In-vitro Investigation of the Anticancer Efficacy of Carboplatin-Loaded Chitosan Nanocomposites Against Breast and Liver Cancer Cell Lines

Ramadan, Ibrahim; Nassar, Mostafa Y.; Gomaa, Aya

doi:10.1007/s10924-022-02668-y

Cited by 21 publications

(7 citation statements)

References 57 publications

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“…The DRE, where given, was found to be quite high, on average, for all CNMs, with NDs displaying the lowest values; however, the sample size for this material was small compared to those for graphene and CNTs. Graphene-based nanocarriers incorporating Fe 3 O 4 showed particularly high loading and release: [ 47 , 85 , 193 ]. GO-COOH also displayed high loading and release properties [ 133 ].…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

2023

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Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to design effective anticancer systems. This article is the first comprehensive review of CNM-based nanocarrier systems that incorporate approved chemotherapy drugs, and many different types of CNMs and chemotherapy agents are discussed. Almost 200 examples of these nanocarrier systems have been analysed and compiled into a database. The entries are organised by anticancer drug type, and the composition, drug loading/release metrics, and experimental results from these systems have been compiled. Our analysis reveals graphene, and particularly graphene oxide (GO), as the most frequently employed CNM, with carbon nanotubes and carbon dots following in popularity. Moreover, the database encompasses various chemotherapeutic agents, with antimicrotubule agents being the most common payload due to their compatibility with CNM surfaces. The benefits of the identified systems are discussed, and the factors affecting their efficacy are detailed.

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Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

2023

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“…The complexes are linked to the DNA, resulting in double-strand breaks. Magnetite-chitosan (CS-Fe 3 O 4 ) and magnetite-chitosan-graphene oxide (CS-Fe 3 O 4 -GO) nanocomposites were used for loading and targeted delivery of carboplatin to breast cancer cell lines [59]. The entrapment of the drug in magnetite-based systems reduced the systemic toxicity of carboplatin and enhanced its activity against MCF-7 cell lines.…”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery

Kurczewska,

Dobosz

2024

Applied Sciences

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Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over the years, the ability to synthesize diverse systems based on iron (II, III) oxide nanoparticles has been mastered to maximize their potential effectiveness in the targeted delivery of active substances in cancer therapy. The present review explores recent literature findings that detail various magnetic nanosystems. These encompass straightforward designs featuring a polymer coating on the magnetic core and more intricate matrices for delivering chemotherapeutic drugs. This paper emphasizes novel synthetic approaches that impact the efficacy and progress of anticancer investigations, specifically targeting a particular cancer type. The research also delves into combinations with alternative treatment methods and diagnostic approaches. Additionally, it highlights a critical aspect—the interaction with cells—identifying it as the least developed aspect in current research on these systems.

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“…CBP is known for its systemic side effects such as myelosupression, nephrotoxicity, ototoxicity, cardiotoxicity, and peripheral neurotoxicity [10]. The onset of these side effects could be postponed or eliminated by the encapsulation of CBP in drug delivery systems such as PEGylated niosomes [11], bovine serum albumin nanoparticles [12], gelatin nanoparticles [13], chitosan nanoparticles [14], graphitic carbon nitride [15], or polymer-functionalized metal-organic frameworks [16].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensing Device for Carboplatin Monitoring in Proof-of-Concept Drug Delivery Nanosystems

Pusta,

Tertis,

Ardusadan

et al. 2024

Nanomaterials

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(1) Background: Carboplatin (CBP) is a chemotherapeutic drug widely used in the treatment of a variety of cancers. Despite its efficiency, CBP is associated with side effects that greatly limit its clinical use. To mitigate these effects, CBP can be encapsulated in targeted delivery systems, such as liposomes. Ensuring the adequate loading and release of CBP from these carriers requires strict control in pharmaceutical formulation development, demanding modern, rapid, and robust analytical methods. The aim of this study was the development of a sensor for the fast and accurate quantification of CBP and its application on proof-of-concept CBP-loaded nanosomes. (2) Methods: Screen-printed electrodes were obtained in-lab and the electrochemical behavior of CBP was tested on the obtained electrodes. (3) Results: The in-lab screen-printed electrodes demonstrated superior properties compared to commercial ones. The novel sensors demonstrated accurate detection of CBP on a dynamic range from 5 to 500 μg/mL (13.5–1350 μM). The method was successfully applied on CBP loaded and released from nanosomes, with strong correlations with a spectrophotometric method used as control. (4) Conclusions: This study demonstrates the viability of electrochemical techniques as alternative options during the initial phases of pharmaceutical formulation development.

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In-vitro Investigation of the Anticancer Efficacy of Carboplatin-Loaded Chitosan Nanocomposites Against Breast and Liver Cancer Cell Lines

Cited by 21 publications

References 57 publications

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery

Electrochemical Sensing Device for Carboplatin Monitoring in Proof-of-Concept Drug Delivery Nanosystems

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