In Vitro Methods to Simulate Pollution and Photo-Pollution Exposure in Human Skin Epidermis

Misra, Namita; Marrot, Laurent

doi:10.1007/7651_2020_279

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In parallel, keratinocytes exposed to the combination of benzo[a]pyrene and indenopyrene at very low concentrations and exposed to UVA1 have impaired proliferation and clonogenic potential [ 233 ], as well as hampered DNA repair [ 234 ]. In a reconstructed skin model, UVA1 combined with benzo[a]pyrene led to drastic epidermal alterations [ 235 ].…”

Section: Combined Effects Of Uva and Other Environmental Factorsmentioning

confidence: 99%

The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity

Bernerd

Passeron

Castiel

et al. 2022

IJMS

View full text Add to dashboard Cite

Within solar ultraviolet (UV) light, the longest UVA1 wavelengths, with significant and relatively constant levels all year round and large penetration properties, produce effects in all cutaneous layers. Their effects, mediated by numerous endogenous chromophores, primarily involve the generation of reactive oxygen species (ROS). The resulting oxidative stress is the major mode of action of UVA1, responsible for lipid peroxidation, protein carbonylation, DNA lesions and subsequent intracellular signaling cascades. These molecular changes lead to mutations, apoptosis, dermis remodeling, inflammatory reactions and abnormal immune responses. The altered biological functions contribute to clinical consequences such as hyperpigmentation, inflammation, photoimmunosuppression, sun allergies, photoaging and photocancers. Such harmful impacts have also been reported after the use of UVA1 phototherapy or tanning beds. Furthermore, other external aggressors, such as pollutants and visible light (Vis), were shown to induce independent, cumulative and synergistic effects with UVA1 rays. In this review, we synthetize the biological and clinical effects of UVA1 and the complementary effects of UVA1 with pollutants or Vis. The identified deleterious biological impact of UVA1 contributing to clinical consequences, combined with the predominance of UVA1 rays in solar UV radiation, constitute a solid rational for the need for a broad photoprotection, including UVA1 up to 400 nm.

show abstract

Section: Combined Effects Of Uva and Other Environmental Factorsmentioning

confidence: 99%

The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity

Bernerd

Passeron

Castiel

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

A satellite-based, near real-time, street-level resolution air pollutants monitoring system using machine learning for personalised skin health applications

Temple,

May,

Linden

et al. 2024

Air Qual Atmos Health

View full text Add to dashboard Cite

Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis

et al. 2020

View full text Add to dashboard Cite

STUDY QUESTION Are there any associations between environmental pollutants and ovarian reserve, expressed by anti-Mullerian hormone (AMH) serum levels? SUMMARY ANSWER In this first real-world approach to demonstrate the relationship between air pollutants and serum AMH levels, adverse associations were observed for nitrogen dioxide (NO2) but not with particulate matter. WHAT IS KNOWN ALREADY In recent years, air pollution has emerged as a potential disrupter to the homeostasis of physiological hormones, possibly affecting human reproduction. Although the influence of age and smoking on AMH levels is largely accepted, the relationship between AMH and the environment has not currently been established. STUDY DESIGN, SIZE, DURATION A longitudinal, observational, retrospective, real-world study was carried out, including all AMH measurements performed in a single laboratory from January 2007 to October 2017. PARTICIPANTS/MATERIALS, SETTING, METHODS Serum AMH data were connected to patients’ age and residential address, to include air pollution data after geo-localisation. The air pollution considered daily particulate matter (PM) and NO2 values. MAIN RESULTS AND THE ROLE OF CHANCE A total of 1463 AMH measurements were collected (mean 1.94 ng/ml, median 0.90 ng/ml). AMH was inversely related to patients’ age in women older than 25 years (adjusted R-squared 0.120, P < 0.001), but not in those younger than 25 years (adjusted R-squared 0.068, P = 0.055). AMH levels were inversely related to environmental pollutants, such as PM10 (Rho = −0.088, P = 0.001), PM2.5 (Rho = −0.062, P = 0.021) and NO2 (Rho = −0.111, P < 0.001). After subdividing the dataset into quartiles for PM10 and PM2.5, the influence of age on AMH serum levels was found to be a stronger influence than that exerted by PM (P = 0.833 and P = 0.370, respectively). On the contrary, considering NO2 quartiles, higher AMH levels were observed in third quartile compared to fourth quartile, even after adjustment for age (P = 0.028), indicating a stronger influence of NO2 exposure on AMH serum levels. Considering an AMH cut-off of 0.3 ng/ml, a significant higher frequency of women with severe ovarian reserve reduction in the fourth quartile was shown only for NO2 (P = 0.010). LIMITATIONS, REASONS FOR CAUTION Several limitations should be underlined, such as the lack of information about work and life habits of each patient and the retrospective nature of the analysis performed on real-world data. WIDER IMPLICATIONS OF THE FINDINGS Although the genetic component is highly predictive for defining the ovarian reserve at birth, potentially modifiable environmental factors could influence the rate of decline in AMH and ovarian reserve during adulthood. STUDY FUNDINGCOMPETING INTEREST(S) Authors have neither funding nor competing interests to declare. TRIAL REGISTRATION NUMBER N/A.

show abstract

In Vitro Methods to Simulate Pollution and Photo-Pollution Exposure in Human Skin Epidermis

Cited by 3 publications

References 15 publications

The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity

The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity

A satellite-based, near real-time, street-level resolution air pollutants monitoring system using machine learning for personalised skin health applications

Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis

Contact Info

Product

Resources

About