In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients

Trounson, Alan; Wood, Carl; Kausche, Annette

doi:10.1016/s0015-0282(16)56891-5

Cited by 534 publications

(313 citation statements)

References 21 publications

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“…Many IVM studies have been performed in different mammalian species such as pigs and cattle [1]; this technique is used for the commercial production of laboratory animal embryos such as rats and mice [2]. Although this technique is successful in animals, in human there has been less success [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although this technique is successful in animals, in human there has been less success [3]. Females diagnosed with disorders such as ovarian failure and polycystic ovarian syndrome (PCOS) have a low ovarian stimulation response and the use of reproductive technologies for such disorders or for in vitro maturation of immature oocytes causes problem with the maturation of oocytes in addition to decreasing their developmental competence [2,4]. Therefore, improving IVM protocols by adding different hormones, growth factors [5], and vitamins [6,7] is necessary in order to increase medium efficiency to support the competence of immature oocytes for fertilization and embryogenesis [8].…”

Section: Introductionmentioning

confidence: 99%

“…According to Alminana, the use of RA in the maturation process increased embryo development in porcine oocytes [13]. On the other hand, studies have shown the usefulness of the co-culture with a monolayer of various somatic cell types on both in vitro oocyte maturation and mammalian embryonic development [2,[14][15][16][17]. Different types of somatic cells have been routinely used for co-culture systems including oviduct and uterine cells, fetal bovine uterine fibroblasts, African green monkey kidney epithelial cells (Vero cells) [17,18] and granulosa cells [19].…”

Section: Introductionmentioning

confidence: 99%

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Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system

Tahaei

Eimani

Eftekhari‐Yazdi

et al. 2011

J Assist Reprod Genet

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Purpose Evaluation of the all-trans retinoic acid (t-RA) effects on in vitro maturation (IVM) and in vitro fertilization (IVF) of immature mouse oocytes in the presence and absence of granulosa cell monolayer. Methods Denuded oocytes isolated from mice ovaries and matured in IVM medium alone (Control I), IVM medium in the presence of granulosa cells (Control II), IVM medium with t-RA (Experimental I) and IVM medium simultaneously with t-RA and granulosa cells (Experimental II). After 24 h, matured oocytes were fertilized in T6 medium and their development was followed until the blastocyst stage. Metaphase II oocytes ploidy were evaluated by chromosome counting. Results The t-RA group compared to the control groups showed no obvious abnormalities. Additionally maturation and embryo development rates significantly increased in the t-RA treated granulosa cell co-culture system. Conclusions In conclusion, association of t-RA with granulosa cell co-culture during in vitro maturation increases meiosis resumption, formation of metaphase II oocytes, as well as 2-cell and blastocyst stage embryos.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system

Tahaei

Eimani

Eftekhari‐Yazdi

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…There are several important reasons for the clinical application of oocyte IVM. First, the routine hormonal stimulation protocols used for induction of ovulation in human IVF are not suitable for some infertile patients at risk of ovarian hyperstimulation syndrome (e.g., women suffering from polycystic ovarian syndrome; Trounson et al, 1994;Russell, 1998). The IVM of oocytes from unstimulated or mildly stimulated follicles of these patients is an attractive alternative to hormone stimulation (Chian et al, 2004a, b, c).…”

Section: Introductionmentioning

confidence: 99%

Effects of in vitro maturation of monkey oocytes on their developmental capacity

Zheng

2007

Animal Reproduction Science

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The study of in vitro maturation (IVM) of rhesus monkey oocytes has important implications for biomedical research and human infertility treatment. In vitro-matured rhesus monkey oocytes show much less developmental potential than IVM oocytes of other species. Since about 1980 when rhesus monkey IVM, in vitro fertilization (IVF) and in vitro embryo culture (IVC) systems were established, numerous efforts have been made to improve the developmental competence of oocytes and to understand the mechanisms regulating oocyte maturation. This review describes recent progress in this area, particularly the effects of factors such as steroid hormones, energy substrates, amino acids, ovarian follicle status, maternal age and breeding season on the developmental competence, gene expression patterns and genome integrity of rhesus IVM oocytes.

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“…The only way to prevent OHSS reliably would be to avoid stimulating the ovaries. Because stimulated ovaries are not necessary for treatment by in vitro maturation (IVM) of immature oocytes, this technique has received increased attention in recent years (2,3).…”

Section: Introductionmentioning

confidence: 99%

Endometrial preparation for in vitro oocyte maturation: Early use of estrogen increases endometrial tissue and requires lower daily dosage: A cross over trial in ‘mock’ cycles

Martins

Reis

Ferriani

et al. 2006

J Assist Reprod Genet

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Purpose: Determine if estrogen used since the beginning of the menstrual flow could improve endometrial tissue compared to standard endometrial preparation for in vitro maturation cycles.Methods: Twenty polycystic ovary syndrome women were submitted to two estrogen therapy schedules: standard schedule; estrogen began on the day of planned egg retrieval (dosage was based on endometrial thickness); and long schedule; estrogen began on the first day of menstruation. No oocyte retrieval or embryo transfer was performed. Three-dimensional ultrasound was performed on the day of planned egg retrieval and one week later for endometrial evaluation.Results: A higher endometrial thickness and volume was found in long schedule on both evaluations. The number of patients that have used 10 mg/day of estradiol was significant higher in the standard schedule (65% × 0%). No other significant difference was found.Conclusions: The early use of estrogen improves endometrial tissue and requires lower daily dosage.

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In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients

Cited by 534 publications

References 21 publications

Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system

Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system

Effects of in vitro maturation of monkey oocytes on their developmental capacity

Endometrial preparation for in vitro oocyte maturation: Early use of estrogen increases endometrial tissue and requires lower daily dosage: A cross over trial in ‘mock’ cycles

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