2005
DOI: 10.1159/000084840
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In vitro Isolation and Cell Culture of Vestibular Inner Ear Melanocytes

Abstract: Introduction: Melanocytes of the membranous labyrinth of the inner ear have been described morphologically in various contexts. Nature and functions of these cells are as yet not completely clear, even though several hypotheses exist regarding the same. The limited knowledge is due in part to a lack of methods regarding in vitro cell culture. The aim of this study was to describe conditions for the successful cell culture of vestibular inner ear melanocytes (VIEM), to compare their growth properties with those… Show more

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Cited by 8 publications
(4 citation statements)
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“…Variable pigmentation intensities were also previously reported in cultured primary human melanocytes (Hanke et al 2005). The level of pigmentation was not as intense as in the excised tissue, and this can be attributed to the fact that melanoma cell cultures may rapidly alter mRNA and protein expression due to a lack of cell-cell interactions as previously indicated (Hofbauer et al 2001).…”
Section: Discussionsupporting
confidence: 54%
“…Variable pigmentation intensities were also previously reported in cultured primary human melanocytes (Hanke et al 2005). The level of pigmentation was not as intense as in the excised tissue, and this can be attributed to the fact that melanoma cell cultures may rapidly alter mRNA and protein expression due to a lack of cell-cell interactions as previously indicated (Hofbauer et al 2001).…”
Section: Discussionsupporting
confidence: 54%
“…Melanocytes, however, are not restricted to the skin and can be found in the inner ear and the leptomeninges (5,6). The persistence of melanocytes in these non‐sun‐exposed organs throughout evolution suggests that melanocytes might have a role other than protection from sun radiation.…”
Section: Commentary #2mentioning
confidence: 99%
“…The mechanotransduction function of these sensory cells is crucially dependent on the unusual K + -enriched ionic composition of endolymph, on which cochlear melanocytes (also called intermediate cells) of the stria vascularis are known to play a key role (Tachibana, 1999; Zdebik et al, 2009). Although the similar distribution of melanocytes around the utricle and ampullae has been described a long time ago in both human and rodents (Escobar et al, 1995; LaFerriere et al, 1974; Masuda et al, 1995), the function of such vestibular melanocytes remains currently unclear (Barozzi et al, 2015; Masuda et al, 2001; Sanchez Hanke et al, 2005). …”
Section: Introductionmentioning
confidence: 95%