In vitro Mechanistic Assays of Tetracyclic Iridoid Compounds Isolated from Morinda lucida Benth in Leishmania species

Azerigyik, Faustus Akankperiwen; Amoa-Bosompem, Michael; Tetteh, Thelma; Ayertey, Frederick; Antwi, A; Owusu, Kofi Baffour-Awuah; Dadzie, Kofi Kwofie; Djameh, Georgina Isabella; Tetteh-Tsifoanya, Mark; Iwanaga, Shiro; Appiah, Alfred Ampomah; Ohta, Tomoe; Uto, Takuhiro; Shoyama, Yukihiro; Ohta, Nobuhiro; Gwira, Theresa Manful; Ohashi, Mitsuko

doi:10.9734/ejmp/2018/44972

Cited by 6 publications

(2 citation statements)

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“…Additionally, apoptotic properties were attributed to isolates 22 and 24 . Likewise the previous study, these compounds were isolated from M. lucida leaves (Azerigyik et al 2018 ).…”

Section: Iridoids As a Potential Antileishmanial Classmentioning

confidence: 80%

Revisiting nature: a review of iridoids as a potential antileishmanial class

2021

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Leishmaniasis still stands as one of the most prevalent neglected tropical diseases in the least developed and emerging countries. The recommended therapeutic arsenal to treat leishmaniasis is characterized by several shortcomings, and resistance has already been reported. Hence, this dramatic background highlights the pressing need to develop novel, affordable, and safe antileishmanial drugs. Multiple classes of natural compounds have been reported to possess antileishmanial activity. Among these classes, iridoids stand out as a special type of monoterpenoids with diverse biological properties—including their antileishmanial potential. This review aims to discuss the available literature between 1991 and 2020 related to the antileishmanial activity of the iridoid class. Throughout the past decades, various investigations attributed antileishmanial action to assorted iridoid types, including inhibitory potential towards validated drug targets and immunomodulatory activity. The latter deserves special attention due to the ability of some iridoids to improve the host’s immune response against parasites. It opens the possibility of iridoids become adjuncts in leishmaniasis treatments by improving the efficacy of currently employed drugs. Furthermore, the present study intends to provide a convenient visual representation of which iridoids and Leishmania spp. species have been most investigated as a guide for further researches.

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“…Additionally, apoptotic properties were attributed to isolates 22 and 24 . Likewise the previous study, these compounds were isolated from M. lucida leaves (Azerigyik et al 2018 ).…”

Section: Iridoids As a Potential Antileishmanial Classmentioning

confidence: 80%

Revisiting nature: a review of iridoids as a potential antileishmanial class

2021

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“…Blood stream forms of Trypanosoma brucei subsp. brucei strain GUTat 3.1 were cultivated in vitro to the logarithm phase using Hirum's modified Iscove's media (HMI9, Thermo Fisher Scientific) supplemented with 10% fetal bovine serum (Thermo Fisher Scientific) at 5% CO 2 and 37 • C. Leishmania donovani (Laveran and Mesnil) Ross (D10) was cultivated in vitro to the logarithm phase using medium 199 (M199, Thermo Fisher Scientific) with 10% FBS at 5% CO 2 and 37 • C. Mouse macrophages (RAW 264.7 cell lines) were cultivated in vitro to the logarithm phase using Dulbecco's modified eagle media (DMEM, Thermo Fisher Scientific) with 10% fetal bovine serum at 5% CO 2 and 37 • C [15,16].…”

Section: Culture Of Parasites and Mammalian Cell Linesmentioning

confidence: 99%

Digyaindoleacid A: 2-(1-(4-Hydroxyphenyl)-3-oxobut-1-en-2-yloxy)-3-(1H-indol-3-yl)propanoic Acid, a Novel Indole Alkaloid

Kwain

Tetevi

Mensah

et al. 2019

Molbank

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Digyaindoleacid A (1) is one of the novel alkaloids produced by the Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Brong Ahafo Region, Ghana. This compound was isolated on HPLC at tR ≈ 60 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against Trypanosoma brucei subsp. brucei strain GUTat 3.1, 1 produced a half-maximal inhibitory concentration (IC50) 5.21 μM compared to the standard diminazene aceturate (IC50 = 1.86 μM). In the presence of normal mouse macrophages RAW 264.7, 1 displayed a higher selectivity towards T. brucei subsp. brucei (selectivity indices (SI) = 30.2) with low toxicity. This result is interesting given that the drug diminazene aceturate is considerably toxic and 1 is a natural product isolate. The structure of 1 incorporates the backbone of the amino acid tryptophan which is crucial in the metabolism of Trypanosoma brucei subsp. brucei strain GUTat 3.1. It is possible that 1, could interfere with the normal uptake and metabolism of tryptophan in the parasite. However, 1 (IC50 = 135.41 μM) produced weak antileishmanial activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10).

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Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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In vitro Mechanistic Assays of Tetracyclic Iridoid Compounds Isolated from Morinda lucida Benth in Leishmania species

Cited by 6 publications

References 0 publications

Revisiting nature: a review of iridoids as a potential antileishmanial class

Revisiting nature: a review of iridoids as a potential antileishmanial class

Digyaindoleacid A: 2-(1-(4-Hydroxyphenyl)-3-oxobut-1-en-2-yloxy)-3-(1H-indol-3-yl)propanoic Acid, a Novel Indole Alkaloid

Indian Morinda species: A review

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