In vitro leucocyte adhesion to modified polyurethane surfaces

Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

“…S1 in the Supplementary Data). The increase of adhesion of healthy leukocytes with the decrease of surface hydrophobicity is in agreement with the literature [6,7,28,46]. Our results were also in agreement with a previous study where adhesion performance of L1210 cells to the sulfonated PS surface was higher than that of non-sulfonated ones [27].…”

“…It was also determined that adhesion of L1210 cells increased linearly with the increase of the sulfo group ( SO 3 H) concentration on sulfonated PS surfaces [27]. Adhesion properties of human leukocytes to surfaces were also investigated previously and it was found that the number of leukocytes which adhered to the polymeric surfaces modified by surface sulfonation or addition of other functional groups was higher than the non-modified surfaces [28]. The activation of adherent leukocytes was found to be dependent on surface topography, pattern geometry and surface chemistry of the substrate [18].…”

Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

“…Previous studies, which employed leukocyte suspensions, have shown that surface modification with PEI of polyurethane films/filters improved leukocyte removal and adhesion to surfaces; however, no improvement was found when whole blood was used [51,52]. Leukocytes have a negative zeta potential [53] and therefore are prone to interact strongly with the positive surface of the NiNW.…”

“…Leukocytes have a negative zeta potential [53] and therefore are prone to interact strongly with the positive surface of the NiNW. However, other types of interactions are certainly involved, such as hydrogen bonding between groups on the leukocyte membrane and electronegative nitrogen atoms of PEI [52][53][54]. Moreover, it has been widely accepted that surface wettability and hydrophilicity also influence the adhesion of leukocytes [53,54].…”

Professor Jan Feijen: A pioneer in biomedical polymers and controlled drug release

“…He has developed various surface modification techniques including wet chemical modifications and gas-plasma treatments [42,43]. The results showed that pre-adsorption of albuminheparin conjugates could effectively inhibit surface-induced coagulation [44], the wettability of polymeric surfaces played an important role in their interactions with human endothelial cells [45,46], and the leukocyte adhesion to modified polyurethane surfaces was affected by their ionizable functional groups [47,48].…”