising antitumour therapeutic tools. Furthermore, one of the most innovative and interesting topics is the evaluation of efficacy of prooxidant therapies on cancer stem cells (CSCs). Several ROS inducers-polyphenols can impact CSCs metabolisms and self-renewal related pathways. Natural polyphenol roles, mainly in chemoprevention and cancer therapies, are described and discussed in the light of the current literature data.

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In vitro Investigation of Cytotoxic and Apoptotic Effects of Cynara L. Species in Colorectal Cancer Cells

Cited by 23 publications

References 23 publications

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Evaluation Of Potential Cytotoxic Effects Of Herbal Extracts

Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

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