In vitro maturation may prevent the cancellation of in vitro fertilization cycles in poor responder patients: A case report

Yalçınkaya, Ender; Çalışkan, Eray; Budak, Özcan

doi:10.5152/jtgga.2013.68335

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Jaroudi et al ( 22 ) were the first to report 3 cases in which IVM was used to secure cycles in poor responders, which resulted in deliveries of healthy babies. In a case report from Turkey, Yalcınkaya et al ( 23 ) studied IVM in a poor responder patient who achieved pregnancy and concluded that IVM could be used in poor responders as a good alternative. Braga et al ( 24 ) from Brazil used IVM to mature immature oocytes derived from stimulated cycles but they found that rescue spontaneous maturation of the oocytes did not contribute to clinical pregnancy rates in poor responder women.…”

Section: Discussionmentioning

confidence: 99%

The use of in vitro maturation in stimulated antagonist in vitro fertilization cycles of normo-hyperresponder women due to arrested follicular development: A rescue procedure

Hatırnaz¹,

Akarsu

Hatırnaz³

et al. 2018

tjod

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Objective: To evaluate the impact of rescue in vitro maturation (IVM) on the clinical outcomes of women with arrested follicular development in stimulated in vitro fertilization (IVF) cycles.Materials and Methods:This is a retrospective review of 13 patients who were evaluated as normo-hyperresponders for ovarian stimulation. The main outcome measure was the clinical pregnancy and livebirth rates. The purpose of gonadotropin stimulation in patients undergoing IVF is to retrieve multiple oocytes by avoiding multifetal gestation and Ovarian Hyperstimulation syndrome (OHSS). The ovarian response to stimulation ranges from poor response to OHSS, which is related to the follicular number and the dose of the gonadotropins used. However, in some cycles of normo-hyperresponder women, follicular development decelerates or ceases. Close follow-up in a daily manner and increasing the dose of gonadotropins did not change the follicular arrest. This clinical situation has two edges; one is cycle cancellation, which has undesired psychological outcomes for women and the IVF team, and second one is the prolongation of the IVF cycle. For such circumstances, IVM may be a valuable option. Stimulated IVF cycles were converted to IVM as a rescue IVM procedure following detailed informed consent of the women who were close to cycle cancellation.Results:Thirteen 13 IVM cycles and their clinical outcomes are presented. Six women achieved pregnancies, but only 4 delivered 5 healthy live born. The other two women had biochemical loss during follow-up.Conclusion:Based on the data obtained, it can be concluded that gonadotropin-stimulated cycles with follicular arrest at the edge of cancellation can be shifted to rescue IVM procedures with reasonable clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

The use of in vitro maturation in stimulated antagonist in vitro fertilization cycles of normo-hyperresponder women due to arrested follicular development: A rescue procedure

Hatırnaz¹,

Akarsu

Hatırnaz³

et al. 2018

tjod

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“…Currently, there is a lack of perfect treatment for this group of patients, and most of their IVF cycles had to stop prematurely. In vitro maturation (IVM) is a fertility treatment option for poor responding PCOS patients to controlled ovarian stimulation (COS) [6,7]. However, the IVM procedure has various limitations and clinical concerns, including lower success rate of implantation, pregnancy, and live birth as well as a higher rate of aneuploidy and miscarriage [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary syndrome during IVF treatment: a pilot study

Zhou

Cheng

et al. 2020

Reprod Biol Endocrinol

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Background: Poor response patients with PCOS who are not susceptible to gonadotropin stimulation are more likely to have canceled cycles or poor clinical outcomes during IVF treatment. However, some limitations exist in the present therapies. In this study, we evaluated the effects of using the transvaginal ovarian drilling (TVOD) followed by controlled ovarian stimulation (COS) from the second day of these poor responders. Methods: During IVF, 7 poor responders with PCOS and 28 PCOS patients (14 normal and 14 high responders) were recruited. All patients received COS with the gonadotropin-releasing hormone antagonist protocol. For the poor responders, after undergoing 10 to 14 days of ovulation induction with no response, the TVOD was applied and then ovarian stimulation was performed from the next day at the same gonadotropin dose. Serum samples during COS and follicular fluid samples from the dominant follicles on the oocyte pickup (OPU) day in all three groups were collected. Besides, follicular fluid from small follicles (diameter < 1 cm) in the normal and high responders on the OPU day and those in the poor responders on the TVOD day were gathered. Hormonal levels were examined in all samples using immunometric assays. Results: All the poor responders restored ovary response after receiving TVOD. There was no significant difference in the stimulation duration, total gonadotrophin dose used and the clinical outcomes among the three groups. The body mass index, serum and follicular levels of anti-Müllerian hormone (AMH) and testosterone in poor responders were higher than those in the other two groups, and the application of TVOD significantly decreased the levels of AMH and testosterone in both serum and follicular fluid.

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“…Rescue in vitro maturation (IVM) is currently not a routine procedure in association with in vitro fertilization (IVF). Mehrdad Mir Farsi and colleagues' study has shown that 46% of the GV oocytes obtained from the stimulated cycles are matured, and about 25% of them are meiosis-associated anomalies (4).…”

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confidence: 99%

Does the Apoptosis Value of Cumulus Cells Play a Role in Rescue Oocyte in Vitro Maturation?

İrez

Dogan

Ciraci

et al. 2020

Gynecol Obstet Reprod Med

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OBJECTIVE: In this study, we aimed to investigate the role of the cumulus cell’s apoptosis parameter in the maturation of immature rescue oocytes. STUDY DESIGN: In this experimental study, donated immature germinal vesicle oocytes were cultured for, in vitro maturation, embryo development in matured germinal vesicle oocytes were compared with apoptotic properties of cumulus cells. RESULTS: In all of the immature oocytes after oocyte in vitro maturation, the maturation rate has been observed as 56.1% and 2PN rate as 63.0%. Afterin vitro maturation of germinal vesicle oocytes, there was no difference in apoptosis rates of the cumulus cells between mature and immature oocytes (p> 0.05). The ratio of 2PN in matured germinal vesicle oocytes showing embryo development was 35.4%. A positive correlation was found between luteinizing hormone values on day 3 and E2 values during HCG days during oocyte maturation and embryo development (p=0.021, p=0.020). In addition, it has been observed that the germinal vesicle oocytes, which have completed their maturation and developed into embryos, have high E2 values during HCG days (p=0.020).CONCLUSION: In our study, it has been demonstrated that in vitro maturation in rescue oocytes from stimulated cycles, embryo development potential could not be explained by the apoptosis parameter.

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In vitro maturation may prevent the cancellation of in vitro fertilization cycles in poor responder patients: A case report

Cited by 6 publications

References 13 publications

The use of in vitro maturation in stimulated antagonist in vitro fertilization cycles of normo-hyperresponder women due to arrested follicular development: A rescue procedure

The use of in vitro maturation in stimulated antagonist in vitro fertilization cycles of normo-hyperresponder women due to arrested follicular development: A rescue procedure

Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary syndrome during IVF treatment: a pilot study

Does the Apoptosis Value of Cumulus Cells Play a Role in Rescue Oocyte in Vitro Maturation?

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