In vitro investigation on probiotic, anti-Candida, and antibiofilm properties of Lactobacillus pentosus strain LAP1

Aarti, Chirom; Khusro, Ameer; Varghese, Rakesh; Arasu, Mariadhas Valan; Agastian, Paul; Al-Dhabi, Naïf Abdullah; Ilavenil, Soundharrajan; Choi, Ki Choon

doi:10.1016/j.archoralbio.2018.02.014

Cited by 54 publications

(30 citation statements)

References 46 publications

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“…Taken together, lactic acid is most probably not the sole antifungal agent produced by Lactobacillus spp. Neutralized supernatants of L. pentosus [123,124], L. rhamnosus GR-1 and L. reuteri RC-14 [11] were able to inhibit growth of C. albicans [123,124] and C. glabrata [11]. In support of this, inhibition of Candida spp.…”

Section: Lactic Acidmentioning

confidence: 67%

“…Therefore, competition for binding sites could be partly influencing proper adhesion of Candida to mucosal surfaces [12]. With regard to studies with NAC species, L. reuteri [12], L. pentosus [123] L. rhamnosus GR-1 and L. reuteri RC-14 [11] were shown to possess the ability to co-aggregate with various Candida species besides C. albicans, for example C. glabrata [11,12], C. krusei [12] or C. tropicalis [123]. Interestingly, good initial adhesion of L. gasseri, L. crispatus or L. vaginalis isolates was not consistent with good inhibition of adherence of C. albicans [125].…”

Section: Other Antifungal Factorsmentioning

confidence: 99%

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The role of Lactobacillus species in the control of Candida via biotrophic interactions

et al. 2020

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Microbial communities have an important role in health and disease. Candida spp. are ubiquitous commensals and sometimes opportunistic fungal pathogens of humans, colonizing mucosal surfaces of the genital, urinary, respiratory and gastrointestinal tracts and the oral cavity. They mainly cause local mucosal infections in immune competent individuals. However, in the case of an ineffective immune defense, Candida infections may become a serious threat. Lactobacillus spp. are part of the human microbiome and are natural competitors of Candida in the vaginal environment. Lactic acid, low pH and other secreted metabolites are environmental signals sensed by fungal species present in the microbiome. This review briefly discusses the ternary interaction between host, Lactobacillus species and Candida with regard to fungal infections and the potential antifungal and fungistatic effect of Lactobacillus species. Our understanding of these interactions is incomplete due to the variability of the involved species and isolates and the complexity of the human host.

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Section: Lactic Acidmentioning

confidence: 67%

Section: Other Antifungal Factorsmentioning

confidence: 99%

The role of Lactobacillus species in the control of Candida via biotrophic interactions

et al. 2020

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“…to inhibit the adherence of Candida on the host tissues have been directly correlated with the cell surface hydrophobicity of lactobacilli since these characteristics directly influence its adhesion to the epithelial tissue, forming a mechanical barrier against Candida adhesion (Kang et al 2018;Santos et al 2019). Aarti et al (2018) verified that L. pentosus strain LAP1, isolated from Hentak (a fermented fish of Manipur, India) had a significant level of auto-aggregation and hydrophobicity percentage, as well as a relevant antifungal activity against C. albicans, C. tropicalis and C. krusei. These characteristics make this strain a possible candidate for biotherapeutic products against Candida infections.…”

Section: Inhibition Of Adherence and Antimicrobial Activitymentioning

confidence: 69%

Action mechanisms of probiotics onCandidaspp. and candidiasis prevention: an update

et al. 2019

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Due to the high incidence of fungal infections caused by Candida species and their increasing resistance to antimicrobial treatments, alternative therapies such as probiotics have been studied. It has been show that several species of the genus Lactobacillus have anti-Candida activity, probably by direct inhibition, through competition for adhesion sites or production of secondary metabolites, and by indirect inhibition, through stimulation of the immune system of their host. However, the mechanisms of inhibition of these probiotics on Candida species have not yet been fully elucidated since this effect is related to more than one inhibition pathway. In the literature, several in vitro and in vivo studies have been developed seeking to elucidate the probiotics mechanisms of action. These studies have been focused on C. albicans inhibition assays, including analysis of antimicrobial activity, adherence capacity, biofilms formation, filamentation and interference on virulence genes, as well as assays of experimental candidiasis in invertebrate and vertebrate models. In this context, the purpose of this review was to gather different studies focused on the action mechanism of probiotic strains on Candida sp. and to discuss their impact on the candidiasis prevention.

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“…García-Cayuela et al (2009) reported that beneficial bacteria, mainly LAB and bifidobacteria, could be a useful and effective strategy for preventing or reducing the incidence of pathogens, thereby improving food safety and protecting consumer health. LAB producing antimicrobial agents have been used as an alternative to antibiotics for the treatment of gastrointestinal diseases (Soomro et al, 2002;Akpinar et al, 2011) and against infections by Candida (Aarti et al, 2018).…”

Section: Antibacterial Activity Against Pathogenic Strainsmentioning

confidence: 99%

“…To be designated as such they must meet several criteria mainly resistance to gastric and intestinal conditions, résistance to antibiotics, antagonism against pathogens, adhesion to intestinal epithelial cells and safety (Salminen et al, 1998;Aarti et al, 2017). The pharmaceutical or agri-food industries are increasingly using probiotics as a dietary supplement (Liao and Nyachoti, 2017), as additives or as alternatives to antimicrobials (Aarti et al, 2018;Alagawany et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Selection of Lactobacillus strains newly isolated from Algerian camel and mare fermented milk for their in vitro probiotic and lipolytic potentials

Amara¹,

Zadi‐Karam²,

Karam³

2019

Afr. J. Biotechnol.

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The main objective of this study was the characterization of new lactobacilli probiotic strains belonging to lactic acid bacteria (LAB). Eighty-eight strains were isolated from different Algerian camel and mare fermented milks; three of them were pre-selected for their stability, fast growth and resistance to acidity and bile salts. Cell viability was assessed in simulated gastric and intestinal conditions. On the other hand, cell safety was checked by testing their hemolytic capacity. The in vitro tests revealed a good probiotic potential of selected strains. The majority of lactobacilli is resistant to cross-stress and persists beyond 4 h of incubation in contact with simulated gastrointestinal juices; a survival rate of over 80% was observed. All strains showed better lipolytic activity in the presence of natural substrates compared to Tween-80. Lipolysis zones diameters obtained in the presence of butter and olive oil were remarkable (between 20 and 27 mm respectively). Investigation of the cholesterol-lowering and the triglyceride-lowering properties revealed a cholesterol ratio degradation of 54.8% and a triglyceride ratio degradation of 80.3% for Lactobacillus plantarum NSC5C.

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In vitro investigation on probiotic, anti-Candida, and antibiofilm properties of Lactobacillus pentosus strain LAP1

Cited by 54 publications

References 46 publications

The role of Lactobacillus species in the control of Candida via biotrophic interactions

The role of Lactobacillus species in the control of Candida via biotrophic interactions

Action mechanisms of probiotics onCandidaspp. and candidiasis prevention: an update

Selection of Lactobacillus strains newly isolated from Algerian camel and mare fermented milk for their in vitro probiotic and lipolytic potentials

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